Search Results - "animal models"

Living with brain cancer: From researcher to patient by Stephen Chelko, Daniel Fay

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Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments by Cao P, Zhang H, Meng H, Cheng Y, Xu H, Zang S, Li Z, Cui J, Li Y

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An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract by Naik Suresh R, Panda Vandana S, Lagishetty Chakradhar V, Fernandes Nafisa PC

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P2X7 Receptor Expression in Patients With Serositis Related to Systemic Lupus Erythematosus by Federica Furini, Anna Lisa Giuliani, Mattia Erminio Parlati, Marcello Govoni, Francesco Di Virgilio, Alessandra Bortoluzzi

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Modeling mosquito-borne and sexual transmission of Zika virus in an enzootic host, the African green monkey. by Andrew D Haddow, Unai Perez-Sautu, Michael R Wiley, Lynn J Miller, Adrienne E Kimmel, Lucia M Principe, Suzanne E Wollen-Roberts, Joshua D Shamblin, Stephanie M Valdez, Lisa H Cazares, William D Pratt, Franco D Rossi, Luis Lugo-Roman, Sina Bavari, Gustavo F Palacios, Aysegul Nalca, Farooq Nasar, M Louise M Pitt

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Luobitong Potentiates MTX’s Anti-Rheumatoid Arthritis Activity via Targeting Multiple Inflammatory Pathways by Li Z, Zhang Q, Gao Y, Wan F, Wang Y, Hou B, Cui W, Wang Y, Feng W, Hou Y

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Alteration of EIF2 Signaling, Glycolysis, and Dopamine Secretion in Form-Deprived Myopia in Response to 1% Atropine Treatment: Evidence From Interactive iTRAQ-MS and SWATH-MS Prote... by Ying Zhu, Jing Fang Bian, Da Qian Lu, Chi Ho To, Chi Ho To, Chi Ho To, Carly Siu-Yin Lam, Carly Siu-Yin Lam, Carly Siu-Yin Lam, King Kit Li, Feng Juan Yu, Bo Teng Gong, Qiong Wang, Xiao Wen Ji, Hong Mei Zhang, Hong Nian, Thomas Chuen Lam, Thomas Chuen Lam, Thomas Chuen Lam, Thomas Chuen Lam, Rui Hua Wei

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Safety Study of an Original Mesenchymal Stromal Cell Secretome-Based Medicinal Product for Spermatogenesis Restoration by A. O. Monakova, G. D. Sagaradze, V. Yu. Balabanyan, N. A. Basalova, A. A. Matichina, A. A. Matichin, K. L. Kryshen, V. S. Popov, Zh. A. Akopyan, A. Yu. Efimenko

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Dolphin CONTINUE: a multi-center randomized controlled trial to assess the effect of a nutritional intervention on brain development and long-term outcome in infants born before 30... by E. Janson, P. C. M. P. Koolschijn, L. Schipper, T. D. Boerma, F. N. K. Wijnen, W. P. de Boode, C. H. P. van den Akker, R. G. Licht-van der Stap, D. H. G. M. Nuytemans, W. Onland, S. A. Obermann-Borst, J. Dudink, C. G. M. de Theije, M. J. N. L. Benders, N. E. van der Aa

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A Brief Perspective on Anti-inflammatory Effects of Thymol and Carvacrol by Mohsen Alizadeh, Reza Mohammadrezaei Khorramabadi, Fatemeh Beiranvand, Jabar Soori, Amin Hasanvand *

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A mechanistic study on the inhibition of bacterial growth and inflammation by Nerium oleander extract with comprehensive in vivo safety profile by Yousra Shafiq, Syed Baqir Shyum Naqvi, Ghazala H. Rizwani, Muhammad Arif Asghar, Rabia Bushra, Sana Ghayas, Ahad Abdul Rehman, Muhammad Asif Asghar

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Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity by Martinez Jean, Beaudet Nicolas, Belleville Karine, Ezzoubaa Faouzi, Baudisson Stéphanie, Dansereau Marc-André, Roussy Geneviève, Richelson Elliott, Sarret Philippe

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Identifying and Validating Extracellular Matrix-Related Gene CTSH in Diabetic Foot Ulcer Using Bioinformatics and Machine Learning by Wu PY, Yu YL, Zhao WR, Zhou B

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Thalidomide Analogs in Brazil: Concern About Teratogenesis / Análogos da Talidomida no Brasil: Preocupação com a Teratogênese by Fernanda Sales Luiz Vianna, Maria Teresa Vieira Sanseverino, Lavinia Schuler-Faccini

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KLF13 restrains Dll4‐muscular Notch2 axis to improve the muscle atrophy by Shu Yang, Lijiao Xiong, Guangyan Yang, Jiaqing Xiang, Lixing Li, Lin Kang, Zhen Liang

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Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer by Anna Tesei, Michela Cortesi, Sara Pignatta, Chiara Arienti, Giulio Massimo Dondio, Chiara Bigogno, Alessio Malacrida, Mariarosaria Miloso, Cristina Meregalli, Alessia Chiorazzi, Valentina Carozzi, Guido Cavaletti, Marta Rui, Annamaria Marra, Daniela Rossi, Simona Collina

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Primary skeletal muscle cells from chronic kidney disease patients retain hallmarks of cachexia in vitro by Luke A. Baker, Thomas F. O'Sullivan, Katherine A. Robinson, Matthew P.M. Graham‐Brown, Rupert W. Major, Robert U. Ashford, Alice C. Smith, Andrew Philp, Emma L. Watson

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Antisense RNA Design, Delivery, and Analysis

Table of Contents: “…Introduction and History of the Chemistry of Nucleic Acids Therapeutics -- Antisense RNA Therapeutics: A Brief Overview -- Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion -- Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation -- How to Design U1 snRNA Molecules for Splicing Rescue -- Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles -- Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay -- Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen -- Development and Use of Cellular Systems to Assess and Correct Splicing Defects -- Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells -- In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin -- In Vitro Delivery of PMOs in Myoblasts by Electroporation -- Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts -- Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy -- Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro -- Eye on a Dish Models to Evaluate Splicing Modulation -- Establishment of In Vitro Brain Models for AON Delivery -- Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides -- Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies -- Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment -- In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin -- Delivery of Antisense Oligonucleotides to the Mouse Retina -- Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections -- Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System -- Preclinical Safety Assessment of Therapeutic Oligonucleotides -- Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice -- Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution -- Patent Considerations When Embarking on New Antisense Drug Programs.…”
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Innovative Medicine Basic Research and Development /

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The biology of the first 1000 days

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