Search Results - "blood–brain barrier"

Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice by Manon Duquenne, Eleonora Deligia, Cintia Folgueira, Cyril Bourouh, Emilie Caron, Frank Pfrieger, Markus Schwaninger, Ruben Nogueiras, Jean-Sébastien Annicotte, Monica Imbernon, Vincent Prévot

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A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function by Lara Garcia-Varela, Khaled Attia, John Carlo Sembrano, Olivier Jacquet, Inês F. Antunes, Chantal Kwizera, Ton J. Visser, Rudi A. J. O. Dierckx, Philip H. Elsinga, Gert Luurtsema

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An In Vitro Evaluation of the Potential Neuroprotective Effects of Intranasal Lipid Nanoparticles Containing Astaxanthin Obtained from Different Sources: Comparative Studies by Joana Torres, José Miguel Pereira, Rita Marques-Oliveira, Inês Costa, Eva Gil-Martins, Renata Silva, Fernando Remião, Andreia Filipa Peixoto, José Manuel Sousa Lobo, Ana Catarina Silva

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Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics by Arnaud Dance, Justine Fernandes, Bénédicte Toussaint, Emmanuel Vaillant, Raphaël Boutry, Morgane Baron, Hélène Loiselle, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Mark Ibberson, Michel Marre, Marie Gernay, Marjorie Fadeur, Nicolas Paquot, Martine Vaxillaire, Mathilde Boissel, Souhila Amanzougarene, Mehdi Derhourhi, Amna Khamis, Philippe Froguel, Amélie Bonnefond

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In vitro, in vivo, and in silico approaches for evaluating the preclinical DMPK profiles of ammoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor by Xiuqing Zhu, Xiuqing Zhu, Yuexin Li, Huan Luo, Yunxia Zhang, Zhenqing Zhang, Jinglai Li

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Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug. by Lisa Sanderson, Marcelo da Silva, Gayathri N Sekhar, Rachel C Brown, Hollie Burrell-Saward, Mehmet Fidanboylu, Bo Liu, Lea Ann Dailey, Cécile A Dreiss, Chris Lorenz, Mark Christie, Shanta J Persaud, Vanessa Yardley, Simon L Croft, Margarita Valero, Sarah A Thomas

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Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expre... by Joost Verbeek, Jonas Eriksson, Stina Syvänen, Marc Huisman, Robert C. Schuit, Carla F. M. Molthoff, Rob A. Voskuyl, Elizabeth C. de Lange, Adriaan A. Lammertsma, Albert D. Windhorst

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Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells by Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria, Nhan L. Tran

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Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic... by Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Sofya V. Lushchekina, Tatiana Yu Astakhova, Elena N. Timokhina, Olga G. Serebryakova, Alexander V. Shchepochkin, Alexander V. Shchepochkin, Maxim A. Averkov, Maxim A. Averkov, Irina A. Utepova, Irina A. Utepova, Nadezhda S. Demina, Eugene V. Radchenko, Eugene V. Radchenko, Vladimir A. Palyulin, Vladimir A. Palyulin, Vladimir P. Fisenko, Sergey O. Bachurin, Oleg N. Chupakhin, Oleg N. Chupakhin, Valery N. Charushin, Valery N. Charushin, Rudy J. Richardson, Rudy J. Richardson, Rudy J. Richardson, Rudy J. Richardson

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VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans by Rita Schüler, Nicole Seebeck, Martin A. Osterhoff, Veronica Witte, Agnes Flöel, Andreas Busjahn, Alexander Jais, Jens C. Brüning, Turid Frahnow, Stefan Kabisch, Olga Pivovarova, Silke Hornemann, Michael Kruse, Andreas F.H. Pfeiffer

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Luteolin Enhances Choroid Plexus 5-MTHF Brain Transport to Promote Hippocampal Neurogenesis in LOD Rats by Hui-Zhen Li, Kai-Ge Liu, Ning-Xi Zeng, Xiao-Feng Wu, Wen-Jun Lu, Han-Fang Xu, Can Yan, Li-Li Wu

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Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature by Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI

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Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models by Yan Wang, Yan Wang, Chang Li, Chang Li, Zhongyv Xiong, Niangen Chen, Xuesong Wang, Junyv Xu, Yuemei Wang, Longfeng Liu, Hang Wu, Caihui Huang, Aiqin Huang, Jiajia Tan, Youbin Li, Qifu Li, Qifu Li

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NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders by Ayodeji Olatunde Egunlusi, Jacques Joubert

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Maternal plasma levels of oxytocin during physiological childbirth - a systematic review with implications for uterine contractions and central actions of oxytocin by Kerstin Uvnäs-Moberg, Anette Ekström-Bergström, Marie Berg, Sarah Buckley, Zada Pajalic, Eleni Hadjigeorgiou, Alicja Kotłowska, Luise Lengler, Bogumila Kielbratowska, Fatima Leon-Larios, Claudia Meier Magistretti, Soo Downe, Bengt Lindström, Anna Dencker

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Salvianolic Acid Alleviated Blood–Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway by Wu Q, Yuan X, Li B, Han R, Zhang H, Xiu R

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Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate by Alexander T. H. Wu, Bashir Lawal, Li Wei, Ya-Ting Wen, David T. W. Tzeng, Wen-Cheng Lo

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The efficacy and safety of a nicotine conjugate vaccine (NicVAX^®) or placebo co-administered with varenicline (Champix^®) for smoking cessation: study protocol... by Hoogsteder Philippe HJ, Kotz Daniel, van Spiegel Paul I, Viechtbauer Wolfgang, Brauer Ruth, Kessler Paul D, Kalnik Matthew W, Fahim Raafat EF, van Schayck Onno CP

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Melittin - the main component of bee venom: a promising therapeutic agent for neuroprotection through keap1/Nrf2/HO-1 pathway activation by Cong Duc Nguyen, Jaehee Yoo, Sang Jun Jeong, Hai-Anh Ha, Ji Hye Yang, Gihyun Lee, Jeong Cheol Shin, Jae-Hong Kim

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Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis by Li Y, Li C, Luo T, Yue T, Xiao W, Yang L, Zhang Z, Han F, Long P, Hu Y

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