Search Results - "drug development"

Targeting Lysine Deacetylases (KDACs) in Parasites. by Qi Wang, Bruce A Rosa, Bakela Nare, Kerrie Powell, Sergio Valente, Dante Rotili, Antonello Mai, Garland R Marshall, Makedonka Mitreva

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A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations by Cristiane Franco Codevilla, Tamara dos Santos Castilhos, Ana Maria Bergold

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Identification of lncRNA Signature of Tumor-Infiltrating T Lymphocytes With Potential Implications for Prognosis and Chemotherapy of Head and Neck Squamous Cell Carcinoma by Liping Wang, Gui Yang, Guohong Liu, Yunbao Pan

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Preclinical Drug Pharmacokinetic, Tissue Distribution and Excretion Profiles of the Novel Limonin Derivate HY-071085 as an Anti-Inflammatory and Analgesic Candidate in Rats and Bea... by Liping Dong, Wenjuan Liu, Xiaoyuan Zhao, Feng Yu, Yungen Xu, Mengxiang Su

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The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways by Cao X, Li Y, Shi J, Tang H

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Computational Drug Repurposing for Alzheimer's Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies by Yun Xu, Jiming Kong, Pingzhao Hu

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Evaluation of primary hepatocyte function using 2D or 3D culture method for primary rat hepatocytes by Malgum Lim, Yeongji Kim, Yurianna Shin, Keon Bong Oh, Seongsoo Hwang, Youngim Kim, Tai-Young Hur, Sun A Ock

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The New First-in-Human EMA Guideline: Disruptive or Constructive? Outcomes From the First EUFEMED Discussion Forum by Kerstin Breithaupt-Grögler, Tim Hardman, Tim Hardman, Jan de Hoon, Yves Donazzolo, Sylvie Rottey, Hildegard Sourgens, Steffan Stringer

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Antihypertensive effects of the hydro-ethanol extract of Senecio serratuloides DC in rats by Charlotte Mungho Tata, Constance Rufaro Sewani-Rusike, Opeoluwa Oyehan Oyedeji, Ephraim Tobela Gwebu, Fikile Mahlakata, Benedicta Ngwenchi Nkeh-Chungag

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Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells by Alexander M. Scherbakov, Alexander V. Komkov, Anna S. Komendantova, Margarita A. Yastrebova, Olga E. Andreeva, Valerii Z. Shirinian, Alakananda Hajra, Igor V. Zavarzin, Yulia A. Volkova

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Plasma levels of platelet-enriched microRNAs change during antiplatelet therapy in healthy subjects by Teresa L. Krammer, Marietta Kollars, Paul A. Kyrle, Matthias Hackl, Sabine Eichinger, Ludwig Traby

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Exposure of LS-180 Cells to Drugs of Diverse Physicochemical and Therapeutic Properties Up-regulates P-glycoprotein Expression and Activity by Alaa H Abuznait, Shawn G Patrick, Amal Kaddoumi

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Diisopropylphenyl-imidazole (DII): A new compound that exerts anthelmintic activity through novel molecular mechanisms. by María Gabriela Blanco, María Soledad Vela Gurovic, Gustavo Fabián Silbestri, Andrés Garelli, Sebastián Giunti, Diego Rayes, María José De Rosa

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Ensemble of structure and ligand-based classification models for hERG liability profiling by Serena Vittorio, Filippo Lunghini, Alessandro Pedretti, Giulio Vistoli, Andrea R. Beccari

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Antibody markup language (AbML) - a notation language for antibody-based drug formats and software for creating and rendering AbML (abYdraw) by James Sweet-Jones, Maham Ahmad, Andrew C.R. Martin

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Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model by Joske Millecam, Thomas van Bergen, Stijn Schauvliege, Gunther Antonissen, Ann Martens, Koen Chiers, Ronette Gehring, Elke Gasthuys, Johan Vande Walle, Siska Croubels, Mathias Devreese

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Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells by Yoshihisa Matsushita, Yoshiyuki Furutani, Rumiko Matsuoka, Toru Furukawa

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An Evaluation of Sex-Specific Pharmacokinetics and Bioavailability of Kokusaginine: An In Vitro and In Vivo Investigation by Kaiqi Shang, Chengyu Ge, Yindi Zhang, Jing Xiao, Shao Liu, Yueping Jiang

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A systematic review of the clinical profile of patients with bubonic plague and the outcome measures used in research settings. by Josephine Bourner, Lovarivelo Andriamarohasina, Alex Salam, Nzelle Delphine Kayem, Rindra Randremanana, Piero Olliaro

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MT‐102 prevents tissue wasting and improves survival in a rat model of severe cancer cachexia by Mareike S. Pötsch, Junichi Ishida, Sandra Palus, Anika Tschirner, Stephan vonHaehling, Wolfram Doehner, Stefan D. Anker, Jochen Springer

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