Search Results - "molecule"

Cytotoxicity evaluation of haloperidol, clozapine and a new molecule with antipsychotic potential, PT-31, in NIH-3T3 cells by Juliana Machado Kayser, Gabriela Zimmermann Prado Rodrigues, Carlos Henrique Thomazi, Alana Witt Hansen, Marina Griebeler Moreira, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Ana Luiza Ziulkoski, Andresa Heemann Betti

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Development of Machine Learning Models for Accurately Predicting and Ranking the Activity of Lead Molecules to Inhibit PRC2 Dependent Cancer by Danishuddin, Vikas Kumar, Shraddha Parate, Ashutosh Bahuguna, Gihwan Lee, Myeong Ok Kim, Keun Woo Lee

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Importance of Incorporating Protein Flexibility in Molecule Modeling: A Theoretical Study on Type I1/2 NIK Inhibitors by Chao Shen, Hui Liu, Xuwen Wang, Tailong Lei, Ercheng Wang, Lei Xu, Huidong Yu, Dan Li, Xiaojun Yao

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Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules by Praveenkumar Devarbhavi, Lata Telang, Basavaraj Vastrad, Anandkumar Tengli, Chanabasayya Vastrad, Iranna Kotturshetti

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Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis by Thomas J. Wubben, Sraboni Chaudhury, Brennan T. Watch, Jeanne A. Stuckey, Eric Weh, Roshini Fernando, Moloy Goswami, Mercy Pawar, Jason C. Rech, Cagri G. Besirli

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Differential Immunoexpression of Inhibitory Immune Checkpoint Molecules and Clinicopathological Correlates in Keratoacanthoma, Primary Cutaneous Squamous Cell Carcinoma and Metastases by Anke S. Lonsdorf, Dominic Edelmann, Thomas Albrecht, Alexander Brobeil, Jannik Labrenz, Moritz Johanning, Richard F. Schlenk, Benjamin Goeppert, Alexander H. Enk, Ferdinand Toberer

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Umbelliferone and Its Synthetic Derivatives as Suitable Molecules for the Development of Agents with Biological Activities: A Review of Their Pharmacological and Therapeutic Potential by Anita Kornicka, Łukasz Balewski, Monika Lahutta, Jakub Kokoszka

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Phase I pharmacokinetic study of an oral, small-molecule MEK inhibitor tunlametinib in patients with advanced NRAS mutant melanoma by Qian Zhao, Teng Wang, Huanhuan Wang, Cheng Cui, Wen Zhong, Diyi Fu, Wanlin Xi, Lu Si, Jun Guo, Ying Cheng, Hongqi Tian, Pei Hu

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Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer by Seyed Esmaeil Ahmadi, Ashkan Shabannezhad, Amir Kahrizi, Armin Akbar, Seyed Mehrab Safdari, Taraneh Hoseinnezhad, Mohammad Zahedi, Soroush Sadeghi, Mahsa Golizadeh Mojarrad, Majid Safa

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Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail by Lorena V. Cortés-Medina, Herminia Pasantes-Morales, Alejandro Aguilera-Castrejon, Arturo Picones, Cesar O. Lara-Figueroa, Enoch Luis, Juan Jose Montesinos, Victor A. Cortés-Morales, M. P. De la Rosa Ruiz, Erika Hernández-Estévez, Laura C. Bonifaz, Marco Antonio Alvarez-Perez, Gerardo Ramos-Mandujano

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Transport Mechanisms at the Blood-Brain Barrier and in Cellular Compartments of the Neurovascular Unit: Focus on CNS Delivery of Small Molecule Drugs by Patrick T. Ronaldson, Thomas P. Davis

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Aliskiren: Just a New Drug for Few Selected Patients or an Innovative Molecule Predestinated to Replace Arbs and Ace-Inhibitors? by Elena Raccuglia, Giovanni Fazio, Salvatore Novo

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Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis by Rongrong Zhang, Hongyin Zhang, Shuai Shao, Yingxin Shen, Fengqin Xiao, Jiaming Sun, Songlan Piao, Daqing Zhao, Guangzhe Li, Mingming Yan

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Exploring Antiparasitic Molecule Sources from Timber by-Product Industries-Leishmanicidal and Trypanocidal Compounds from Clathrotropis brunnea Amshoff by Fernando Torres, Sara M. Robledo, Wiston Quiñones, Gustavo Escobar, Rosendo Archbold, Edwin Correa, Juan Fernando Gil, Natalia Arbeláez, Javier Murillo, Fernando Echeverri

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Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry by Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong-Feng Xu

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A New Class of PSMA-617-Based Hybrid Molecules for Preoperative Imaging and Intraoperative Fluorescence Navigation of Prostate Cancer by Ann-Christin Eder, Jessica Matthias, Martin Schäfer, Jana Schmidt, Nils Steinacker, Ulrike Bauder-Wüst, Lisa-Charlotte Domogalla, Mareike Roscher, Uwe Haberkorn, Matthias Eder, Klaus Kopka

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Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery by Tarik Zahr, Vijay K. Boda, Jian Ge, Lexiang Yu, Zhongzhi Wu, Jianwen Que, Wei Li, Li Qiang

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A Novel Catecholopyrimidine Based Small Molecule PDE4B Inhibitor Suppresses Inflammatory Cytokines in Atopic Mice by Baskaran Purushothaman, Parthasarathy Arumugam, Joon Myong Song

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CO-Releasing Molecule (CORM)-3 Ameliorates Spinal Cord-Blood Barrier Disruption Following Injury to the Spinal Cord by Gang Zheng, Gang Zheng, Fanghong Zheng, Fanghong Zheng, Fanghong Zheng, Zucheng Luo, Zucheng Luo, Haiwei Ma, Haiwei Ma, Dongdong Zheng, Guangheng Xiang, Guangheng Xiang, Cong Xu, Cong Xu, Yifei Zhou, Yifei Zhou, Yifei Zhou, Yaosen Wu, Yaosen Wu, Yaosen Wu, Naifeng Tian, Naifeng Tian, Naifeng Tian, Yan Wu, Tan Zhang, Wenfei Ni, Wenfei Ni, Sheng Wang, Sheng Wang, Sheng Wang, Huazi Xu, Huazi Xu, Huazi Xu, Xiaolei Zhang, Xiaolei Zhang, Xiaolei Zhang, Xiaolei Zhang

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Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability by Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Karen A. Kirby, Haijuan Du, Huanchun Zhang, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, Zhengqiang Wang

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