Zoekresultaten - "oligonucleotide"

Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping door Alex Zhu, Shuntaro Chiba, Yuki Shimizu, Katsuhiko Kunitake, Yasushi Okuno, Yoshitsugu Aoki, Toshifumi Yokota

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A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells door Daniela Castanotto, Xiaowei Zhang, Jacqueline Rüger, Jessica Alluin, Ritin Sharma, Patrick Pirrotte, Lars Joenson, Silvia Ioannou, Michael S. Nelson, Jonas Vikeså, Bo Rode Hansen, Troels Koch, Mads Aaboe Jensen, John J. Rossi, Cy A. Stein

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Inhibition of post-trabeculectomy fibrosis via topically instilled antisense oligonucleotide complexes co-loaded with fluorouracil door Kuan Jiang, Junyi Chen, Lingyu Tai, Chang Liu, Xishan Chen, Gang Wei, Weiyue Lu, Weisan Pan

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Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor door Dwi U Kemaladewi, Svitlana Pasteuning, Joke W van der Meulen, Sandra H van Heiningen, Gert-Jan van Ommen, Peter ten Dijke, Annemieke Aartsma-Rus, Peter AC 't Hoen, Willem M Hoogaars

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Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection door Amy E. Byrnes, Sara L. Dominguez, Chun-Wan Yen, Benjamin I. Laufer, Oded Foreman, Mike Reichelt, Han Lin, Meredith Sagolla, Kathy Hötzel, Hai Ngu, Christoffer Soendergaard, Alberto Estevez, Hsiu-Chao Lin, Alexandre Goyon, Juan Bian, Jessica Lin, Flora I. Hinz, Brad A. Friedman, Amy Easton, Casper C. Hoogenraad

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Sequence diversity within the HA-1 gene as detected by melting temperature assay without oligonucleotide probes door Mattiuz Pier, Malentacchi Cecilia, Giorgi Massimo, Graziano Claudio, Porfirio Berardino

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A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides door Andreas Dieckmann, Peter H. Hagedorn, Yvonne Burki, Christine Brügmann, Marco Berrera, Martin Ebeling, Thomas Singer, Franz Schuler

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Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides door Suzan M Hammond, Graham McClorey, Joel Z Nordin, Caroline Godfrey, Sofia Stenler, Kim A Lennox, CI Edvard Smith, Ashley M Jacobi, Miguel A Varela, Yi Lee, Mark A Behlke, Matthew J A Wood, Samir E L Andaloussi

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Quantitative Analysis of Survivin Protein Expression and Its Therapeutic Depletion by an Antisense Oligonucleotide in Human Lung Tumors door Anna L Olsen, Joanne M Davies, Louise Medley, David Breen, Denis C Talbot, Peter J McHugh

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Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking door Daisuke Ono, Ken Asada, Daishi Yui, Fumika Sakaue, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota

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Scavenger Receptor Class A1 Mediates Uptake of Morpholino Antisense Oligonucleotide into Dystrophic Skeletal Muscle door Shouta Miyatake, Yoshitaka Mizobe, Maria K. Tsoumpra, Kenji Rowel Q. Lim, Yuko Hara, Fazel Shabanpoor, Toshifumi Yokota, Shin'ichi Takeda, Yoshitsugu Aoki

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Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides door Tsuyoshi Yamamoto, Yahiro Mukai, Fumito Wada, Chisato Terada, Yukina Kayaba, Kaho Oh, Asako Yamayoshi, Satoshi Obika, Mariko Harada-Shiba

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Fructose Promotes Uptake and Activity of Oligonucleotides with Different Chemistries in a Context-Dependent Manner in mdx Mice door Limin Cao, Gang Han, Caorui Lin, Ben Gu, Xianjun Gao, Hong M. Moulton, Yiqi Seow, HaiFang Yin

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Cathepsin B-activatable cyclic antisense oligonucleotides for cell-specific target gene knockdown in vitro and in vivo door Zhongyu Wang, Xinli Fan, Guanqun Mu, Xiaoran Zhao, Qian Wang, Jing Wang, Xinjing Tang

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A Semi‐Mechanistic Population Pharmacokinetic Model of Nusinersen: An Antisense Oligonucleotide for the Treatment of Spinal Muscular Atrophy door Konstantinos Biliouris, Puneet Gaitonde, Wei Yin, Daniel A. Norris, Yanfeng Wang, Scott Henry, Robert Fey, Ivan Nestorov, Stephan Schmidt, Mark Rogge, Lawrence J. Lesko, Mirjam N. Trame

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Modulating the expression of tumor suppressor genes using activating oligonucleotide technologies as a therapeutic approach in cancer door Georgina L. Gregory, Ian M. Copple

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Antisense Oligonucleotide Inhibition of MicroRNA-494 Halts Atherosclerotic Plaque Progression and Promotes Plaque Stabilization door Eva van Ingen, Amanda C. Foks, Mara J. Kröner, Johan Kuiper, Paul H.A. Quax, Ilze Bot, Anne Yaël Nossent

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Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 door Petar S. Lenert

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Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice door Limin Cao, Gang Han, Caorui Lin, Ben Gu, Xianjun Gao, Hong M Moulton, Yiqi Seow, HaiFang Yin

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Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids door Yu Mikame, Asako Yamayoshi

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