Search Results - "pharmacodynamics"

A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma by Sharon M. Rymut, Lindsay M. Henderson, Victor Poon, Tracy L. Staton, Fang Cai, Siddharth Sukumaran, Horace Rhee, Ryan Owen, Saroja Ramanujan, Kenta Yoshida

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Review of Questions Concerning Clinical Drug Interactions in ADHD Treatment From Physicians in Norway by Jan Schjøtt, Jan Schjøtt, Jan Schjøtt, Kristine Heitmann, Kristine Heitmann, Tina Bakkebø, Tina Bakkebø, Jan Anker Jahnsen, Jan Anker Jahnsen, Jan Anker Jahnsen

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PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients by Stefan Willmann, Eleonora Marostica, Nelleke Snelder, Alexander Solms, Markus Jensen, Maximilian Lobmeyer, Anthonie W. A. Lensing, Claudette Bethune, Erin Morgan, Rosie Z. Yu, Yanfeng Wang, Shiangtung W. Jung, Richard Geary, Sanjay Bhanot

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Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children by Blessed W. Aruldhas, Sara K. Quinney, Brian R. Overholser, Michael A. Heathman, Andrea R. Masters, Reynold C. Ly, Hongyu Gao, Senthil Packiasabapathy, Senthilkumar Sadhasivam

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Pharmacological characterization of a novel, potent, selective, and orally active fatty acid amide hydrolase inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroma... by Toshiya Endo, Takashi Takeuchi, Shunsuke Maehara

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A population PK-PD model of YH4808, a novel P‐CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808 by Tae Kyu Chung, Hyun A. Lee, Kyeong‐Ryoon Lee, Seong Bok Jang, Kyung‐Sang Yu, Howard Lee

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Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors by Mirza MU, Ghori NUH, Ikram N, Adil AR, Manzoor S

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In silico trial for the assessment of givinostat dose adjustment rules based on the management of key hematological parameters in polycythemia vera patients by Elena M. Tosca, Alessandro De Carlo, Roberta Bartolucci, Francesco Fiorentini, Silvia Di Tollo, Maurizio Caserini, Maurizio Rocchetti, Paolo Bettica, Paolo Magni

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Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques by Jae Geun Song, Kshitis Chandra Baral, Gyu-Lin Kim, Ji-Won Park, Soo-Hwa Seo, Da-Hyun Kim, Dong Hoon Jung, Nonye Linda Ifekpolugo, Hyo-Kyung Han

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Metabolomics and 16S rRNA Gene Sequencing Analyses of Changes in the Intestinal Flora and Biomarkers Induced by Gastrodia-Uncaria Treatment in a Rat Model of Chronic Migraine by Zhiqi Wen, Mingzhen He, Chunyan Peng, Yifei Rao, Junmao Li, Zhifeng Li, Lijun Du, Lijun Du, Yan Li, Maofu Zhou, Ouyang Hui, Yulin Feng, Yulin Feng, Shilin Yang

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In vivo components analysis of Shenhua tablets active in IgA nephropathy by Huiqiang Liu, Ping Li, Fengting Yin, Hui Sun, Ying Zheng, Chang Liu, Xiangmei Chen, Xiaotong Yan, Xijun Wang

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In vitro Activity of Cefiderocol and Comparators against Carbapenem-Resistant Gram-Negative Pathogens from France and Belgium by Saoussen Oueslati, Pierre Bogaerts, Laurent Dortet, Sandrine Bernabeu, Hend Ben Lakhal, Christopher Longshaw, Youri Glupczynski, Thierry Naas

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PK/PD modeling analysis for dosing regimen selection of isatuximab as single agent and in combination therapy in patients with multiple myeloma by Kimiko Koiwai, Raouf El‐Cheikh, Hoai‐Thu Thai, Claire Brillac, Jean‐Baptiste Fau, Christine Veyrat‐Follet, Marie‐Laure Risse, Helgi van deVelde, Dorothée Semiond, Laurent Nguyen

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Best practices for documentation of psychotropic drug-drug interactions in an adult psychiatric clinic by Kathryn Collins, PharmD, MSPH, Julie A. Dopheide, PharmD, BCPP, FASHP, Mengxi Wang, MPH, Talene Keshishian, MD

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LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial by Christian Loesche, Damien Picard, Benjamin Van Hoorick, Imelda Schuhmann, Petra Jäger, Kai Klein, Carole Schuhler, Gebhard Thoma, Christian Markert, Birk Poller, Natasa Zamurovic, H. Markus Weiss, Heike Otto, Martin Fink, Till A. Röhn

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The N‐Acetylgalactosamine‐conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low‐density lipopro... by Dario Lehoux, David Kallend, Peter L. J. Wijngaard, Alan P. Brown, Brad Zerler

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Proof‐of‐concept for incorporating mechanistic insights from multi‐omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae by Patrick O. Hanafin, Nusaibah Abdul Rahim, Rajnikant Sharma, Colin G. Cess, Stacey D. Finley, Phillip J. Bergen, Tony Velkov, Jian Li, Gauri G. Rao

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Nanostructured lipid carrier system for topical delivery of terbinafine hydrochloride by Bharti Gaba, Mohammad Fazil, Saba Khan, Asgar Ali, Sanjula Baboota, Javed Ali

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Integrated Metabolomics and Network Pharmacology Revealed Hong-Hua-Xiao-Yao Tablet's Effect of Mediating Hormone Synthesis in the Treatment of Mammary Gland Hyperplasia by Ziqing Gao, Rui Mi, Zhaoxi Cheng, Xiaofeng Li, Huawu Zeng, Gaosong Wu, Jing Zhao, Weidong Zhang, Weidong Zhang, Ji Ye

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A Network Pharmacology Analysis of Cang Fu Dao Tan Formula for the Treatment of Obese Polycystic Ovary Syndrome by C.A.I. Meng-Cheng, J.I.N. Yong-Sheng, Y.U. Chao-Qin, Cheng Wen

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