Search Results - "pharmacodynamics"

Puerarin-loaded PEG-PE micelles with enhanced anti-apoptotic effect and better pharmacokinetic profile by Wenqun Li, Junyong Wu, Jiang Zhang, Jingjing Wang, Daxiong Xiang, Shilin Luo, Jianhe Li, Xinyi Liu

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Advancing Precision Medicine: A Review of Innovative In Silico Approaches for Drug Development, Clinical Pharmacology and Personalized Healthcare by Lara Marques, Bárbara Costa, Mariana Pereira, Abigail Silva, Joana Santos, Leonor Saldanha, Isabel Silva, Paulo Magalhães, Stephan Schmidt, Nuno Vale

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Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models by Kalyan Dulla, Monica Aguila, Amelia Lane, Katarina Jovanovic, David A. Parfitt, Iris Schulkens, Hee Lam Chan, Iris Schmidt, Wouter Beumer, Lars Vorthoren, Rob W.J. Collin, Alejandro Garanto, Lonneke Duijkers, Anna Brugulat-Panes, Ma'ayan Semo, Anthony A. Vugler, Patricia Biasutto, Peter Adamson, Michael E. Cheetham

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Safety, tolerability, and pharmacokinetics of single‐ and multiple‐ascending doses of olamkicept: Results from randomized, placebo‐controlled, first‐in‐human phase I trials... by Frank‐Dietrich Wagner, Stefan Schreiber, Yu Bagger, Katharina Bruzelius, Ali Falahati, Ola Sternebring, Arjun Ravi, Philippe Pinton

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PK/PD modeling links accelerated resolution of COVID‐19‐related clinical symptoms to SARS‐CoV‐2 viral load reduction in patients following treatment with Bamlanivimab alone or Baml... by C. Steven Ernest II, Jenny Y. Chien, Dipak R. Patel, Emmanuel Chigutsa

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Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet by Mahmoud Teaima, Sandra Hababeh, Mai Khanfar, Fares Alanazi, Doaa Alshora, Mohammed El-Nabarawi

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A Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues by Christian Lohasz, Jacqueline Loretan, Dario Sterker, Ekkehard Görlach, Kasper Renggli, Paul Argast, Olivier Frey, Marion Wiesmann, Markus Wartmann, Martin Rausch, Andreas Hierlemann

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Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling by Victoria Jackson-Patel, Victoria Jackson-Patel, Emily Liu, Matthew R. Bull, Matthew R. Bull, Amir Ashoorzadeh, Amir Ashoorzadeh, Gib Bogle, Gib Bogle, Anna Wolfram, Kevin O. Hicks, Kevin O. Hicks, Jeff B. Smaill, Jeff B. Smaill, Adam V. Patterson, Adam V. Patterson

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Treatment-Resistant Schizophrenia: Genetic and Neuroimaging Correlates by Antonio Vita, Antonio Vita, Alessandra Minelli, Stefano Barlati, Stefano Barlati, Giacomo Deste, Edoardo Giacopuzzi, Paolo Valsecchi, Cesare Turrina, Cesare Turrina, Massimo Gennarelli, Massimo Gennarelli

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Prolonged Infusion of β-Lactams Decreases Mortality in Patients with Septic Shock: A Retrospective before-and-after Study by Daniel Christoph Richter, Maximilian Dietrich, Lazar Detelinov Lalev, Felix C. F. Schmitt, Mascha Onida Fiedler, Thomas Bruckner, Dominic Stoerzinger, Ute Chiriac, Sabrina Klein, Thilo Hackert, Thorsten Brenner, Alexander Brinkmann, Markus A. Weigand

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Spectrum-Effect Relationship Between Antioxidant and Anti-inflammatory Effects of Banxia Baizhu Tianma Decoction: An Identification Method of Active Substances With Endothelial Cel... by Nan Xu, Mingchen Li, Ping Wang, Shuling Wang, Haiyan Shi

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The Therapeutic Potential of Novel Carnosine Formulations: Perspectives for Drug Development by Angela Bonaccorso, Anna Privitera, Margherita Grasso, Sonya Salamone, Claudia Carbone, Rosario Pignatello, Teresa Musumeci, Filippo Caraci, Giuseppe Caruso

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Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist by Yan Xu, Xin Miao, Paulien Ravenstijn, Anja Hijzen, Mark E. Schmidt, Partha Nandy, Honghui Zhou

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In Silico Pharmacy: From Computations to Clinics by Mehdi Soleimani, Mahmoud Mirzaei

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Relevance of the pyroptosis-related inflammasome drug targets in the Chuanxiong to improve diabetic nephropathy by ChangYan Li, JingYuan Ma, Niroj Mali, Le Zhang, Tao Wei, LuYao Shi, Fang Liu, Fan WenXing, Jing Yang

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A population pharmacokinetics analysis assessing the exposure of raltegravir once‐daily 1200 mg in pregnant women living with HIV by Vera E. Bukkems, Teun M. Post, Angela P. Colbers, David M. Burger, Elin M. Svensson

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Asia‐inclusive drug development leveraging principles of ICH E5 and E17 guidelines: Case studies illustrating quantitative clinical pharmacology as a foundational enabler by Hong Lu, Lena Klopp‐Schulze, Jatinder Kaur Mukker, Dandan Li, Yoshihiro Kuroki, Jayaprakasam Bolleddula, Nadia Terranova, Kosalaram Goteti, Wei Gao, Rainer Strotmann, Jennifer Dong, Karthik Venkatakrishnan

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Cardioprotection by Systemic Dosing of Thymosin Beta Four Following Ischemic Myocardial Injury by Gordon Teg Pipes

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The pharmacokinetic, safety, and tolerability profiles of eslicarbazepine acetate are comparable between Korean and White subjects by Sejung Hwang, Soyoung Lee, Eunwoo Kim, Inyoung Hwang, Joo‐Youn Cho, Jae‐Yong Chung, In‐Jin Jang, Jaeseong Oh

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An open‐label, nonrandomized, phase Ib feasibility study of cusatuzumab in patients with nasopharyngeal carcinoma by Astrid De Meulenaere, Tijl Vermassen, David Creytens, Stijn De Keukeleire, Tim Delahaye, Philippe Deron, Fréderic Duprez, Samson Fung, Patrick Pauwels, Liesbeth Ferdinande, Sylvie Rottey

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