Search Results - "pharmacodynamics"

Pharmacodynamic evaluation of the XOR inhibitor WN1703 in a model of chronic hyperuricemia in rats induced by yeast extract combined with potassium oxonate by Yuanyuan Li, Xinying Zhu, Fuyao Liu, Wen Peng, Lei Zhang, Jing Li

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The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses by Yuanxun Yang, Lei Yu, Zejuan Sheng, Hui Lin, Zuyi Weng, Wei Song, Bei Cao, Yu Zhao, Yingsheng Gao, Shumao Ni, Huimin Wang, Tingting Ma, Lei Huang, Caixia Sun, Juan Li

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A pharmacodynamic analysis of resistance trends in pathogens from patients with infection in intensive care units in the United States between 1993 and 2004 by Quinn John P, Lockhart Shawn R, Nicolau David P, Eagye Kathryn J, Doern Gary V, Gallagher Gale, Abramson Murray A

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Sustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic evaluation in rabbits by Nagwa Hussein Fouda, Randa Tag Abdelrehim, Doaa Abdelmagid Hegazy, Basant Ahmed Habib

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Population-pharmacokinetic/pharmacodynamic model of atractylodes lancea (Thunb.)... by Teerachat Saeheng, Juntra Karbwang, Kesara Na-Bangchang

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Association between Augmented Renal Clearance and Inadequate Vancomycin Pharmacokinetic/Pharmacodynamic Targets in Chinese Adult Patients: A Prospective Observational Study by Jinjin Zhao, Yaxin Fan, Minjie Yang, Xiaoyu Liang, Jufang Wu, Yuancheng Chen, Beining Guo, Huifang Zhang, Ruilan Wang, Fengying Zhang, Jingqing Hang, Huayin Li, Jing Zhang

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First-In-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, a Small-Molecule Factor XIa Inhibitor in Healthy Subjects by Rui Chen, Xiaoduo Guan, Pei Hu, Yanli Dong, Yi Zhu, Tengfei Zhang, Jianjun Zou, Shuyang Zhang

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Schlesinger Nailed It! Assessing a Key Primary Pharmacodynamic Property of Phages for Phage Therapy: Virion Encounter Rates with Motionless Bacterial Targets by Stephen T. Abedon

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First‐in‐human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC‐2394, in healthy volunteers by Fei Tang, Rebecca Kunder, Tom Chu, Avis Hains, Allen Nguyen, Jacqueline M. McBride, Yu Zhong, Sara Santagostino, Maria Wilson, Abigail Trenchak, Liuxi Chen, Justin Ly, Anita Moein, Nicholas Lewin‐Koh, Vibha Raghavan, Uyi Osaghae, Chris Wynne, Ryan Owen, David Place

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A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults by Jihyun Jung, Ki Young Huh, Xuanyou Jin, Ahnul Ha, Ki Ho Park, Jun Sang Park, Eunjung Kim, Jaehwi Lee, In‐Jin Jang, Howard Lee

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Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study by Titia Q. Ruijs, Ingrid W. Koopmans, Marieke L. deKam, Martijn R. Tannemaat, Geert Jan Groeneveld, Jules A. A. C. Heuberger

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A population pharmacodynamic Markov mixed‐effects model for determining remimazolam‐induced sedation when co‐administered with fentanyl in procedural sedation by Jie Zhou, Laura Curd, Lauren R. L. Lohmer, Natalie Delpratt, Joachim Ossig, Frank Schippers, Thomas Stoehr, Virginia D. Schmith

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Dalbavancin, Vancomycin and Daptomycin Alone and in Combination with Cefazolin against Resistant Phenotypes of <i>Staphylococcus aureus</i> in a Pharmacokinetic/Pharmacodynamic Model by Jacinda C. Abdul-Mutakabbir, Razieh Kebriaei, Kyle C. Stamper, Zain Sheikh, Philip T. Maassen, Katherine L. Lev, Michael J. Rybak

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Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development by Kayla Ann Andrews, Joel S. Owen, James McCarthy, David Wesche, Nathalie Gobeau, Thaddeus H. Grasela, Jörg J. Möhrle

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Subconjunctival Delivery of Sorafenib-Tosylate-Loaded Cubosomes for Facilitated Diabetic Retinopathy Treatment: Formulation Development, Evaluation, Pharmacokinetic and Pharmacodynamic (PKPD) Studies by Sharadha Madhusudhan, Naresh Vishal Gupta, Mohamed Rahamathulla, Saravana Babu Chidambaram, Riyaz Ali M. Osmani, Mohammed Ghazwani, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Mohammed Y. Sarhan, Ahmed Hediyal Tousif

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A Fixed-Dose Combination Of Gemigliptin And Rosuvastatin Exhibits Similar Pharmacokinetics, Pharmacodynamics, And Safety Compared To That Of A Loose Combination In Healthy Subjects by Kim E, Park KR, Jang IJ, Yu KS, Lee S

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Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study by Yun Kuang, Sai-Ying Wang, Meng-Na Wang, Guo-Ping Yang, Guo-Ping Yang, Guo-Ping Yang, Can Guo, Shuang Yang, Xing-Fei Zhang, Xiao-Yan Yang, Qi Pei, Chan Zou, Chan Zou, Yan-Hong He, Ying-Yong Zhou, Kai-Ming Duan, Jie Huang, Jie Huang

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Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model by Susanne Jacobsson, Daniel Golparian, Joakim Oxelbark, Emilie Alirol, Francois Franceschi, Tomas N. Gustafsson, David Brown, Arnold Louie, George Drusano, Magnus Unemo

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Proniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study by Alaa Emad Eldeeb, Salwa Salah, Mahmoud Ghorab

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Mathematical pharmacodynamic modeling for antimicrobial assessment of ceftazidime/colistin versus gentamicin/meropenem combinations against carbapenem-resistant Pseudomonas aeruginosa biofilm by Mona Shaban E. M. Badawy, Walid F. Elkhatib, Rania I. Shebl

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