Search Results - "pharmacodynamics"

How to Achieve Sufficient Endogenous Insulin Suppression in Euglycemic Clamps Assessing the Pharmacokinetics and Pharmacodynamics of Long-Acting Insulin Preparations Employing Healthy Volunteers by Hui Liu, Ting Li, Hongling Yu, Jiaqi Li, Huiwen Tan, Yerong Yu

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First‐in‐human trial assessing the pharmacokinetic‐pharmacodynamic profile of a novel recombinant human chorionic gonadotropin in healthy women and men of reproductive age by Lars‐Erik Broksø Kyhl, Christiane Hesse, Per Larsson, Katharina Bruzelius, Bernadette Mannaerts

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Remibrutinib (LOU064): A selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial by Martin Kaul, Peter End, Maciej Cabanski, Carole Schuhler, Annamaria Jakab, Magdalena Kistowska, Arvind Kinhikar, Alessio Maiolica, Angela Sinn, Rainard Fuhr, Bruno Cenni

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Changing the Drug Delivery System: Does It Add to Non-Compliance Ramifications Control? A Simulation Study on the Pharmacokinetics and Pharmacodynamics of Atypical Antipsychotic Drug by Mohammed H. Elkomy

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Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations by Hyeon-Cheol Jeong, Min-Gul Kim, Zhuodu Wei, Kyeong-Ryoon Lee, Jaehyeok Lee, Im-Sook Song, Kwang-Hee Shin

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Population pharmacokinetic‐pharmacodynamic modeling of clopidogrel for dose regimen optimization based on CYP2C19 phenotypes: A proof of concept study by Yun Seob Jung, Byung Hak Jin, Min Soo Park, Choon Ok Kim, Dongwoo Chae

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Pharmacokinetic and Pharmacodynamic Effects of Oral CXA‐10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects by Rachel M. Garner, Diane R. Mould, Carla Chieffo, Diane K. Jorkasky

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Pharmacokinetic/pharmacodynamic modeling of drug interactions at the P2Y12 receptor between selatogrel and oral P2Y12 antagonists by Andrea Henrich, Christian Hove Claussen, Jasper Dingemanse, Andreas Krause

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Pharmacokinetics and pharmacodynamics of the factor XIa‐inhibiting antibody osocimab in healthy male East Asian volunteers: Results from two phase 1 studies by Zhili Dong, Kensei Hashizume, Frauke Friedrichs, Pei Liu, Toshiaki Tanaka, Yuqin Liao

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Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of <i>Mycobacterium tuberculosis</i> Infection by Laura Sibley, Andrew D. White, Charlotte Sarfas, Jennie Gullick, Fergus Gleeson, Faye Lanni, Simon Clark, Emma Rayner, Santiago Ferrer-Bazaga, Fatima Ortega-Muro, Laura Alameda, Joaquin Rullas, Veronica Sousa, Marisa Martinez, Inigo Angulo-Barturen, Adolfo Garcia, Juan José Vaquero, Henry E. Pertinez, Geraint Davies, Mike Dennis, Ann Williams, Sally Sharpe

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Kinetic‐Pharmacodynamic Model of Platelet Time Course in Patients With Moderate‐to‐Severe Atopic Dermatitis Treated With Oral Janus Kinase 1 Inhibitor Abrocitinib by Elena Soto, Christopher Banfield, Pankaj Gupta, Mark C. Peterson

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study by Xu HR, Sheng L, Chen WL, Yuan F, Yang MJ, Li H, Li XN, Choi J, Zhao GY, Hu TX, Li YG, Zhang Y, Chen L

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Tissue Levels of Flurbiprofen in the Rat Plantar Heel after Short-Duration Topical Iontophoresis Are Sufficient to Induce Pharmacodynamic Responses to Local Pain Stimuli by Yilu Cai, Ye Zhou, Peiyan Zhang, Yogeshvar N. Kalia, Tais Gratieri, Yong Chen

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Effects of Growth Medium and Inoculum Size on Pharmacodynamics Activity of Marbofloxacin against <i>Staphylococcus aureus</i> Isolated from Caprine Clinical Mastitis by Augusto Matías Lorenzutti, Manuel Ignacio San Andrés-Larrea, Emilio Fernández-Varón, María del Pilar Zarazaga, Ana María Molina-López, Juan Manuel Serrano-Rodríguez

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Model-Informed Drug Development of New Cefoperazone Sodium and Sulbactam Sodium Combination (3:1): Pharmacokinetic/Pharmacodynamic Analysis and Antibacterial Efficacy Against Enterobacteriaceae by Xi-Wei Ji, Xiao Zhu, Yun Li, Feng Xue, Isabelle Hui San Kuan, Isabelle Hui San Kuan, Qing-Feng He, Xiang-Rui Meng, Xiao-Qiang Xiang, Yi-Min Cui, Bo Zheng

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Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon&reg; and Eprex&reg; following a single subcutaneous administration in healthy male volunteers by Yoon S, Rhee SJ, Heo SJ, Oh TY, Yoon SH, Cho JY, Lee S, Yu KS

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A Phase 1, Randomized, Double-Blind, Single-Dose, Placebo-Controlled Safety, Tolerability, And Pharmacokinetic/Pharmacodynamic Study Of Evolocumab In Healthy Chinese Subjects by Liu C, Lu H, Yuan F, Chen WL, Xu HR, Li H, Hsu CP, Egbuna O, Wu J, Dias C, Abosaleem B, Rana J, Monsalvo ML, Li XN, Yu Z

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Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC by Rachel D. Hutchison, Benjamin M. Ford, Lirit N. Franks, Catheryn D. Wilson, Azure L. Yarbrough, Ryoichi Fujiwara, Mark K. Su, Denise Fernandez, Laura P. James, Jeffery H. Moran, Amy L. Patton, William E. Fantegrossi, Anna Radominska-Pandya, Paul L. Prather

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Inclusion of a Phytomedicinal Flavonoid in Biocompatible Surface-Modified Chylomicron Mimic Nanovesicles with Improved Oral Bioavailability and Virucidal Activity: Molecular Modeling and Pharmacodynamic Studies by Mohamed Y. Zakaria, Paris E. Georghiou, Joseph H. Banoub, Botros Y. Beshay

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Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review by Milo Gatti, Milo Gatti, Federico Pea, Federico Pea

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