Search Results - "pharmacodynamics"

Prediction of a Therapeutic Dose for Buagafuran, a Potent Anxiolytic Agent by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Starting from Pharmacokinetics in Rats and Human by Fen Yang, Fen Yang, Baolian Wang, Zhihao Liu, Xuejun Xia, Weijun Wang, Dali Yin, Li Sheng, Yan Li

Connect to this object online.

Pharmacokinetics, Pharmacodynamics and Drug-Drug Interactions of New Anti-Migraine Drugs-Lasmiditan, Gepants, and Calcitonin-Gene-Related Peptide (CGRP) Receptor Monoclonal Antibodies by Danuta Szkutnik-Fiedler

Connect to this object online.

A Candidate Drug Screen Strategy: The Discovery of Oroxylin A in Scutellariae Radix Against Sepsis via the Correlation Analysis Between Plant Metabolomics and Pharmacodynamics by Lingyu Han, Yue Yuan, Xinyi Chen, Jian Huang, Jian Huang, Guan Wang, Chao Zhou, Jianjian Dong, Na Zhang, Yuxin Zhang, Hang Yin, Hang Yin, Yunyao Jiang

Connect to this object online.

Cepharanthine synergistically promotes methylprednisolone pharmacodynamics against human peripheral blood mononuclear cells possibly via regulation of P-glycoprotein/glucocorticoid receptor translocation by Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Jinwen Min, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano

Connect to this object online.

Development of a novel intramuscular liposomal injection for advanced meloxicam delivery: Preparation, characterization, in vivo pharmacokinetics, pharmacodynamics, and pain assessment in an orthopedic pain model by Pierre A. Hanna, Hatim A. Al-Abbadi, Mohamed A. Hashem, Aziza E. Mostafa, Yasmina K. Mahmoud, Eman A. Ahmed, Ibrahim M. Hegab, Ibrahim E. Helal, Mahmoud F. Ahmed

Connect to this object online.

Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8 by Andreas Port, Jamie V. Shaw, Lena Klopp‐Schulze, Afrim Bytyqi, Claudia Vetter, Elizabeth Hussey, Nadra Mammasse, Victor Ona, Angelika Bachmann, Denis Strugala, Christian Reh, Kosalaram Goteti

Connect to this object online.

Safety, Pharmacokinetics, and Pharmacodynamics of a Single Bolus of the γ-aminobutyric Acid (GABA) Receptor Potentiator HSK3486 in Healthy Chinese Elderly and Non-elderly by Xiaojiao Li, Deming Yang, Qianqian Li, Hong Wang, Meng Wang, Pangke Yan, Nan Wu, Fangqiong Li, Shiping Ma, Yanhua Ding, Jingrui Liu, Hushan Wang

Connect to this object online.

A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects by Park SI, Lee H, Oh J, Lim KS, Jang IJ, Kim JA, Jung JH, Yu KS

Connect to this object online.

A phase I randomized study to evaluate safety, pharmacokinetics, and pharmacodynamics of SIR2446M, a selective RIPK1 inhibitor, in healthy participants by Ana Liza Andresan Sun, John David Gillies, Yang Shen, Huajun Deng, Fenchao Xue, Yongfen Ma, Linan Song

Connect to this object online.

Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry by Jinpeng Zhang, Jinpeng Zhang, Xinyuan Cui, Shuo Zhao, Zenghui Chang, Junshuo Zhang, Yufeng Chen, Jiale Liu, Guohao Sun, Yiyuan Wang, Yuanyuan Liu

Connect to this object online.

A randomized, placebo‐controlled first‐in‐human study of oral TQS‐168 in healthy volunteers: Assessment of safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect by Jonas Hannestad, Steven Smith, Andrew Lam, Janet Hurt, Nicole Harada, Richard Kim, Abhirup Das, Juliana Brunello, Gareth Whitaker, David Chalmers, Faria Senjoti, Wu Lin, James Coghill, Yogesh Bansal, Sharan Sidhu, Vanessa Zann, Enchi Liu

Connect to this object online.

Pharmacokinetic/Pharmacodynamic Target Attainment of Ceftazidime in Adult Patients on General Wards with Different Degrees of Renal Function: A Prospective Observational Bicenter Cohort Study by Saskia E. Zieck, Suzanne L. de Vroom, Frouke Ph. Mulder, Gitte van Twillert, Ron A. A. Mathôt, Suzanne E. Geerlings, Reinier M. van Hest

Connect to this object online.

Safety, pharmacokinetics, and pharmacodynamics of anti‐IL‐4Rα antibody SHR‐1819 in healthy subjects: A randomized, controlled phase I study by Na Li, Sepehr Shakib, Weilin Qian, Xiaoyan Yao, Puyuan Li, Tsz Keung Nip, Xiaoyan Bai, Kai Shen

Connect to this object online.

A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody MK‐1654 in healthy Japanese adults by Yuji Orito, Naoyuki Otani, Yuki Matsumoto, Katsukuni Fujimoto, Nobuyuki Oshima, Brian M. Maas, Luzelena Caro, Antonios O. Aliprantis, Kara S. Cox, Osamu Tokumaru, Masaaki Kodama, Hideo Kudo, Hiromitsu Imai, Naoto Uemura

Connect to this object online.

Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein by Zheng Yang, James Loy, Brian Poirson, Yanshan Dai, Surendran Rajendran, Shihua Xu, Vanessa Spires, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Krishna Vasudevan, Thomas Spires, Ruslan Novosiadly, Shodeinde Coker, Raymond Perez, Kelly Covello, Paul Morin, Robert Graziano, Miranda Broz, Lois Lehman-McKeeman

Connect to this object online.

EFFECT OF GENES SLCO1B1 AND MDR1 POLYMORPHISM ON ATORVASTATIN PHARMACOKINETICS AND PHARMACODYNAMICS IN PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA: RESULTS OF PILOT PHARMACOGENETICS STUDY by A. V. Semenov, D. A. Sichev, V. G. Kukes

Connect to this object online.

Retrospective Assessment of Translational Pharmacokinetic-Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor by Anita Moein, Jin Y. Jin, Matthew R. Wright, Bruno Alicke, Harvey Wong

Connect to this object online.

Pharmacodynamics of Doripenem Alone and in Combination with Relebactam in an In Vitro Hollow-Fiber Dynamic Model: Emergence of Resistance of Carbapenemase-Producing <i>Klebsiella pneumoniae</i> and the Inoculum Effect by Elena N. Strukova, Maria V. Golikova, Svetlana A. Dovzhenko, Mikhail B. Kobrin, Stephen H. Zinner

Connect to this object online.

Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evaluation in rabbits by Asmaa Ashraf Nemr, Galal Mohamed El-Mahrouk, Hany Abdo Badie

Connect to this object online.

Understanding inter-individual variability in pharmacokinetics/pharmacodynamics of aripiprazole in children with tic disorders: Individualized administration based on physiological development and CYP2D6 genotypes by Yingying Xin, Liuliu Gao, Yali Tuo, Gang Nie, Yan Mei, Chen Chen, Jun Wang, Sichan Li, Dan Sun, Qiaoqiao Qian, Yongli Fu, Yang Wang, Zhisheng Liu

Connect to this object online.