Search Results - "pharmacodynamics"

A population pharmacokinetic‐pharmacodynamic model of YH12852, a highly selective 5‐hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation by Siun Kim, Hyun A. Lee, Seong Bok Jang, Howard Lee

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The effect of OCT-2 inhibitor Daclatasvir on Metformin pharmacokinetics and pharmacodynamics at two dose levels: A Bayesian approach using Markov-Chain Monte Carlo simulations by Mohamed Raslan, Lamia Elwakeel, Sara Shahin

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of aficamten in healthy Chinese participants: a randomized, double-blind, placebo-controlled, phase 1 study by Xue Zhao, Hongzhong Liu, Wei Tian, Ligang Fang, Mengyang Yu, Xiaofei Wu, Aijing Liu, Ruijie Wan, Li Li, Jinghui Luo, Yuqiong Li, Bo Liu, Yu He, Xiaowen Chen, Yuan Li, Donghong Xu, Hongyun Wang, Xiaohong Han

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Pharmacokinetics and Pharmacodynamics Estimation of Eculizumab in a 2-Year-Old Girl With Atypical Hemolytic Uremic Syndrome: A Case Report With 4-Year Follow-Up by Ken Saida, Tsuyoshi Fukuda, Kana Mizuno, Masao Ogura, Koichi Kamei, Shuichi Ito

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Pharmacodynamic Response to Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in a Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled Psoriasis Trial by Ian M. Catlett, Lu Gao, Yanhua Hu, Subhashis Banerjee, James G. Krueger

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Rituximab pharmacokinetic and pharmacokinetic-pharmacodynamic evaluation based on a study in diffuse large B‐cell lymphoma: Influence of tumor size on pharmacokinetic and assessment of pharmacokinetic similarity by Robin J. Svensson, Qing Xi Ooi, Lena E. Friberg, Narendra Maharaj, Pramod Kumar Reddy, Luis López‐Lázaro, Emma Hansson

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Population pharmacokinetic‐pharmacodynamic modeling of serum biomarkers as predictors of tumor dynamics following lenvatinib treatment in patients with radioiodine‐refractory differentiated thyroid cancer (RR‐DTC) by Oneeb Majid, Seiichi Hayato, Sree Harsha Sreerama Reddy, Bojan Lalovic, Taro Hihara, Taisuke Hoshi, Yasuhiro Funahashi, Jagadeesh Aluri, Osamu Takenaka, Sanae Yasuda, Ziad Hussein

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Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach by Shuaibing Liu, Ziteng Wang, Xin Tian, Weimin Cai

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Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model by Susanne Jacobsson, Daniel Golparian, Joakim Oxelbark, Francois Franceschi, David Brown, Arnold Louie, George Drusano, Magnus Unemo, Magnus Unemo

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Pharmacokinetics, pharmacodynamics, and safety of GS‐3583, a FLT3 agonist Fc fusion protein, from single‐ascending‐dose phase I study in healthy participants by Anees M. Dauki, Nishanthan Rajakumaraswamy, Torsten Trowe, Winnie Weng, Kai‐Wen Lin, Emon Elboudjwarej, Ann Ran‐Ran Qin, Christian Schwabe, Michelle R. Kuhne, Ahmed A. Othman

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Association between vancomycin pharmacokinetic/pharmacodynamic parameters, patient characteristics, and mortality in patients with bacteremia caused by vancomycin-susceptible Enterococcus faecium: a single-center retrospective study by Ichiro Nakakura, Kota Sakakura, Kaori Imanishi, Rumi Sako, Kunio Yamazaki

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Torsemide Pharmacometrics in Healthy Adult Populations Including CYP2C9 Genetic Polymorphisms and Various Patient Groups through Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling by Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee

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Author correction to 'Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors' [Acta Pharmaceutica Sinica B 8 (2018) 200-208] by Qing Chen, Ke Tang, Xiaoyu Zhang, Panpan Chen, Ying Guo

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Analysis of associations between pharmacodynamic genetic factors and antipsychotics' effectiveness and safety in adolescents with acute psychotic episodes taking antipsychotics during a 28-day follow-up by D. V. Ivaschenko, L. V. Fedina, N. I. Buromskaya, P. V. Shimanov, R. V. Deitsch, M. I. Nastovich, K. A. Akmalova, A. A. Kachanova, E. A. Grishina, L. M. Savchenko, Y. S. Shevchenko, D. A. Sychev

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Using real-world data to inform dosing strategies of rituximab for pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome: a prospective pharmacokinetic-pharmacodynamic study by Yewei Chen, Qian Shen, Ye Xiong, Min Dong, Min Dong, Hong Xu, Zhiping Li

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Pharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions by Lee HW, Kang WY, Jung W, Gwon MR, Cho K, Yoon YR, Seong SJ

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Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T by Aman P. Singh, Wenbo Chen, Xirong Zheng, Hardik Mody, Thomas J. Carpenter, Alice Zong, Donald L. Heald

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In silico evaluation of the pharmacodynamic component of the interaction of S-alkyl derivatives of 5-methyl-4-(p-tolyl)-1,2,4-triazole-3-thiol with some biological targets by O. I. Panasenko, V. M. Odyntsova, A. S. Hotsulia

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Pharmacokinetic/Pharmacodynamic (PK/PD) Simulation for Dosage Optimization of Colistin Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i> and Carbapenem-Resistant <i>Escherichia coli</i> by Kamonchanok Jitaree, Korbtham Sathirakul, Jantana Houngsaitong, Orarik Asuphon, Weerayuth Saelim, Visanu Thamlikitkul, Preecha Montakantikul

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Pharmacokinetics, Pharmacodynamics, and Safety of Evocalcet (KHK7580), a Novel Calcimimetic Agent: An Open-Label, Single- and Multiple-Dose, Phase I Trial in Healthy Chinese Subjects by He X, Narushima K, Kojima M, Nagai C, Li K

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