Search Results - "pharmacokinetics"

Safety, Tolerability, and Pharmacokinetics of Ibuprofenamine Hydrochloride Spray (NSAIDs), a New Drug for Rheumatoid Arthritis and Osteoarthritis, in Healthy Chinese Subjects by Xie P, Xue W, Qi W, Li Y, Yang L, Yang Z, Shi A

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A Phase I Study to Investigate the Safety, Tolerability and Pharmacokinetics of Napabucasin Combined with Sorafenib in Japanese Patients with Unresectable Hepatocellular Carcinoma by Takuji Okusaka, Manabu Morimoto, Yuichiro Eguchi, Shinichiro Nakamura, Shuichi Iino, Rie Kageyama

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Population pharmacokinetics and exposure‐response analysis of a single dose of sotrovimab in the early treatment of patients with mild to moderate COVID‐19 by Jennifer E. Sager, Asma El‐Zailik, Julie Passarell, Stefan Roepcke, Xiaobin Li, Melissa Aldinger, Ahmed Nader, Andrew Skingsley, Elizabeth L. Alexander, Wendy W. Yeh, Erik Mogalian, Chad Garner, Amanda Peppercorn, Adrienne E. Shapiro, Maribel Reyes

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Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway by Pengfei Li, Jun Peng, Yuexin Li, Lili Gong, Yali Lv, He Liu, Tianhong Zhang, Song Yang, Hongchuan Liu, Jinglai Li, Lihong Liu

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Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone by Simeon Rüdesheim, Dominik Selzer, Thomas Mürdter, Svitlana Igel, Reinhold Kerb, Matthias Schwab, Thorsten Lehr

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Simultaneous determination of four Sudan dyes in rat blood by UFLCâMS/MS and its application to a pharmacokinetic study in rats by Hao Zhu, Yijun Chen, Changshun Huang, Yangyang Han, Yiwei Zhang, Shucan Xie, Xiaohong Chen, Micong Jin

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Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months? by Yoann Cazaubon, Yohann Talineau, Catherine Feliu, Céline Konecki, Jennifer Russello, Olivier Mathieu, Zoubir Djerada

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Consideration of a Credibility Assessment Framework in Model‐Informed Drug Development: Potential Application to Physiologically‐Based Pharmacokinetic Modeling and Simulation by Colleen Kuemmel, Yuching Yang, Xinyuan Zhang, Jeffry Florian, Hao Zhu, Million Tegenge, Shiew‐Mei Huang, Yaning Wang, Tina Morrison, Issam Zineh

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Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions by Simeon Rüdesheim, Jan-Georg Wojtyniak, Dominik Selzer, Nina Hanke, Felix Mahfoud, Matthias Schwab, Thorsten Lehr

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Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens by Kyo Won Lee, Tae Hwan Kim, Jong Bong Lee, Kyeong Sik Kim, Jae Berm Park, Pavel Gershkovich, Sun Dong Yoo, Soyoung Shin, Beom Soo Shin, Sung Joo Kim

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Evaluation of Safety, Tolerability and Pharmacokinetic Characteristics of SA001 and Its Active Metabolite Rebamipide after Single and Multiple Oral Administration by Sungyeun Bae, Ki Young Huh, Jaeseong Oh, Kyung-Sang Yu, Anhye Kim

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Population pharmacokinetics, enzyme occupancy, and 24S‐hydroxycholesterol modeling of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, in healthy adults by Wei Yin, Axel Facius, Thomas Wagner, Max Tsai, Mahnaz Asgharnejad, Gëzim Lahu, Majid Vakilynejad

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A dose‐adjusted, open‐label, pilot study of the safety, tolerability, and pharmacokinetics of STC3141 in critically ill patients with sepsis by Rinaldo Bellomo, John Patava, Ruth Van Lancker, Nathalie Layios, Marijke Peetermans, Mark Plummer, Rachid Attou, Robert McNamara, Andrew Udy, Bradley Wibrow, Adam Deane, Edward Litton, Marcel Tanudji, Fuhong Su, Zhang Zhong, Linda Shi, Li Ning

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Pharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study by Wang X, Wang Y, Yao F, Chen S, Hou Y, Zheng Z, Luo J, Qiu B, Li Z, Wang Y, Wu Z, Lan J, Chen C

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Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LCâMS/MS: Method development, validation and application to pharmacokinetics by Xiao-Jiao Li, Yan-Tong Sun, Lei Yin, Xue-Ju Zhang, Yan Yang, J. Paul Fawcett, Yi-Min Cui, Jing-Kai Gu

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The Effect of Dihydromyricetin on the Pharmacokinetics of Fluconazole in Sprague-Dawley Rat Plasma, Based on High-Performance Liquid Chromatography–Tandem Mass Spectrometry by Liu H, Dong H, Guo L, Jin Y, Liu L

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Pharmacological Activity, Pharmacokinetics, and Toxicity of Timosaponin AIII, a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review by Yan Lin, Yan Lin, Wai-Rong Zhao, Wen-Ting Shi, Jing Zhang, Kai-Yu Zhang, Qian Ding, Xin-Lin Chen, Jing-Yi Tang, Zhong-Yan Zhou, Zhong-Yan Zhou

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Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study by Wang J, Huang J, Yang S, Cui C, Ye L, Wang S, Yang G, Pei Q

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Bioanalytical method for the simultaneous estimation of atoltivimab, maftivimab and odesivimab in rat plasma by LCMS/MS and its application to a pharmacokinetic study by Ibrahim Baje Syed, Madhavi Nannapaneni

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Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects by Sidharta PN, Melchior M, Kankam MK, Dingemanse J

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