Search Results - "pharmacokinetics"

First-In-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, a Small-Molecule Factor XIa Inhibitor in Healthy Subjects by Rui Chen, Xiaoduo Guan, Pei Hu, Yanli Dong, Yi Zhu, Tengfei Zhang, Jianjun Zou, Shuyang Zhang

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Stability Study, Quantification Method and Pharmacokinetics Investigation of a Coumarin-Monoterpene Conjugate Possessing Antiviral Properties against Respiratory Syncytial Virus by Arina G. Nemolochnova, Artem D. Rogachev, Olga P. Salnikova, Tatyana M. Khomenko, Konstantin P. Volcho, Olga I. Yarovaya, Alina V. Fatianova, Andrey G. Pokrovsky, Nariman F. Salakhutdinov

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Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4 by Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, William G. Darby, Chris G. Hosking, Lionel Renaud, Matthias Machacek, Peter Lloyd, Arne Skerra, Michael Foley

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Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles by Huang X, Zhang S, Ma Y, Yang H, He C, Tian R, Mei H, Liu L, Zhang B

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Population pharmacokinetics and exposure-response analyses of SAF-189s in Chinese patients with ALK+/ROS1+ non-small cell lung cancer by Yinhui Liu, Yinhui Liu, Yan Tan, Lin Hu, Jinlong Li, Jiansong Yang, Lei Diao, Jin Yang

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Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases by Ekpenyong O, Gao X, Ma J, Cooper C, Nguyen L, Olaleye OA, Liang D, Xie H

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Simultaneous determination of three major bioactive saponins of <it>Panax notoginseng </it>using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study by Zhu Chunyan, Dang Yunjie, Chen Wei

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First‐in‐human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC‐2394, in healthy volunteers by Fei Tang, Rebecca Kunder, Tom Chu, Avis Hains, Allen Nguyen, Jacqueline M. McBride, Yu Zhong, Sara Santagostino, Maria Wilson, Abigail Trenchak, Liuxi Chen, Justin Ly, Anita Moein, Nicholas Lewin‐Koh, Vibha Raghavan, Uyi Osaghae, Chris Wynne, Ryan Owen, David Place

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In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer by Lawal B, Kuo YC, Sumitra MR, Wu ATH, Huang HS

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First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers by Lisa M. Pitchford, John A. Rathmacher, John C. Fuller, J. Scott Daniels, Ryan D. Morrison, Wendall S. Akers, Naji N. Abumrad, Venkataraman Amarnath, Patricia M. Currey, L. Jackson Roberts, John A. Oates, Olivier Boutaud

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Monitoring of Ex Vivo Cyclosporin a Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics by Aliede E. in 't Veld, Manon A. A. Jansen, Bertine W. Huisman, Mascha Schoonakker, Marieke L. de Kam, Dirk Jan A. R. Moes, Mariëtte I. E. van Poelgeest, Jacobus Burggraaf, Matthijs Moerland

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A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults by Jihyun Jung, Ki Young Huh, Xuanyou Jin, Ahnul Ha, Ki Ho Park, Jun Sang Park, Eunjung Kim, Jaehwi Lee, In‐Jin Jang, Howard Lee

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Pharmacokinetic predictions and docking studies of substituted aryl amine-based triazolopyrimidine designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) by Zakari Ya'u Ibrahim, Adamu Uzairu, Gideon Adamu Shallangwa, Stephen Eyije Abechi

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Factors Contributing to Drug Release From Enteric-Coated Omeprazole Capsules: An In Vitro and In Vivo Pharmacokinetic Study and IVIVC Evaluation in Beagle Dogs by Cheng Cui, Jiabei Sun, Xueqing Wang, Zhenxi Yu, Yaqin Shi

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Safety, tolerability, and pharmacokinetics of single and multiple ascending Oral doses of DA‐8010 in healthy subjects: First‐in‐human phase I study by Dae Young Lee, Min Jung Lee, Chaelim Ryu, Heewon Lee, Ashley Brooks

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Dalbavancin, Vancomycin and Daptomycin Alone and in Combination with Cefazolin against Resistant Phenotypes of <i>Staphylococcus aureus</i> in a Pharmacokinetic/Pharmacodynamic Model by Jacinda C. Abdul-Mutakabbir, Razieh Kebriaei, Kyle C. Stamper, Zain Sheikh, Philip T. Maassen, Katherine L. Lev, Michael J. Rybak

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Loading Dose of Ceftazidime Needs to Be Increased in Critically Ill Patients: A Retrospective Study to Evaluate Recommended Loading Dose with Pharmacokinetic Modelling by Manon Launay, Edouard Ollier, Benjamin Kably, Félicien Le Louedec, Guillaume Thiery, Julien Lanoiselée, Sophie Perinel-Ragey

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Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets by Muhammad Faisal, Willi Cawello, Bjoern B. Burckhardt, Jan de Hoon, Stephanie Laer, LENA Consortium

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A randomized, placebo‐controlled study to evaluate safety and pharmacokinetics of ART‐001 with a novel oral pediatric formulation in healthy subjects by Akira Tanaka, Naoto Uemura, Kanako Kuniyeda, Haruhi Ando, Toshinori Higashi, Hiroshi Nagabukuro

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Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells by Yoon-Jee Chae, Min-Soo Kim, Suk-Jae Chung, Mi-Kyung Lee, Kyeong-Ryoon Lee, Han-Joo Maeng

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