Search Results - "pharmacokinetics"

Design and optimization of piperidine-substituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles by Yanying Sun, Zhenzhen Zhou, Zhongling Shi, Fabao Zhao, Minghui Xie, Zongji Zhuo, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu

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First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of a Neuroprotective Poly (ADP‐ribose) Polymerase‐1 Inhibitor, JPI-289, in Healthy Volunteers by Han S, Kim YH, Choi HY, Soh DJ, Kim J, Nam J, Kim JW, Bae KS, Lim HS

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Probability of Target Attainment of Tobramycin Treatment in Acute and Chronic <i>Pseudomonas aeruginosa</i> Lung Infection Based on Preclinical Population Pharmacokinetic Modeling by Bruna Bernar Dias, Fernando Carreño, Victória Etges Helfer, Priscila Martini Bernardi Garzella, Daiane Maria Fonseca de Lima, Fabiano Barreto, Bibiana Verlindo de Araújo, Teresa Dalla Costa

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of HBM9161, a novel FcRn inhibitor, in a phase I study for healthy Chinese volunteers by Desmond Y. H. Yap, Jojo Hai, Paul C. H. Lee, Xueying Zhou, Michael Lee, Yu Zhang, Meng Wang, Xiaoxiang Chen

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Is Dosing of Ethambutol as Part of a Fixed-Dose Combination Product Optimal for Mechanically Ventilated ICU Patients with Tuberculosis? A Population Pharmacokinetic Study by Francisco Beraldi-Magalhaes, Suzanne L. Parker, Cristina Sanches, Leandro Sousa Garcia, Brenda Karoline Souza Carvalho, Mariana Millan Fachi, Marcus Vinicius de Liz, Roberto Pontarolo, Jeffrey Lipman, Marcelo Cordeiro-Santos, Jason A. Roberts

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Metabolic profiling and pharmacokinetic studies of Baihu-Guizhi decoction in rats by UFLC-Q-TOF-MS/MS and UHPLC-Q-TRAP-MS/MS by Yan He, Zhenkun Zhou, Weijie Li, Yanqiong Zhang, Ruoyao Shi, Tao Li, Linlin Jin, Hongliang Yao, Na Lin, Hao Wu

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Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects by Ai Goto, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama

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Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Piperacillin-Tazobactam or Meropenem and Microbiological Outcome among Urologic Patients with Documented Gram-Negative Infections by Pasquale Maria Berrino, Milo Gatti, Matteo Rinaldi, Eugenio Brunocilla, Pierluigi Viale, Federico Pea

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Pharmacokinetics, safety, and efficacy of Fuqi Guben Gao in the treatment of kidney-yang deficiency syndrome: a randomized, double-blind phase I trial by Wei-Yi Cao, Wei-Yi Cao, Jun-Yu Liu, Jun-Yu Liu, Min Sun, Min Sun, Jing-Kun Wang, Jing-Kun Wang, Fang Lu, Fang Lu, Qiao-Ning Yang, Qiao-Ning Yang, Wan-Tong Zhang, Wan-Tong Zhang, Ming-Jie Zi, Ming-Jie Zi, Bai-E Zhang, Bai-E Zhang, Hong-Bin Liu, Hong-Bin Liu, Shu-Ge Wang, Shu-Ge Wang, Yi Wu, Yi Wu, Rong-Zu Wu, Wen-Di Wu, Rui Li, Rui Li, Zhao-Yun Zhu, Zhao-Yun Zhu, Rui Gao, Rui Gao

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First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers by Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Dolores Ochoa, Gina Mejía-Abril, Manuel Román, Paola Camargo-Mamani, Sergio Luquero-Bueno, Bernd Jilma, María A. Moro, Gerónimo Fernández, David Piñeiro, Marc Ribó, Víctor M. González, Ignacio Lizasoain, Francisco Abad-Santos

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Comparison of pharmacokinetics and drug release in tissues after transarterial chemoembolization with doxorubicin using diverse lipiodol emulsions and CalliSpheres Beads in rabbit livers by Shuisheng Zhang, Can Huang, Zhengzheng Li, Yongjie Yang, Tingting Bao, Haibo Chen, Yinghua Zou, Li Song

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Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kg_bw Following Intramuscular Administration by Zoltán Somogyi, Patrik Mag, Réka Simon, Ádám Kerek, Pál Szabó, Ervin Albert, Imre Biksi, Ákos Jerzsele

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Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects by Natalia Guevara, Cecilia Maldonado, Manuel Uría, Raquel González, Manuel Ibarra, Silvana Alvariza, Antonella Carozzi, Carlos Azambuja, Pietro Fagiolino, Marta Vázquez

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Safety, pharmacokinetics, and pharmacodynamics of ART‐648, a PDE4 inhibitor in healthy subjects: A randomized, placebo‐controlled phase I study by Akira Tanaka, Hiroshi Nagabukuro, Kanako Kuniyeda, Haruhi Ando, Toshinori Higashi, Hirokazu Wakuda, Naoyuki Otani, Hideo Kudo, Masae Kuranari, Hidetoshi Furuie, Naoto Uemura

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Commentary: Reduction in C-Peptide Levels and Influence on Pharmacokinetics and Pharmacodynamics of Insulin Preparations: How to Conduct a High-Quality Euglycemic Clamp Study by Hui Liu, Hongling Yu, Ting Li, Yerong Yu

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Artificial Intelligence to Close the Gap between Pharmacokinetic/Pharmacodynamic Targets and Clinical Outcomes in Critically Ill Patients: A Narrative Review on Beta Lactams by João Gonçalves Pereira, Joana Fernandes, Tânia Mendes, Filipe André Gonzalez, Susana M. Fernandes

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Minimal Physiologically-Based Pharmacokinetic (mPBPK) Metamodeling of Target Engagement in Skin Informs Anti-IL17A Drug Development in Psoriasis by Vivaswath S. Ayyar, Jong Bong Lee, Weirong Wang, Meghan Pryor, Yanli Zhuang, Thomas Wilde, An Vermeulen, An Vermeulen

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Evaluation of pharmacological and pharmacokinetic herb-drug interaction between irinotecan hydrochloride injection and Kangai injection in colorectal tumor-bearing mice and healthy rats by Yanfei Chen, Yanfei Chen, Zhaoliang Hu, Jing Jiang, Chenxi Liu, Shuxiao Gao, Min Song, Taijun Hang

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Potential pharmacokinetic interactions with concurrent use of herbal medicines and a ritonavir-boosted COVID-19 protease inhibitor in low and middle-income countries by Dallas J. Smith, Dallas J. Smith, Huichang Bi, Josias Hamman, Xiaochao Ma, Constance Mitchell, Kumbukani Nyirenda, Tsitsi Monera-Penduka, Hellen Oketch-Rabah, Mary F. Paine, Syril Pettit, Wihan Pheiffer, Richard B. Van Breemen, Michelle Embry

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A Phase I Clinical Study Comparing the Tolerance, Immunogenicity, and Pharmacokinetics of Proposed Biosimilar BAT1806 and Reference Tocilizumab in Healthy Chinese Men by Hong Zhang, Hong Wang, Haijing Wei, Hong Chen, Jingrui Liu, Cuiyun Li, Xiaoxue Zhu, Xiaojiao Li, Jinchen Yu, Yinbo Zhou, Xiaolei Yang, Zhaohe Wang, Min Wu, Yanhua Ding

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