Search Results - "pharmacokinetics"

Pharmacokinetic and Biomarker Quantification Studies on Vancomycin-Loaded PEGylated Liposomes and Its Potential to Reduce Vancomycin-Induced Kidney Injury: A Rat Study by Medha D. Joshi, Paulina Iacoban, Marc H. Scheetz

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Comparative pharmacokinetics and pharmacodynamics of a PEGylated recombinant human growth hormone and daily recombinant human growth hormone in growth hormone-deficient children by Hou L, Chen ZH, Liu D, Cheng YG, Luo XP

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Physiologically‐Based Pharmacokinetic Modeling for the Prediction of a Drug-Drug Interaction of Combined Effects on P‐glycoprotein and Cytochrome P450 3A by Yukio Otsuka, Mary P. Choules, Peter L. Bonate, Kanji Komatsu

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A Novel Antibiotic, Rhodomyrtone: Pharmacokinetic Studies in a Murine Model and Optimization and Validation of High-Performance Liquid Chromatographic Method for Plasma Analysis by Tan Suwandecha, Boon-Ek Yingyongnarongkul, Kanokkan Towtawin, Supayang Piyawan Voravuthikunchai, Somchai Sriwiriyajan

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Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics by Camille Lenoir, Amine Niederer, Victoria Rollason, Jules Alexandre Desmeules, Youssef Daali, Caroline Flora Samer

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Bio-analytical method development and validation of Rasagiline by high performance liquid chromatography tandem mass spectrometry detection and its application to pharmacokinetic study by Ravi Kumar Konda, Babu Rao Chandu, B.R. Challa, Chandrasekhar B. Kothapalli

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Quantification of imatinib in human serum: validation of a high-performance liquid chromatography-mass spectrometry method for therapeutic drug monitoring and pharmacokinetic assays by Rezende VM, Rivellis A, Novaes MM, Chamone DA, Bendit I

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Unraveling the interconversion pharmacokinetics and oral bioavailability of the major ginger constituents: [6]-gingerol, [6]-shogaol, and zingerone after single-dose administration in rats by Phanit Songvut, Watanyoo Nakareangrit, Wanida Cholpraipimolrat, Jackapun Kwangjai, Luksamee Worasuttayangkurn, Piyajit Watcharasit, Piyajit Watcharasit, Jutamaad Satayavivad, Jutamaad Satayavivad

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Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug-drug interactions from coproporphyrin I to probe drugs by Tatsuki Mochizuki, Yasunori Aoki, Takashi Yoshikado, Kenta Yoshida, Yurong Lai, Hideki Hirabayashi, Yoshiyuki Yamaura, Kevin Rockich, Kunal Taskar, Tadayuki Takashima, Xiaoyan Chu, Maciej J. Zamek‐Gliszczynski, Jialin Mao, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara

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Pharmacokinetics, Safety, and Preliminary Efficacy of Oral Trifluridine/Tipiracil in Chinese Patients with Solid Tumors: A Phase 1b, Open-Label Study by Wang X, Zhou J, Li Y, Ge Y, Zhou Y, Bai C, Shen L

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Evaluation of the Drug-Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP‐5862, Using a Physiologically‐Based Pharmacokinetic Modeling Approach by Diansong Zhou, Terry Podoll, Yan Xu, Ganesh Moorthy, Karthick Vishwanathan, Joseph Ware, J. Greg Slatter, Nidal Al‐Huniti

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Population pharmacokinetic-pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers by Steven J. Kathman, Jeffery J. Wheeler, Deepak L. Bhatt, Susan E. Arnold, John S. Lee

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Pharmacokinetics and Safety of Rifamycin SV after Single and Multiple Doses of MMX^® Modified Release Tablets in Healthy Male and Female Volunteers by Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Angelo Vaccani, Alessandro Mazzetti, Luigi Maria Longo, Luigi Moro

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Assessing CYP2C19 Ontogeny in Neonates and Infants Using Physiologically Based Pharmacokinetic Models: Impact of Enzyme Maturation Versus Inhibition by Peng Duan, Fang Wu, Jason N. Moore, Jeffrey Fisher, Victor Crentsil, Daniel Gonzalez, Lei Zhang, Gilbert J. Burckart, Jian Wang

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Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS‐441524 in patients with COVID‐19: A limited case series by Pyoeng Gyun Choe, Sae Im Jeong, Chang Kyung Kang, Liju Yang, SeungHwan Lee, Joo‐Youn Cho, Seung Seok Han, Dong Ki Kim, Sang Min Lee, Wan Beom Park, Myoung‐don Oh, Nam Joong Kim

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Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects by Susan Bellaire, Mark Walzer, Tianli Wang, Walter Krauwinkel, Nancy Yuan, Gerard J. Marek

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Evaluation of the multiple doses thiozonide's pharmacokinetics in patients diagnosed with pulmonary tuberculosis with multidrug-resistant or extensively drug-resistant <i>Mycobacterium tuberculosis</i> by А. Yu. Savchenko, V. G. Kukes, M. S. Burenkov, G. V. Ramenskaya

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Pharmacokinetic Simulation Study: Exploring the Impact of Clinical Parameters on Lamotrigine for Different Patient Populations with Implications for Liver Function Assessment and Therapeutic Drug Monitoring by Bárbara Costa, Isabel Silva, José Carlos Oliveira, Henrique Reguengo, Nuno Vale

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study by Gordon D, Hellriegel ET, Hope HR, Burt D, Monahan JB

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Effect of Food on the Pharmacokinetics and Safety of a Novel c-Met Inhibitor SCC244: A Randomized Phase I Study in Healthy Subjects by Wu J, Xu H, Li H, Ma L, Chen J, Yuan F, Sheng L, Liu C, Chen W, Li X

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