Search Results - "pharmacokinetics"

First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring by Willem de Laat, Lisa Pagan, R. Karl Malcolm, Maarten Wiegerinck, Victor Nickolson, Bertine Huisman, Rik Stuurman, Michiel van Esdonk, Naomi Klarenbeek

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Real Life Population Pharmacokinetics Modelling of Eight Factors VIII in Patients with Severe Haemophilia A: Is It Always Relevant to Switch to an Extended Half-Life? by Quentin Allard, Zoubir Djerada, Claire Pouplard, Yohann Repessé, Dominique Desprez, Hubert Galinat, Birgit Frotscher, Claire Berger, Annie Harroche, Anne Ryman, Claire Flaujac, Pierre Chamouni, Benoît Guillet, Fabienne Volot, Jean Szymezak, Philippe Nguyen, Yoann Cazaubon

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The Clinical Pharmacokinetics and Pharmacodynamics of Warfarin When Combined with Compound Danshen: A Case Study for Combined Treatment of Coronary Heart Diseases with Atrial Fibrillation by Chunxiao Lv, Changxiao Liu, Zhuhua Yao, Xiumei Gao, Lanjun Sun, Jia Liu, Haibo Song, Ziqiang Li, Xi Du, Jinxia Sun, Yanfen Li, Kui Ye, Ruihua Wang, Yuhong Huang

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Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach by Kanwal U, Mukhtar S, Waheed M, Mehreen A, Abbas N, Shamim R, Hussain K, Rasool F, Hussain A, Bukhari NI

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β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation by Nadia Shamshad Malik, Mahmood Ahmad, Mohammed S. Alqahtani, Arshad Mahmood, Kashif Barkat, Muhammad Tariq Khan, Ume Ruqia Tulain, Ayesha Rashid

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A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects by Qian Chen, Qian Chen, Qian Chen, Qingqing Wu, Qingqing Wu, Qingqing Wu, Rong Song, Rong Song, Rong Song, Yating Wang, Yating Wang, Yating Wang, Mengqi Zhang, Mengqi Zhang, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Wei Wang, Wei Wang, Jingying Jia, Jingying Jia, Jingying Jia, Chen Yu, Chen Yu, Chen Yu, Yanmei Liu, Yanmei Liu, Yanmei Liu

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Evaluation of the relationship between polymorphisms in CYP2C19 and the single‐dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study by Shuang Zhou, Ran Xie, Xiaodan Zhang, Xu He, Jie Huang, Yin Jungang, Man Liao, Ying Ding, Dandan Yang, Ying Liu, Qian Zhang, Guoping Yang, Fang Liu, Shengjiang Guan, Qing He, Honggang Lou, Fengyun Gong, Xianmin Meng, Qian Xiang, Xia Zhao, Yimin Cui

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Using a State-Bounding Observer to Predict the Guaranteed Limits of Drug Amounts in Rats after Oral Administration Based on an Uncertain Pharmacokinetic Model by Zuzana Vitková, Martin Dodek, Jarmila Pavlovičová, Anton Vitko

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Pharmacokinetics of Piperacillin-Tazobactam in Critically Ill Patients with Open Abdomen and Vacuum-Assisted Wound Closure: Dosing Considerations Using Monte Carlo Simulation by Cédric Carrié, Jesse Butruille, Sophie Maingault, Alexandre Lannou, Vincent Dubuisson, Laurent Petit, Matthieu Biais, Dominique Breilh

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Pharmacokinetics and Bioequivalence of Abiraterone Acetate Tablets in Healthy Chinese Volunteers: An Open, Randomized, Single-Dose, Three-Period, Three-Sequence Crossover Study by Zhao-xin Wu, Chen-jing Wang, Ping Shi, Yan-ping Liu, Ting Li, Fei-fei Sun, Yao Fu, Xiao-meng Gao, Ya-ping Ma, Yu Cao

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Towards a Generic Tool for Prediction of Meropenem Systemic and Infection-Site Exposure: A Physiologically Based Pharmacokinetic Model for Adult Patients with Pneumonia by Pauline Thémans, Pierre Marquet, Joseph J. Winkin, Flora T. Musuamba

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Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings by Jie Li, Jie Li, Jie Li, Xin Li, Xin Li, Xin Li, Yu-Shan Ren, Yu-Shan Ren, Yuan-Yuan Lv, Yuan-Yuan Lv, Yuan-Yuan Lv, Jun-Sheng Zhang, Jun-Sheng Zhang, Jun-Sheng Zhang, Xiao-Li Xu, Xiao-Li Xu, Xiao-Li Xu, Xian-Zhen Wang, Xian-Zhen Wang, Xian-Zhen Wang, Jing-Chun Yao, Jing-Chun Yao, Jing-Chun Yao, Gui-Min Zhang, Gui-Min Zhang, Zhong Liu, Zhong Liu

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Body Surface Area-Based Dosing of Mycophenolate Mofetil in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Prospective Population Pharmacokinetic Study by Hyun Jin Park, Kyung Taek Hong, Nayoung Han, In-Wha Kim, Jung Mi Oh, Hyoung Jin Kang

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First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator by Sebastiaan J. W. vanKraaij, Pim Gal, Laura G. J. M. Borghans, Erica S. Klaassen, Francis Dijkstra, Christopher Winrow, Chad Glasser, Geert Jan Groeneveld

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Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis by Huang Z, Li H, Zhang Q, Tan X, Lu F, Liu H, Li S

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Evaluating the Therapeutic Efficacy of Si-Wu-Tang Decoction and Concentrated Extract in Follicular Maldevelopment-Related Menstrual Disorders Through Pharmacokinetic/Pharmacodynamic Studies by Chia-Jung Lee, Chia-Jung Lee, Chia-Jung Lee, Alinafe Magret Kapelemera, Yi-Zhe Tsai, Ching-Tzu Lee, Ming-Yi Xu, Ching-Chiung Wang, Ching-Chiung Wang, Ching-Chiung Wang, Ching-Chiung Wang

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Correction to: Views, knowledge, and practices of hospital pharmacists about using clinical pharmacokinetics to optimize pharmaceutical care services: a cross-sectional study by Ramzi Shawahna, Naser Shraim, Rafeef Aqel

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Case report of pharmacokinetic analysis of continuous intravenous infusion of fentanyl in a patient with severe burn: burn shock stage complicates pain management by Takafumi Nakano, Yasuhisa Oida, Shinichi Morimoto, Kentaro Muranishi, Soichiro Ushio, Takuya Yamashina, Masanobu Uchiyama, Kenichi Mishima, Kiyoyuki Kitaichi, Yoshihiko Nakamura, Koichi Matsuo

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First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects by Jing Yang, Jason D. Lickliter, Jan L. Hillson, Gary D. Means, Russell J. Sanderson, Kay Carley, Almudena Tercero, Kristi L. Manjarrez, Jennifer R. Wiley, Stanford L. Peng

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Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder by Ramakanth Gundu, Sanjay Pekamwar, Santosh Shelke, Deepak Kulkarni, Santosh Shep

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