Search Results - "pharmacokinetics"

When Bioequivalence in Healthy Volunteers May not Translate to Bioequivalence in Patients: Differential Effects of Increased Gastric pH on the Pharmacokinetics of Levothyroxine Capsules and Tablets by Corinne Seng Yue, Salvatore Benvenga, Claudia Scarsi, Luca Loprete, Murray Ducharme

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Pharmacokinetics of fluorobenzyl polyethylene glycol conjugated tetraiodothyroacetic acid (NP751), a novel anticancer thyrointegrin αvβ3 antagonist by Kazutoshi Fujioka, Bruce A. Hay, Kavitha Godugu, Shaker A. Mousa

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A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects by Kim YK, Choi MJ, Oh TY, Yu KS, Lee S

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Impact of Albumin and Omeprazole on Steady-State Population Pharmacokinetics of Voriconazole and Development of a Voriconazole Dosing Optimization Model in Thai Patients with Hematologic Diseases by Buddharat Khan-asa, Baralee Punyawudho, Noppaket Singkham, Piyawat Chaivichacharn, Ekapun Karoopongse, Preecha Montakantikul, Methee Chayakulkeeree

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A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteers by Marie A. Printz, BA, Samuel S. Dychter, MD, Emanuel P. DeNoia, MD, Rena Harrigan, MPH, Barry J. Sugarman, PhD, Monica Zepeda, PhD, Jennifer Souratha, BSc, David W. Kang, BSc, Daniel C. Maneval, PhD

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A target‐mediated drug disposition population pharmacokinetic model of GC1118, a novel anti‐EGFR antibody, in patients with solid tumors by Tae Kyu Chung, Hyun A. Lee, Sang‐In Park, Do‐Youn Oh, Keun‐Wook Lee, Jin Won Kim, Jee Hyun Kim, Ahmi Woo, Su Jin Lee, Yung‐Jue Bang, Howard Lee

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Pharmacokinetic/Pharmacodynamic Target Attainment Based on Measured versus Predicted Unbound Ceftriaxone Concentrations in Critically Ill Patients with Pneumonia: An Observational Cohort Study by Matthias Gijsen, Erwin Dreesen, Ruth Van Daele, Pieter Annaert, Yves Debaveye, Joost Wauters, Isabel Spriet

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Development and validation of bioanalytical UHPLC-UV method for simultaneous analysis of unchanged fenofibrate and its metabolite fenofibric acid in rat plasma: Application to pharmacokinetics by Rayan G. Alamri, Kazi Mohsin, Ajaz Ahmad, Mohammad Raish, Fars K. Alanazi

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Design, Characterization and Pharmacokinetic-Pharmacodynamic Evaluation of Poloxamer and Kappa-Carrageenan-Based Dual-Responsive In Situ Gel of Nebivolol for Treatment of Open-Angle Glaucoma by Pradeep Singh Rawat, Punna Rao Ravi, Shahid Iqbal Mir, Mohammed Shareef Khan, Himanshu Kathuria, Prasanna Katnapally, Upendra Bhatnagar

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Pharmacogenetics-based population pharmacokinetic analysis and dose optimization of valproic acid in Chinese southern children with epilepsy: Effect of ABCB1 gene polymorphism by Xianhuan Shen, Xianhuan Shen, Xinyi Chen, Jieluan Lu, Jieluan Lu, Qing Chen, Wenzhou Li, Jiahao Zhu, Jiahao Zhu, Yaodong He, Yaodong He, Huijuan Guo, Chenshu Xu, Xiaomei Fan

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Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-Quinone by Monika Kadela-Tomanek, Maria Jastrzębska, Krzysztof Marciniec, Elwira Chrobak, Ewa Bębenek, Stanisław Boryczka

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Effect of Food on the Pharmacokinetics of Tenofovir Amibufenamide: A Phase I, Randomized, Open-Label, Two-Period Crossover Trial in Healthy Adult Subjects by Liu J, Wu M, Kai J, Lin M, Zheng Y, Jiang Y, Huang Q, Zhai Y, Qiu Y

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A Phase I Comparative Pharmacokinetic and Safety Study of Two Intravenous Formulations of Vinorelbine in Patients With Advanced Non-Small Cell Lung Cancer by Guolan Wu, Guolan Wu, Lihua Wu, Lihua Wu, Huili Zhou, Huili Zhou, Meihua Lin, Meihua Lin, Ling Peng, Yina Wang, You Zhai, You Zhai, Xingjiang Hu, Xingjiang Hu, Yunliang Zheng, Yunliang Zheng, Duo Lv, Duo Lv, Jian Liu, Jian Liu, Jianzhong Shentu, Jianzhong Shentu

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Pharmacodynamics and Pharmacokinetics of a New Type of Compound Lansoprazole Capsule in Gastric Ulcer Rats and Beagle Dogs: Importance of Adjusting Oxidative Stress and Inflammation by Binbin Wei, Yan Wang, Huizhe Wu, Mingyan Liu, Weifan Yao, Minjie Wei

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A Highly Sensitive Nonextraction-Assisted HPLC Method with Fluorescence Detection for Quantification of Duvelisib in Plasma Samples and its Application to Pharmacokinetic Study in Rats by Sayed AY, Khalil NY, Almomen A, Alzoman NZ, Almehizia AA, Darwish IA

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Amphiphilic Poly-<i>N</i>-vinylpyrrolidone Nanoparticles as Carriers for Nonsteroidal, Anti-Inflammatory Drugs: Pharmacokinetic, Anti-Inflammatory, and Ulcerogenic Activity Study by Andrey Kuskov, Dragana Nikitovic, Aikaterini Berdiaki, Mikhail Shtilman, Aristidis Tsatsakis

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A "middle‐out approach" for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models by Estelle Yau, Michael Gertz, Kayode Ogungbenro, Leon Aarons, Andrés Olivares‐Morales

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Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability by Dennison TJ, Smith JC, Badhan RK, Mohammed AR

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How to Achieve Sufficient Endogenous Insulin Suppression in Euglycemic Clamps Assessing the Pharmacokinetics and Pharmacodynamics of Long-Acting Insulin Preparations Employing Healthy Volunteers by Hui Liu, Ting Li, Hongling Yu, Jiaqi Li, Huiwen Tan, Yerong Yu

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Exploring pharmacokinetic variability of palbociclib in HR+/HER2- metastatic breast cancer: a focus on age, renal function, and drug-gene interactions by Elena Peruzzi, Bianca Posocco, Lorenzo Gerratana, Lorenzo Gerratana, Margherita Nuti, Marco Orleni, Marco Orleni, Sara Gagno, Elena De Mattia, Fabio Puglisi, Fabio Puglisi, Erika Cecchin, Giuseppe Toffoli, Rossana Roncato, Rossana Roncato

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