Search Results - "pharmacokinetics"

Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration by Beatrice Severino, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Giuseppe Caliendo, Vincenzo Santagada, Elisa Magli, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Natalícia J. Antunes, Julio Rojas-Moscoso, Noedi L. de Freitas, Gustavo D. Mendes, Gustavo D. Mendes, Gustavo D. Mendes, Gilberto De Nucci, Gilberto De Nucci, Gilberto De Nucci

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Pharmacokinetics and tissue distribution of four major bioactive components of Cynanchum auriculatum extract: a UPLC-MS/MS study in normal and functional dyspepsia rats by Jia Sun, Jia Sun, Xin Meng, Xin Meng, Di Huang, Di Huang, Zipeng Gong, Chunhua Liu, Ting Liu, Jie Pan, Yuan Lu, Lin Zheng

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Computational insight to design new potential hepatitis C virus NS5B polymerase inhibitors with drug-likeness and pharmacokinetic ADMET parameters predictions by Stephen Ejeh, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi

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Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict CYP3A-Mediated Drug Interaction between Saxagliptin and Nicardipine: Bridging Rat-to-Human Extrapolation by Jeong-Min Lee, Jin-Ha Yoon, Han-Joo Maeng, Yu Chul Kim

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Development of a novel intramuscular liposomal injection for advanced meloxicam delivery: Preparation, characterization, in vivo pharmacokinetics, pharmacodynamics, and pain assessment in an orthopedic pain model by Pierre A. Hanna, Hatim A. Al-Abbadi, Mohamed A. Hashem, Aziza E. Mostafa, Yasmina K. Mahmoud, Eman A. Ahmed, Ibrahim M. Hegab, Ibrahim E. Helal, Mahmoud F. Ahmed

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Pharmacokinetic Analysis of Huangqi Guizhi Wuwu Decoction on Blood and Brain Tissue in Rats with Normal and Cerebral Ischemia-Reperfusion Injury by Microdialysis with HPLC-MS/MS by Zheng HZ, Shen X, He YY, Yan XL, Wang SX, Yu AM, Wang LS

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Pharmacokinetic equivalence of CT‐P17 to high‐concentration (100 mg/ml) reference adalimumab: A randomized phase I study in healthy subjects by Kyung‐Sang Yu, In‐Jin Jang, Hyeong‐Seok Lim, Jang Hee Hong, Min‐Gul Kim, Min Kyu Park, Doo‐Yeoun Cho, Min Soo Park, Jae Yong Chung, Jong‐Lyul Ghim, SeungHwan Lee, Seok Kyu Yoon, In Sun Kwon, Sang Joon Lee, Sung Hyun Kim, Yun Ju Bae, Jung Bin Cha, Daniel E. Furst, Edward Keystone, Jonathan Kay

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Quantitative assessment of the relevance of organic-anion-transporting-polypeptide 1B1 and 2B1 polymorphisms in fexofenadine pharmacokinetic variants via pharmacometrics by Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee

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Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL‐6 levels following administration of the T‐cell bispecific engager glofitamab by Nassim Djebli, Neil Parrott, Felix Jaminion, Amaury O'Jeanson, Elena Guerini, David Carlile

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Pharmacokinetics of a Fixed-Dose Combination Product of Amlodipine, Losartan, Ezetimibe, and Rosuvastatin and Its Comparison with Co-administration of Four Individual Components in Healthy Participants by Jin-Woo Park, Hyewon Chung, Jong-Min Kim, Na Young Kim, Sung Hee Hong, Kyoung-Ah Kim, Ji-Young Park

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Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8 by Andreas Port, Jamie V. Shaw, Lena Klopp‐Schulze, Afrim Bytyqi, Claudia Vetter, Elizabeth Hussey, Nadra Mammasse, Victor Ona, Angelika Bachmann, Denis Strugala, Christian Reh, Kosalaram Goteti

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Safety, Pharmacokinetics, and Pharmacodynamics of a Single Bolus of the γ-aminobutyric Acid (GABA) Receptor Potentiator HSK3486 in Healthy Chinese Elderly and Non-elderly by Xiaojiao Li, Deming Yang, Qianqian Li, Hong Wang, Meng Wang, Pangke Yan, Nan Wu, Fangqiong Li, Shiping Ma, Yanhua Ding, Jingrui Liu, Hushan Wang

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Safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel acetylcholinesterase inhibitor: A phase I study in healthy young and elderly Chinese subjects by Hongjie Qian, Chengyin Yu, Huijuan Zhu, Qichen Ding, Yuting Cai, Jiao Jing, Xin Xu, Runcong Guo, Haiyan Zhang, Hong Liu, Xiaoyan Chen, Yun Liu

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The Association between <i>ABCG2</i> 421C>A (rs2231142) Polymorphism and Rosuvastatin Pharmacokinetics: A Systematic Review and Meta-Analysis by Yubin Song, Hee-Hyun Lim, Jeong Yee, Ha-Young Yoon, Hye-Sun Gwak

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Population Pharmacokinetic Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study by Seth K. Amponsah, PhD, George O. Adjei, MD, PhD, Christabel Enweronu-Laryea, MRCPCH, Kwasi A. Bugyei, PhD, Kosta Hadji-Popovski, MSc Pharm, Jorgen A.L. Kurtzhals, MD, PhD, Kim Kristensen, PhD

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Pharmacokinetics of single oral dose trazodone : a randomized, two-period, cross-over trial in healthy, adult, human volunteers under fed condition by PRASHANT eKALE, PRASHANT eKALE, Yadvendra eAgrawal

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A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects by Qian H, Chen Q, Liang L, Zou Y, Pu H, Xin L, Song R, Li T, Zhu H, Wang Y, Tian G, Shen J, Jiang H, Yu C, Wang Z, Jia J

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A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects by Park SI, Lee H, Oh J, Lim KS, Jang IJ, Kim JA, Jung JH, Yu KS

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Tailoring of Selenium-Plated Novasomes for Fine-Tuning Pharmacokinetic and Tumor Uptake of Quercetin: In Vitro Optimization and In Vivo Radiobiodistribution Assessment in Ehrlich Tumor-Bearing Mice by Heba M. Aboud, Amal K. Hussein, Abdallah Z. Zayan, Tarek Saad Makram, Mona O. Sarhan, Dina M. El-Sharawy

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Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin-Induced Nephrotic Syndrome Rat Models and Correlations With Efficacy and Hepatotoxicity by Wei Wu, Wei Wu, Rui Cheng, Rui Cheng, Hamza Boucetta, Hamza Boucetta, Lei Xu, Lei Xu, Jing-ru Pan, Jing-ru Pan, Min Song, Min Song, Yu-ting Lu, Yu-ting Lu, Tai-jun Hang, Tai-jun Hang

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