Search Results - "pharmacokinetics"

Comparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives and Their Blends with Mannitol/Lecithin Microparticles by Konstantina Manta, Paraskevi Papakyriakopoulou, Anna Nikolidaki, Evangelos Balafas, Nikolaos Kostomitsopoulos, Sabrina Banella, Gaia Colombo, Georgia Valsami

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Randomized, double‐blind, phase 1a single‐ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers by William K. Schmidt, Irene Cortés‐Puch, Cindy B. McReynolds, Glenn E. Croston, Sung Hee Hwang, Jun Yang, Theresa L. Pedersen, Karen M. Wagner, Theresa T. Pham, Thomas Hunt, Bruce D. Hammock

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Pharmacokinetic/Pharmacodynamic Target Attainment of Ceftazidime in Adult Patients on General Wards with Different Degrees of Renal Function: A Prospective Observational Bicenter Cohort Study by Saskia E. Zieck, Suzanne L. de Vroom, Frouke Ph. Mulder, Gitte van Twillert, Ron A. A. Mathôt, Suzanne E. Geerlings, Reinier M. van Hest

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Safety, pharmacokinetics, and pharmacodynamics of anti‐IL‐4Rα antibody SHR‐1819 in healthy subjects: A randomized, controlled phase I study by Na Li, Sepehr Shakib, Weilin Qian, Xiaoyan Yao, Puyuan Li, Tsz Keung Nip, Xiaoyan Bai, Kai Shen

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Comparative Pharmacokinetics of Sustained-Release versus Immediate-Release Melatonin Capsules in Fasting Healthy Adults: A Randomized, Open-Label, Cross-Over Study by Shefali Thanawala, R. Abiraamasundari, Rajat Shah

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The effect of multiple doses of ubrogepant on the pharmacokinetics of an oral contraceptive in healthy women: Results of an open-label, single-center, two-period, fixed-sequence study by Chi-Chung Li, John Palcza, Jialin Xu, Bob Thornton, Wendy Ankrom, Abhijeet Jakate, Eugene E Marcantonio

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A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody MK‐1654 in healthy Japanese adults by Yuji Orito, Naoyuki Otani, Yuki Matsumoto, Katsukuni Fujimoto, Nobuyuki Oshima, Brian M. Maas, Luzelena Caro, Antonios O. Aliprantis, Kara S. Cox, Osamu Tokumaru, Masaaki Kodama, Hideo Kudo, Hiromitsu Imai, Naoto Uemura

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Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Côte d'Ivoire. by Constant Edi, Catherine M Bjerum, Allassane F Ouattara, Yashpal S Chhonker, Louis K Penali, Aboulaye Méité, Benjamin G Koudou, Gary J Weil, Christopher L King, Daryl J Murry

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Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein by Zheng Yang, James Loy, Brian Poirson, Yanshan Dai, Surendran Rajendran, Shihua Xu, Vanessa Spires, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Krishna Vasudevan, Thomas Spires, Ruslan Novosiadly, Shodeinde Coker, Raymond Perez, Kelly Covello, Paul Morin, Robert Graziano, Miranda Broz, Lois Lehman-McKeeman

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Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats by Yoo-Seong Jeong, Anusha Balla, Kwang-Hoon Chun, Suk-Jae Chung, Han-Joo Maeng

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EFFECT OF GENES SLCO1B1 AND MDR1 POLYMORPHISM ON ATORVASTATIN PHARMACOKINETICS AND PHARMACODYNAMICS IN PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA: RESULTS OF PILOT PHARMACOGENETICS STUDY by A. V. Semenov, D. A. Sichev, V. G. Kukes

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In vivo Pharmacokinetic Drug-Drug Interaction Studies Between Fedratinib and Antifungal Agents Based on a Newly Developed and Validated UPLC/MS-MS Method by Congrong Tang, Xiaohui Niu, Lu Shi, Huidan Zhu, Guanyang Lin, Ren-ai Xu

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Retrospective Assessment of Translational Pharmacokinetic-Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor by Anita Moein, Jin Y. Jin, Matthew R. Wright, Bruno Alicke, Harvey Wong

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A phase I randomized, double‐blind, single subcutaneous dose escalation study to determine the safety, tolerability, and pharmacokinetics of rezafungin in healthy adult subjects by Kenan Gu, Dennis Ruff, Cassandra Key, Marissa Thompson, Shoshanna Jiang, Taylor Sandison, Shawn Flanagan

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Population pharmacokinetic model with time‐varying clearance for lorlatinib using pooled data from patients with non‐small cell lung cancer and healthy participants by Joseph Chen, Brett Houk, Yazdi K. Pithavala, Ana Ruiz‐Garcia

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Ranibizumab Port Delivery System in Neovascular Age-Related Macular Degeneration: Where Do We Stand? Overview of Pharmacokinetics, Clinical Results, and Future Directions by Matteo Mario Carlà, Maria Cristina Savastano, Francesco Boselli, Federico Giannuzzi, Stanislao Rizzo

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In vivo antimalarial effect of 1-hydroxy-5,6,7-trimethoxyxanthone isolated from Mammea siamensis T. Anders. flowers: pharmacokinetic and acute toxicity studies by Prapaporn Chaniad, Arnon Chukaew, Prasit Na-ek, Gorawit Yusakul, Litavadee Chuaboon, Arisara Phuwajaroanpong, Walaiporn Plirat, Atthaphon Konyanee, Abdi Wira Septama, Chuchard Punsawad

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The DECISIVE study: defining beta-lactam concentration in intensive care unit patients - the pharmacokinetics of piperacillin and meropenem in critically ill patients with conserved renal function by M. Abdul-Aziz, M. Rozali, M. Othman-Jailani, A. Abd Rahman, H. Sulaiman, N. Atiya, S. Adiraju, S. Wallis, W. Wan Mat, M. Mazlan, M. Jamaluddin, M. Hasan, M. Mat-Nor, J. Roberts

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A Physiologically Based Pharmacokinetic Model for Studying the Biowaiver Risk of Biopharmaceutics Classification System Class I Drugs With Rapid Elimination: Dexketoprofen Trometamol Case Study by Xian Zhang, Xuxiao Ye, Kuan Hu, Wenping Li, Wenqian Li, Qingqing Xiao, Lin Chen, Jin Yang

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The effect of itraconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics of the first‐in‐class ACKR3/CXCR7 antagonist, ACT‐1004‐1239 by Christine Huynh, Jasper Dingemanse, Henriette E. Meyer zu Schwabedissen, Marlene Fonseca, Patricia N. Sidharta

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