Search Results - "pharmacokinetics"

QSAR, ADMET In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Studies of Novel Bicyclo (Aryl Methyl) Benzamides as Potent GlyT1 Inhibitors for the Treatment of Schizophrenia by Mohamed El fadili, Mohammed Er-Rajy, Mohammed Kara, Amine Assouguem, Assia Belhassan, Amal Alotaibi, Nidal Naceiri Mrabti, Hafize Fidan, Riaz Ullah, Sezai Ercisli, Sara Zarougui, Menana Elhallaoui

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In Vitro and In Vivo Bioequivalence Study of 3D-Printed Instant-Dissolving Levetiracetam Tablets and Subsequent Personalized Dosing for Chinese Children Based on Physiological Pharmacokinetic Modeling by Xianfu Li, En Liang, Xiaoxuan Hong, Xiaolu Han, Conghui Li, Yuxi Wang, Zengming Wang, Aiping Zheng

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A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators by Yiting Yang, Zexin Zhang, Ping Li, Weimin Kong, Xiaodong Liu, Li Liu

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Optimization of 2-Aminoquinazolin-4-(3<i>H</i>)-one Derivatives as Potent Inhibitors of SARS-CoV-2: Improved Synthesis and Pharmacokinetic Properties by Young Sup Shin, Jun Young Lee, Sangeun Jeon, Jung-Eun Cho, Subeen Myung, Min Seong Jang, Seungtaek Kim, Jong Hwan Song, Hyoung Rae Kim, Hyeung-geun Park, Lak Shin Jeong, Chul Min Park

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Bictegravir Plus Tenofovir Alafenamide Nanoformulation as a Long-Acting Pre-Exposure Prophylaxis Regimen: Application of Modeling to Design Non-Human Primate Pharmacokinetic Experiments by Simone Perazzolo, Subhra Mandal, Pavan K. Prathipati, Christopher J. Destache

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LC-MS determination and pharmacokinetic study of salidroside in rat plasma after oral administration of suspensions of traditional Chinese medicine Erzhi Wan and Fructus Ligustri lucidi by Ze-Yun Li, Qing Li, Jiang Lü, Jun-Hong Ling, Xi-Hua Yu, Xiao-Hui Chen, Kai-Shun Bi

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Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry by Zhijun Wang, Bogdan Z. Olenyuk, Jean Chen Shih, Jeffrey Wang

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An exploratory first‐in‐man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2‐ and 1‐week interval in patients with metastatic castration resistant prostate cancer by Josephina P. M. Vrouwe, Ingrid M. C. Kamerling, Michiel J. vanEsdonk, Josbert M. Metselaar, Frederik E. Stuurman, Gabri van derPluijm, Jacobus Burggraaf, Susanne Osanto

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Development and Validation of an UPLC-MS/MS Method for Pharmacokinetic Comparison of Five Alkaloids from JinQi Jiangtang Tablets and Its Monarch Drug Coptidis Rhizoma by Lili Sun, Feifei Ding, Guangjiao You, Han Liu, Meng Wang, Xiaoliang Ren, Yanru Deng

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A population pharmacokinetic‐pharmacodynamic model of YH12852, a highly selective 5‐hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation by Siun Kim, Hyun A. Lee, Seong Bok Jang, Howard Lee

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Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab by Blaise Pasquiers, Salih Benamara, Mathieu Felices, David Ternant, Xavier Declèves, Alicja Puszkiel

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Interactions of selected cardiovascular active natural compounds with CXCR4 and CXCR7 receptors: a molecular docking, molecular dynamics, and pharmacokinetic/toxicity prediction study by Hussam Aly Sayed Murad, Thamer Mohammed Ahmed Alqurashi, Mostafa Aly Hussien

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A comprehensive evaluation in clinic and physiologically‐based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvir by Ziping Yang, Nathalie Rioux, Ludwig Vincent, Hannah M. Jones, David Cha, Andrew Plummer, David Wilfret, Brian P. Kearney

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Optimization of the Pharmacokinetic Profile of [^99mTc]Tc-N₄-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence by Thomas Günther, Matthias Konrad, León Stopper, Jan-Philip Kunert, Sebastian Fischer, Roswitha Beck, Angela Casini, Hans-Jürgen Wester

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Tolerability, safety, and pharmacokinetics of a single intravenous administration of a novel recombinant humanized anti-interleukin-6 receptor monoclonal antibody in healthy Chinese volunteers by Xin Jiang, Pingping Lin, Feifei Sun, Yi Xu, Ye Tao, Ping Shi, Yanping Liu, Xin Li, Shuqin Liu, Xiaomeng Gao, Chenjing Wang, Yu Cao

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Compritol-Based Nanostrucutured Lipid Carriers (NLCs) for Augmentation of Zolmitriptan Bioavailability via the Transdermal Route: In Vitro Optimization, Ex Vivo Permeation, In Vivo Pharmacokinetic Study by Doaa H. Hassan, Joseph N. Shohdy, Doaa Ahmed El-Setouhy, Mohamed El-Nabarawi, Marianne J. Naguib

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Physiologically‐Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam by Hannah Britz, Nina Hanke, Anke‐Katrin Volz, Olav Spigset, Matthias Schwab, Thomas Eissing, Thomas Wendl, Sebastian Frechen, Thorsten Lehr

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Simultaneous Determination of A Novel Antitrypanosomal Compound (OSU-36) and its Ester Derivative (OSU-40) in Plasma by HPLC: Application to First Pharmacokinetic Study in Rats by Pavel Gershkovich, Kishor M. Wasan, Olena Sivak, Summer Lysakowski, Carolyn Reid, Kokku Premalatha, Karl A. Werbovetz

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Pharmacokinetics and safety profiles of beinaglutide injection, a recombinant human GLP-1, in adults with overweight/obesity: results from a phase I clinical trial by Pingping Lin, Chengqian Li, Yanping Liu, Feifei Sun, Tsung-Han Hsieh, Lin Zhang, Yaping Ma, Xiaomeng Gao, Qing Yu, Yu Cao

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The effect of OCT-2 inhibitor Daclatasvir on Metformin pharmacokinetics and pharmacodynamics at two dose levels: A Bayesian approach using Markov-Chain Monte Carlo simulations by Mohamed Raslan, Lamia Elwakeel, Sara Shahin

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