Search Results - "pharmacokinetics"

Assessing antiretroviral drug (ARV) bioavailability in HIV tissue reservoirs using in vitro and in vivo pharmacokinetic (PK) studies with human primary lymphoid endothelial cells and mice by S. Dyavar, A. Podany, N. Gautam, Y. Alnouti, C. Fletcher, L. Winchester, T. Mykris, J. Weinhold, K. Campbell

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Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy by Paola Coppola, Andrew Butler, Susan Cole, Essam Kerwash

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Impact of Subacute Exposure to T-2 Toxin and Zearalenone on the Pharmacokinetics of Midazolam as CYP3A Probe Drug in a Porcine Animal Model: A Pilot Study by Wim Schelstraete, Mathias Devreese, Siska Croubels

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First-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of Hepenofovir, a Novel Hepatic Targeting Prodrug of Tenofovir in Healthy Chinese Subjects by Hong Zhang, Lei Gao, Jinfeng Lou, Min Wu, Hong Chen, Lizhi Yang, Jingrui Liu, Xiaoxue Zhu, Xiaojiao Li, Cuiyun Li, Meng Wang, Chengjiao Liu, Weibo Guo, Yuan Wang, Zhongqiang Gao, Lei Han, Daidi Wang, Weili Jin, Yanhua Ding

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of aficamten in healthy Chinese participants: a randomized, double-blind, placebo-controlled, phase 1 study by Xue Zhao, Hongzhong Liu, Wei Tian, Ligang Fang, Mengyang Yu, Xiaofei Wu, Aijing Liu, Ruijie Wan, Li Li, Jinghui Luo, Yuqiong Li, Bo Liu, Yu He, Xiaowen Chen, Yuan Li, Donghong Xu, Hongyun Wang, Xiaohong Han

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Pharmacokinetics and Pharmacodynamics Estimation of Eculizumab in a 2-Year-Old Girl With Atypical Hemolytic Uremic Syndrome: A Case Report With 4-Year Follow-Up by Ken Saida, Tsuyoshi Fukuda, Kana Mizuno, Masao Ogura, Koichi Kamei, Shuichi Ito

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The Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Pinostrobin in Rats: Ultra-High-Performance Liquid Chromatography Coupled With Linear Trap Quadrupole Orbitrap Mass Spectrometry Studies by Xiaoya Sun, Xiaoya Sun, Xiaojun Liu, Suiqing Chen, Suiqing Chen

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Development and validation of a UPLC-MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics by Gang Wang, Dongyang Zhao, Hongxiang Chen, Dawei Ding, Longfa Kou, Lifang Sun, Chenxia Hao, Xincong Li, Kai Jia, Qiming Kan, Xiaohong Liu, Zhonggui He, Jin Sun

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Population Pharmacokinetic (Pop-PK) Analysis of Torsemide in Healthy Korean Males Considering CYP2C9 and OATP1B1 Genetic Polymorphisms by Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee

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Interaction Between Sex and Organic Anion‐Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib‐N‐Oxide and Regorafenib‐Glucuronide in Mice by Qiang Fu, Mingqing Chen, Jason T. Anderson, Xinxin Sun, Shuiying Hu, Alex Sparreboom, Sharyn D. Baker

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Pharmacokinetic Comparison Between a Fixed-Dose Combination of Atorvastatin/Omega-3-Acid Ethyl Esters and the Corresponding Loose Combination in Healthy Korean Male Subjects by Khwarg J, Lee S, Jang IJ, Kang WH, Lee HJ, Kim KY, Jeong KS, Won C, Choi YW, Ha DC, Jung R, Han MG, Jung WT, Nam KY, Kim YS, Yu KS, Oh J

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Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects by Mark Forman, John Palcza, Jack Tseng, Julie A. Stone, Brittany Walker, Dennis Swearingen, Matthew D. Troyer, Marissa F. Dockendorf

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Natural Product Ginsenoside 20(S)-25-Methoxyl-Dammarane-3β, 12β, 20-Triol in Cancer Treatment: A Review of the Pharmacological Mechanisms and Pharmacokinetics by Dohyun Kim, Minwoo Park, Iqra Haleem, Younghong Lee, Jain Koo, Young Chae Na, Gidong Song, Jaehwi Lee

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Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety by Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, Chang Hyun Oh

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Fabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation by Diana E. Aziz, Aly A. Abdelbary, Abdelhalim I. Elassasy

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Comparative Pharmacokinetics of Sulfadiazine and Its Metabolite N4-Acetyl Sulfadiazine in Grass Carp (<i>Ctenopharyngodon idella</i>) at Different Temperatures after Oral Administration by Ning Xu, Miao Li, Zhoumeng Lin, Xiaohui Ai

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Adapting regulatory drug‐drug interaction guidance to design clinical pharmacokinetic natural product‐drug interaction studies: A NaPDI Center recommended approach by Emily J. Cox, Allan E. Rettie, Jashvant D. Unadkat, Kenneth E. Thummel, Jeannine S. McCune, Mary F. Paine

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Tolerability, Safety, Pharmacokinetics and Drug Interaction of Cefotaxime Sodium-Tazobactam Sodium Injection (6:1) Following Single and Multiple Intravenous Doses in Chinese Healthy Subjects by Ning Chen, Ning Chen, Lu-Ning Sun, Wen-Hui Hu, Yi-Ya Wang, Li-Jun Xie, Juan Cheng, Hong-Wen Zhang, Yun Liu, Yong-Qing Wang, Li Ding

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Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing by Fawaz Alasmari, Mohammed S. Alasmari, Hussa Mubarak Muwainea, Hatun A. Alomar, Abdullah F. Alasmari, Sary Alsanea, Aws Alshamsan, Muhammad F. Rasool, Faleh Alqahtani

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A double blind clinical trial evaluating the relative pharmacokinetics and bioavailability of oral creatine monohydrate when combined with either isomaltulose or dextrose in healthy adult males by Kalman Douglas S, Feldman Samantha, Schwartz Howard I, Krieger Diane R

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