Search Results - "pharmacokinetics"

A pharmacokinetic drug-drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV‐2 (COVID‐19) DHODH (dihydroorotate dehydrogenase) inhibitor by Terri L. Morton, Oscar L. Laskin, Diksha Kaushik, Lucy Lee, Jiyuan Ma, Allan Kristensen, Kylie O'Keefe, Lee Golden, Matthew Klein, Ronald Kong

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Effect of Pomelo Juice on the Pharmacokinetics of Simvastatin, CYP3A2 Activity and Mdr1a, Mdr1b and Slc21a5 Expressions in Rats by Kritsakorn Rayasilp, Piyanuch Wonganan, Pajaree Chariyavilaskul, Nuntaporn Prompila, Varumporn Sukkummee, Supeecha Wittayalertpanya

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Shedding a Light on Acyclovir Pharmacodynamics: A Retrospective Analysis on Pharmacokinetic/Pharmacodynamic Modelling of Acyclovir for the Treatment of Varicella Zoster Virus Infection in Immunocompromised Patients: A Pilot Study by Geeske F. Grit, Anne-Grete Märtson, Marjolein Knoester, Marlous L. Toren-Wielema, Daan J. Touw

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial by Yu-zhou Gui, Yu-zhou Gui, Wei Wang, Wei Wang, Qing-qing Wu, Qing-qing Wu, Qi-chen Ding, Qi-chen Ding, Hong-jie Qian, Hong-jie Qian, Qiu-bei Lu, Ying-jun Zhang, Yu-lei Zhuang, Li Deng, Ying-lin Zuo, Lin Luo, Jing-ying Jia, Jing-ying Jia

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Development and In Vitro Evaluation of Controlled Release Viagra^® Containing Poloxamer-188 Using Gastroplus^™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments by Mosab Arafat, Muhammad Sarfraz, Salahdein AbuRuz

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Quantification of 1D, a novel derivative of curcumin with potential antitumor activity, in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study in rats by Jialin Sun, Tao Jiang, Wen Xu, Zhangying Feng, Xianghua Quan, Ping Leng, Wei Sun, Jun Zhao, Fanbo Jing, Jing Li

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Aniline Derivatives Containing 1-Substituted 1,2,3-Triazole System as Potential Drug Candidates: Pharmacokinetic Profile Prediction, Lipophilicity Analysis Using Experimental and In Silico Studies by Elwira Chrobak, Katarzyna Bober-Majnusz, Mirosław Wyszomirski, Andrzej Zięba

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In silico evaluation of some 4-(quinolin-2-yl)pyrimidin-2-amine derivatives as potent V600E-BRAF inhibitors with pharmacokinetics ADMET and drug-likeness predictions by Abdullahi Bello Umar, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba

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Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4, P‐gp, and CYP2D6 drug-drug-gene interaction network by Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, Sebastian Frechen, Maaike van derLee, Dirk Jan A. R. Moes, Jesse J. Swen, Matthias Schwab, Thorsten Lehr

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Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes by Alinafe Magret Kapelemera, Yow-Shieng Uang, Yow-Shieng Uang, Li-Hsuan Wang, Tien-Yuan Wu, Fang-Yu Lee, Li Tai, Ching-Chiung Wang, Ching-Chiung Wang, Ching-Chiung Wang, Ching-Chiung Wang, Chia-Jung Lee, Chia-Jung Lee, Chia-Jung Lee

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Evaluation of the pharmacokinetics, dosimetry, and therapeutic efficacy for the α-particle-emitting transarterial radioembolization (αTARE) agent [225Ac]Ac-DOTA-TDA-Lipiodol® against hepatic tumors by Anders Josefsson, Angel G. Cortez, Harikrishnan Rajkumar, Joseph D. Latoche, Ambika P. Jaswal, Kathryn E. Day, Mohammadreza Zarisfi, Lora H. Rigatti, Ziyu Huang, Jessie R. Nedrow

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Target-mediated pharmacokinetic/pharmacodynamic model based meta-analysis and dosing regimen optimization of a long-acting release formulation of exenatide in patients with type 2 diabetes mellitus by Hanqing Li, Jiayin Xu, Xiaohong Fan

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Bioanalytical LC-QTOF/MS Method for a <i>N</i>-phenylpiperazine Derivate (LQFM05): An Anxiolytic- and Antidepressant-like Prototype Drug Applied to Pharmacokinetic and Biodistribution Studies by Ana Cláudia M. Ramos, Kênnia R. Rezende, Carolina M. Teixeira, Aline R. Fernandes, Heloa Santos, Rúbia Darc Machado, Ricardo Menegatti, Boniek G. Vaz, Andréa R. Chaves

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Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction by Ryuta Asaumi, Karsten Menzel, Wooin Lee, Ken‐ichi Nunoya, Haruo Imawaka, Hiroyuki Kusuhara, Yuichi Sugiyama

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Is the current therapeutic dosage of nadroparin adequate for neonates and infants under 8 months with thromboembolic disease? a population pharmacokinetic study from a national children's medical center by Yewei Chen, Jianger Lan, Lin Zhu, Min Dong, Min Dong, Yi Wang, Zhiping Li

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A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model by Songmao Zheng, Jin Niu, Brian Geist, Damien Fink, Zhenhua Xu, Honghui Zhou, Weirong Wang

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Pharmacokinetics of gallic acid and protocatechuic acid in humans after dosing with Relinqing (RLQ) and the potential for RLQ-perpetrated drug-drug interactions on organic anion transporter (OAT) 1/3 by Ziqiang Li, Xi Du, Yanfen Li, Ruihua Wang, Changxiao Liu, Yanguang Cao, Weidang Wu, Jinxia Sun, Baohe Wang, Yuhong Huang

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Repurposing Treatment of Wernicke-Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile by Vatsalya Vatsalya, Vatsalya Vatsalya, Fengyuan Li, Fengyuan Li, Jane Frimodig, Jane Frimodig, Khushboo S. Gala, Shweta Srivastava, Shweta Srivastava, Maiying Kong, Maiying Kong, Vijay A. Ramchandani, Wenke Feng, Wenke Feng, Wenke Feng, Wenke Feng, Xiang Zhang, Xiang Zhang, Xiang Zhang, Xiang Zhang, Xiang Zhang, Craig J. McClain, Craig J. McClain, Craig J. McClain, Craig J. McClain, Craig J. McClain

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Improved Pharmacokinetic Feasibilities of Mirabegron-1,2-Ethanedisulfonic Acid, Mirabegron-1,5-Naphthalenedisulfonic Acid, and Mirabegron-L-Pyroglutamic Acid as Co-Amorphous Dispersions in Rats and Mice by Seo-Yeon Kim, Byung Hoon You, Mingoo Bae, Seung Yon Han, Kiwon Jung, Young Hee Choi

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Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model by Maryna Perepelyuk, Chellappagounder Thangavel, Yi Liu, Robert B Den, Bo Lu, Adam E Snook, Sunday A Shoyele

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