Search Results - "pharmacokinetics"

Population Pharmacokinetic Modeling for Twice-Daily Intravenous Busulfan in a Large Cohort of Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation-A 10-Year Single-Center Experience by Katharina M. Schreib, Dominic S. Bräm, Ulrike Barbara Zeilhofer, Daniel Müller, Tayfun Güngör, Stefanie D. Krämer, Mathias M. Hauri-Hohl

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Pharmacokinetic Characterization and Comparative Bioavailability of an Innovative Orodispersible Fixed-Dose Combination of Ivermectin and Albendazole: A Single Dose, Open Label, Sequence Randomized, Crossover Clinical Trial in Healthy Volunteers by Jaime Algorta, Alejandro Krolewiecki, Alejandro Krolewiecki, Filipe Pinto, Silvia Gold, Jose Muñoz

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The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations by Qianting Yang, Tao Zhang, Ying Zhang, Dan Sun, Dan Sun, Xiaowei Zheng, Xiaowei Zheng, Qian Du, Xue Wang, Xue Wang, Xiaoliang Cheng, Jianfeng Xing, Jianfeng Xing, Yalin Dong

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Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu‐like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll‐like receptor 7 agonist ruzotolimod by Qiudi Jiang, Yuchen Zhang, Dan Duan, Sylvie Retout, Ruchi Upmanyu, Katerina Glavini, Miriam Triyatni, Yonghong Zhu, Joseph F. Grippo, Yuyan Jin

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Dose-proportional pharmacokinetic properties of GLA5PR GLARS-NF1 controlled-release pregabalin in healthy Korean volunteers: a randomized, open, single-dose, parallel study by Shin KH, Jeon JY, Jang K, Kim TE, Kim MG

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Pharmacokinetics and Bioequivalence of Two Formulations of Valsartan 80 mg Capsules: A Randomized, Single Dose, 4-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions by Wu Q, Wang X, Chen Q, Zou Y, Xu X, Li T, Yu C, Zhu F, Zhang KE, Jia J, Liu Y

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Comparison of Pharmacokinetic, Pharmacodynamic and Tolerability Profiles of CKD-11101, Darbepoetin Alfa (NESP®) Biosimilar, to Those of NESP® After a Single Subcutaneous or Intravenous Administration to Healthy Subjects by Jeon I, Oh J, Kwon YK, Yoon SH, Cho JY, Jang IJ, Yu KS, Lee S

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A Physiologically-Based Pharmacokinetic Model of Ruxolitinib and Posaconazole to Predict CYP3A4-Mediated Drug-Drug Interaction Frequently Observed in Graft versus Host Disease Patients by Bettina Gerner, Fatemeh Aghai-Trommeschlaeger, Sabrina Kraus, Götz Ulrich Grigoleit, Sebastian Zimmermann, Max Kurlbaum, Hartwig Klinker, Nora Isberner, Oliver Scherf-Clavel

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Effects of 1α,25-Dihydroxyvitamin D₃ on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach by Anusha Balla, Yoo-Seong Jeong, Hyo-Jung Kim, Yun-Jong Lee, Suk-Jae Chung, Yoon-Jee Chae, Han-Joo Maeng

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Variants in <i>COMT</i>, <i>CYP3A5</i>, <i>CYP2B6,</i> and <i>ABCG2</i> Alter Quetiapine Pharmacokinetics by Pablo Zubiaur, Paula Fernández-Campos, Marcos Navares-Gómez, Paula Soria-Chacartegui, Gonzalo Villapalos-García, Manuel Román, Gina Mejía-Abril, Dolores Ochoa, Francisco Abad-Santos

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Validation of an LC-MS/MS Method to Quantify the New TRPC6 Inhibitor SH045 (Larixyl <i>N</i>-methylcarbamate) and Its Application in an Exploratory Pharmacokinetic Study in Mice by Xiao-Ning Chai, Friedrich-Alexander Ludwig, Anne Müglitz, Michael Schaefer, Hai-Yan Yin, Peter Brust, Ralf Regenthal, Ute Krügel

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Simultaneous Determination of Procainamide and N-acetylprocainamide in Rat Plasma by Ultra-High-Pressure Liquid Chromatography Coupled with a Diode Array Detector and Its Application to a Pharmacokinetic Study in Rats by Anusha Balla, Kwan Hyung Cho, Yu Chul Kim, Han-Joo Maeng

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Evaluation of drug‐drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a physiologically‐based pharmacokinetic model by Ashit Trivedi, Winnie Sohn, Priyanka Kulkarni, Pegah Jafarinasabian, Hanze Zhang, Marintan Spring, Stephen Flach, Siddique Abbasi, Jan Wahlstrom, Edward Lee, Sandeep Dutta

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A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson&rsquo;s disease, in healthy volunteers by Shin W, Lim KS, Kim MK, Kim HS, Hong J, Jhee S, Kim J, Yoo S, Chung YT, Lee JM, Cho DY

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Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients by Johannes Matthaei, Jürgen Brockmöller, Werner Steimer, Konstanze Pischa, Stefan Leucht, Maria Kullmann, Ole Jensen, Typhaine Ouethy, Mladen Vassilev Tzvetkov, Mladen Vassilev Tzvetkov, Muhammad Rafehi

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Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model by Hans-Soenke Jans, Xiao-Hong Yang, Dion R Brocks, Piyush Kumar, Melinda Wuest, Leonard I Wiebe

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Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations by Sabina Mugusi, Sabina Mugusi, Abiy Habtewold, Eliford Ngaimisi, Wondwossen Amogne, Getnet Yimer, Omary Minzi, Eyasu Makonnen, Eyasu Makonnen, Christopher Sudfeld, Jürgen Burhenne, Eleni Aklillu

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Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on "De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling" by Karel Allegaert, Anne Smits, Pieter Annaert

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Scaling Approaches for Pediatric Dose Selection: The Fremanezumab (AJOVY^®) Journey to Select a Phase 3 Dose Using Pharmacokinetic Data from a Phase 1 Study by Aksana Jones, Orit Cohen-Barak, Andrijana Radivojevic, Jill Fiedler-Kelly

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Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized <i>Centella asiatica</i> Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial by Kirsten M. Wright, Melissa Bollen, Jason David, Alex B. Speers, Mikah S. Brandes, Nora E. Gray, Armando Alcázar Magaña, Christine McClure, Jan F. Stevens, Claudia S. Maier, Joseph F. Quinn, Amala Soumyanath

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