Search Results - "pharmacokinetics"

A simple HPLC-MS/MS method for the determination of polymyxin B in human plasma and its application in the pharmacokinetic study in elderly patients infected with multidrug-resistant Gram-negative bacteria by Sheng Hu, Sheng Hu, Nan Guo, Juan Zeng, Yue Li, Yahui Zhang, Jinjiao Jiang, Bing Leng, Chengwu Shen

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Does Cytokine-Release Syndrome Induced by CAR T-Cell Treatment Have an Impact on the Pharmacokinetics of Meropenem and Piperacillin/Tazobactam in Patients with Hematological Malignancies?... by Chun Liu, Pier Giorgio Cojutti, Maddalena Giannella, Marcello Roberto, Beatrice Casadei, Gianluca Cristiano, Cristina Papayannidis, Nicola Vianelli, Pier Luigi Zinzani, Pierluigi Viale, Francesca Bonifazi, Federico Pea

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A phase 1, randomized, double‐blind, placebo‐controlled study to evaluate the safety, tolerability, and pharmacokinetics of single and multiple doses of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adult subjects by James Ermer, Patrick Martin, Mary Corcoran, Yumiko Matsuo

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Saliva as a noninvasive sampling matrix for therapeutic drug monitoring of intravenous busulfan in Chinese patients undergoing hematopoietic stem cell transplantation: A prospective population pharmacokinetic and simulation study by Baohua Xu, Ting Yang, Jianxing Zhou, You Zheng, Jingting Wang, Qingxia Liu, Dandan Li, Yifan Zhang, Maobai Liu, Xuemei Wu

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Molecular Docking, Drug-Likeness Analysis, In Silico Pharmacokinetics, and Toxicity Studies of p-Nitrophenyl Hydrazones as Anti-inflammatory Compounds against COX-2, 5-LOX, and H+/K+ ATPase by Sodeeq Babalola, Nosakhare Igie, Isaiah Odeyemi

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In Silico Pharmacokinetic Profiling of the Identified Bioactive Metabolites of <i>Pergularia tomentosa</i> L.... by Amr S. Abouzied, Marwa M. Abd-Rabo, Bader Huwaimel, Suliman A. Almahmoud, Afnan Abdulkareem Almarshdi, Fai Mutaz Alharbi, Sulafa Salem Alenzi, Bayan Naef Albsher, Ahmed Alafnan

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An exploratory, randomized, parallel-group, open-label, relative bioavailability study with an additional two-period crossover food-effect study exploring the pharmacokinetics of two novel formulations of pexmetinib (ARRY-614) by Wollenberg LA, Corson DT, Nugent CA, Peterson FL, Ptaszynski AM, Arrigo A, Mannila CG, Litwiler KS, Bell SJ

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Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole&#x2011;Induced Drug&ndash;Drug Interaction by Zhang Y, Zhang J, Xu Q, Wang Y, Wu W, Wang W, Li X, Zhang T

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Pharmacokinetic and Pharmacodynamic Comparison of Two Formulations of a Fixed-Dose Combination of Gemigliptin/Rosuvastatin 50/20 mg: A Randomized, Open-Label, Single-Dose, Two-Way Crossover Study by Yang E, Yoo H, Jang IJ, Yu KS, Lee S

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Investigation of the Effect on the Albumin Binding Moiety for the Pharmacokinetic Properties of ⁶⁸Ga-, ^205/206Bi-, and ¹⁷⁷Lu-Labeled NAPamide-Based Radiopharmaceuticals by Dániel Szücs, Judit P. Szabó, Viktória Arató, Barbara Gyuricza, Dezső Szikra, Imre Tóth, Zita Képes, György Trencsényi, Anikó Fekete

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Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo by Nadine Holzleitner, Thomas Günther, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester

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Development of a Pharmacokinetic Model Describing Neonatal Fc Receptor‐Mediated Recycling of HL2351, a Novel Hybrid Fc‐Fused Interleukin‐1 Receptor Antagonist, to Optimize Dosage Regimen by Lien Ngo, Jaeseong Oh, Anhye Kim, Hyun‐moon Back, Won‐ho Kang, Jung‐woo Chae, Hwi‐yeol Yun, Howard Lee

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A Phase 1, randomized, open-label crossover study to evaluate the safety and pharmacokinetics of 400 mg albaconazole administered to healthy participants as a tablet formulation versus a capsule formulation by van Rossem K, Lowe JA

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Comparison of the pharmacokinetics and tolerability of HCP1004 (a fixed-dose combination of naproxen and esomeprazole strontium) and VIMOVO&reg; (a marketed fixed-dose combination of naproxen and esomeprazole magnesium) in healthy volunteers by Choi YJ, Han HK, Shin D, Lim KS, Yu KS

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SeDeM expert system with I-optimal mixture design for oral multiparticulate drug delivery: An encapsulated floating minitablets of loxoprofen Na and its in silico physiologically based pharmacokinetic modeling by Rauf-, Muhammad Harris Shoaib, Farrukh Rafiq Ahmed, Rabia Ismail Yousuf, Fahad Siddiqui, Muhammad Talha Saleem, Faaiza Qazi, Momina Zarish Khan, Asma Irshad, Lubna Bashir, Shazia Naz, Muhammad Farooq, Zafar Alam Mahmood

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Pharmacokinetic/Pharmacodynamic Analysis and Dose Optimization of Cefmetazole and Flomoxef against Extended-Spectrum β-Lactamase-Producing <i>Enterobacterales</i> in Patients with Invasive Urinary Tract Infection Considering Renal Function by Yukihiro Hamada, Hidefumi Kasai, Moeko Suzuki-Ito, Yasufumi Matsumura, Yohei Doi, Kayoko Hayakawa

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Effects of CYP3A4 and P-glycoprotein inhibition or induction on the pharmacokinetics of ubrogepant in healthy adults: Two phase 1, open-label, fixed-sequence, single-center, crossover trials by Abhijeet Jakate, Ramesh Boinpally, Matthew Butler, Wendy Ankrom, Marissa F Dockendorf, Antonia Periclou

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Pharmacokinetics, safety, and immunogenicity of HLX03, an adalimumab biosimilar, compared with reference biologic in healthy Chinese male volunteers: Results of a randomized, double‐blind, parallel‐controlled, phase 1 study by Hong Zhang, Min Wu, Jixuan Sun, Xiaoxue Zhu, Cuiyun Li, Yanhua Ding, Xiaodi Zhang, Katherine Chai, Xiaojiao Li

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A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors by Michael W. Bishop, Paul R. Hutson, Jacquelyn A. Hank, Paul M. Sondel, Wayne L. Furman, Michael M. Meagher, Fariba Navid, Victor M. Santana

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Impact of Maximizing Css/MIC Ratio on Efficacy of Continuous Infusion Meropenem Against Documented Gram-Negative Infections in Critically Ill Patients and Population Pharmacokinetic/Pharmacodynamic Analysis to Support Treatment Optimization by Pier Giorgio Cojutti, Milo Gatti, Milo Gatti, Matteo Rinaldi, Matteo Rinaldi, Tommaso Tonetti, Tommaso Tonetti, Cristiana Laici, Chiara Mega, Chiara Mega, Antonio Siniscalchi, Maddalena Giannella, Maddalena Giannella, Pierluigi Viale, Pierluigi Viale, Federico Pea, Federico Pea

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