Search Results - "pharmacokinetics"

<i>CYP3A5*3</i> and <i>CYP3A4*22</i> Cluster Polymorphism Effects on LCP-Tac Tacrolimus Exposure: Population Pharmacokinetic Approach by Zeyar Mohammed Ali, Marinda Meertens, Beatriz Fernández, Pere Fontova, Anna Vidal-Alabró, Raul Rigo-Bonnin, Edoardo Melilli, Josep M. Cruzado, Josep M. Grinyó, Helena Colom, Nuria Lloberas

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Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.)... by Kirsten M. Wright, Kirsten M. Wright, Melissa Bollen, Melissa Bollen, Jason David, Bridgette Mepham, Armando Alcázar Magaña, Armando Alcázar Magaña, Christine McClure, Claudia S. Maier, Claudia S. Maier, Joseph F. Quinn, Joseph F. Quinn, Joseph F. Quinn, Amala Soumyanath, Amala Soumyanath

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No Relevant Pharmacokinetic Drug&ndash;Drug Interaction Between the Sodium-Glucose Co-Transporter-2 Inhibitor Empagliflozin and Lobeglitazone, a Peroxisome Proliferator-Activated Receptor-&gamma; Agonist, in Healthy Subjects by Kim YK, Hwang JG, Park MK

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Pharmacokinetic Bioequivalence and Safety Assessment of Two Venlafaxine Hydrochloride Extended-Release Capsules in Healthy Chinese Subjects Under Fed Conditions: A Randomized, Open-Label, Single-Dose, Crossover Study by Yingxia He, Jie Wang, Fang Yao, Pan Lu, Yafang Xie, Xiuwen Li, Qiangwei Liu, Yang Liu, Dan Cao, Jun Liang, Dan Tian, Guan Liu

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Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3&beta;, 12&beta;, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats by Zhang X, Zhang Y, Guo S, Bai F, Wu T, Zhao Y

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Safety, efficacy and pharmacokinetics of palivizumab in off-label neonates, infants, and young children at risk for serious respiratory syncytial virus infection: a multicenter phase II clinical trialResearch in context by Masaaki Mori, Kanako Yoshizaki, Shinichi Watabe, Mika Ishige, Akinari Hinoki, Takuya Kondo, Tomoaki Taguchi, Hisaya Hasegawa, Tomoko Hatata, Naoyuki Tanuma, Kosuke Kirino, Akihiro Hirakawa, Takuya Naruto, Minoru Imai, Ryuji Koike, Kenichiro Hosoi, Satoshi Kusuda

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Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development by Bonifazi, Donato

Subjects: “…human development research, paediatric drug discovery, preclinical research, juvenile animal models, paediatric pharmacology, paediatric biomarkers, age-appropriate formulations, perinatal pharmacology, physiologically-based pharmacokinetic (PBPK)…”
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DOAB: description of the publication

Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development by Bonifazi, Donato

Subjects: “…human development research, paediatric drug discovery, preclinical research, juvenile animal models, paediatric pharmacology, paediatric biomarkers, age-appropriate formulations, perinatal pharmacology, physiologically-based pharmacokinetic (PBPK)…”
OAPEN Library: download the publication
OAPEN Library: description of the publication

Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?... by Thakkar D, Dash RP

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A Proof of Concept of the Usefulness of a TDM-Guided Strategy for Optimizing Pharmacokinetic/Pharmacodynamic Target of Continuous Infusion Ampicillin-Based Regimens in a Case Series of Patients with Enterococcal Bloodstream Infections and/or Endocarditis by Milo Gatti, Sara Tedeschi, Filippo Trapani, Stefania Ramirez, Rita Mancini, Maddalena Giannella, Pierluigi Viale, Federico Pea

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Evaluation of the Pharmacokinetics of Trazpiroben (TAK-906), a Peripherally Selective D2/D3 Dopamine Receptor Antagonist, in the Presence and Absence of Itraconazole, a Potent CYP 3A4 Inhibitor by Chen C, Zhang W, Bari M, Almansa C, Baratta M, Rosario M

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First-In-Human Results on the Biodistribution, Pharmacokinetics, and Dosimetry of [¹⁷⁷Lu]Lu-DOTA.SA.FAPi and [¹⁷⁷Lu]Lu-DOTAGA.... by Sanjana Ballal, Madhav Prasad Yadav, Euy Sung Moon, Vasko S Kramer, Frank Roesch, Samta Kumari, Chandrasekhar Bal

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Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin by Ravindranath R Gilibili, Ravi Kanth Bhamidipati, Ramesh Mullangi, Nuggehally R Srinivas

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Population Pharmacokinetic Model of Linezolid and Probability of Target Attainment in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation-A Step toward Correct Dosing by Dragana Milaković, Tijana Kovačević, Pedja Kovačević, Vedrana Barišić, Sanja Avram, Saša Dragić, Biljana Zlojutro, Danica Momčičević, Branislava Miljković, Katarina Vučićević

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Exome Sequence Data of Eight SLC Transporters Reveal That <i>SLC22A1</i> and <i>SLC22A3</i> Variants Alter Metformin Pharmacokinetics and Glycemic Control by Monserrat I. Morales-Rivera, Radamés Alemón-Medina, Angélica Martínez-Hernández, Cecilia Contreras-Cubas, Nelly F. Altamirano-Bustamante, Josefina Gómez-Garduño, Elvia C. Mendoza-Caamal, J. Orlando Nuñez-González, Raquel García-Álvarez, Cristina Revilla-Monsalve, José Antonio Valcarcel-Gamiño, José Rafael Villafan-Bernal, Federico Centeno-Cruz, Humberto García-Ortiz, Francisco Barajas-Olmos, Lorena Orozco

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Assessing the relative contribution of CYP3A-and P-gp-mediated pathways to the overall disposition and drug-drug interaction of dabigatran etexilate using a comprehensive mechanistic physiological-based pharmacokinetic model by Udomsak Udomnilobol, Wilasinee Dunkoksung, Watchara Sakares, Suree Jianmongkol, Thomayant Prueksaritanont

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A Rapid and Sensitive HPLC Method for Quantitation of Paclitaxel in Biological Samples using Liquid-Liquid Extraction and UV Detection: Application to Pharmacokinetics and Tissues Distribution Study of Paclitaxel Loaded Targeted Polymeric Micelles in..... by Mahboubeh Rezazadeh, Jaber Emami, Abolfazl Mostafavi, Mahboubeh Rostami, Farshid Hassanzadeh, Hojjat Sadeghi, Mohsen Minaiyan, Afsaneh Lavasanifar

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Farmacocinética e enantiosseletividade da bupivacaína em gestantes normais submetidas à anestesia epidural Pharmacokinetic and stereoselectivity of bupivacaine in normal pregnant women who were submitted to epidural anesthesia for cesarean section by Luciana de Barros Duarte

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Mass balance, metabolism, and pharmacokinetics of [14C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers by Chun-Yang Zhao, Chun-Yang Zhao, Li-Jun Zhang, Li-Jun Zhang, Chan Sun, Chan Sun, Cheng-Yin Yu, Cheng-Yin Yu, Cheng-Yin Yu, Jian Wang, Yang Sai, Wei-Guo Su, Qian Chen, Qian Chen, Wei Wang, Wei Wang, Jing-Ying Jia, Jing-Ying Jia, Gang-Yi Liu, Gang-Yi Liu, Yan-Mei Liu, Yan-Mei Liu

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Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies by Rajbharan Yadav, Siddharth Sukumaran, Tanja S. Zabka, Jinze Li, Amy Oldendorp, Gary Morrow, Arthur Reyes, Melissa Cheu, Jessica Li, Jeffrey J. Wallin, Siao Tsai, Laura Sun, Peiyin Wang, Diego Ellerman, Christoph Spiess, Andy Polson, Eric G. Stefanich, Amrita V. Kamath, Meric A. Ovacik

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