Search Results - "pharmacokinetics"

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.... by Ziqiang Li, Xi Du, Shuang Tian, Shanshan Fan, Xurui Zuo, Yanfen Li, Ruihua Wang, Baohe Wang, Yuhong Huang

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Population pharmacokinetics of FCN-159, a MEK1/2 inhibitor, in adult patients with advanced melanoma and neurofibromatosis type 1 (NF1) and model informed dosing recommendations for NF1 pediatrics by Yan Tan, Ailing Cui, Lixuan Qian, Chao Li, Zhuli Wu, Yuchen Yang, Pu Han, Xin Huang, Lei Diao

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An Investigational Study on the Role of <i>CYP2D6</i>, <i>CYP3A4</i> and <i>UGT</i>s Genetic Variation on Fesoterodine Pharmacokinetics in Young Healthy Volunteers by Andrea Rodríguez-Lopez, Dolores Ochoa, Paula Soria-Chacartegui, Samuel Martín-Vilchez, Marcos Navares-Gómez, Eva González-Iglesias, Sergio Luquero-Bueno, Manuel Román, Gina Mejía-Abril, Francisco Abad-Santos

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Pharmacokinetics and bioequivalence of two formulations of mifepristone tablets in healthy Chinese subjects under fasting conditions: a single-center, open, randomized, single-dose, double-period, two-sequence, crossover trial by Yufeng Yan, Xiaoshan Zhu, Ping Dong, Cheng Liu, Lingqing Lu, Liyan Zeng, Guiying Chen, Xianmin Meng, Xianmin Meng, Min Liu

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Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR439459, a TGFβ inhibitor, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors: Findings from a phase 1/1b study by Joaquina C. Baranda, Debbie Robbrecht, Ryan Sullivan, Bernard Doger, Armando Santoro, Minal Barve, Jean‐Jacques Grob, Oliver Bechter, Maria Vieito, Maria Jose deMiguel, Dirk Schadendorf, Melissa Johnson, Clemence Pouzin, Cathy Cantalloube, Rui Wang, Jooyun Lee, Xiaofei Chen, Brigitte Demers, Amele Amrate, Giovanni Abbadessa, F. Stephen Hodi

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Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> by Jiayuan Zhang, Mengyuan Wu, Shuo Diao, Shixing Zhu, Chu Song, Jiali Yue, Frederico S. Martins, Peijuan Zhu, Zhihua Lv, Yuanqi Zhu, Mingming Yu, Sherwin K. B. Sy

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Farmacocinética e análise da distribuição transplacentária da fentanila na assistência anestésica via epidural de gestantes normais Pharmacokinetics and analysis of transplacental distribution of fentanyl in epidural anesthesia for normal pregnant women by Elaine Christine Dantas Moisés, Sérgio Pereira da Cunha

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Comparison of pharmacokinetic profiles of seven major bioactive components in normal and non-alcoholic fatty liver disease (NAFLD) rats after oral administration of Ling-Gui-Zhu-Gan decoction by UPLC-MS/MS by Wenlong Nie, Yang Yang, Ling Li, Ling Li, Yue Ding, Xingmi Chen, Ming Li, Ning He, Guang Ji, Yong Zhang, Ping Kang, Tong Zhang

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Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer by Xin Xu, Xi-yang Sun, Ming Chang, Zhao-liang Hu, Ting-ting Cheng, Tai-jun Hang, Min Song

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Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study by Choi Y, Lee S, Cho SM, Kang WH, Nam KY, Jang IJ, Yu KS

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Correction: König et al. Cefiderocol in Critically Ill Patients with Multi-Drug Resistant Pathogens: Real-Life Data on Pharmacokinetics and Microbiological Surveillance. <i>Antibiotics</i> 2021, <i>10</i>, 649 by Christina König, Anna Both, Holger Rohde, Stefan Kluge, Otto R. Frey, Anka C. Röhr, Dominic Wichmann

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Study on pharmacokinetic and tissue distribution of hyperin, astragalin, kaempferol-3-O-β-D-glucuronide from rats with multiple administrations of Semen Cuscutae processed with salt solution with effect of treating recurrent spontaneous abortion by Zhitong Yang, Kaiwen Chen, Yuting Zhang, Baiyang Xu, Yu Huang, Xue Zhang, Zilu Liu, Tongsheng Wang, Deling Wu, Deling Wu, Deling Wu, Tangyi Peng, Tulin Lu, Hao Cai, Xiaoli Wang, Xiaoli Wang, Xiaoli Wang

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A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (CYP3A5) Genotype by Kotaro Itohara, Ikuko Yano, Tetsunori Tsuzuki, Miwa Uesugi, Shunsaku Nakagawa, Atsushi Yonezawa, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto, Kazuo Matsubara

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Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets by Hwang JG, Yu KS, Lee S

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SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™ by Muhammad Talha Saleem, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Kamran Ahmed, Fahad Siddiqui, Zafar Alam Mahmood, Muhammad Sikandar, Muhammad Suleman Imtiaz

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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib studies in healthy subjects and patients by Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Jerome Oude Nijhuis, Peter Paul De Deyn, Salah Hadi, Jeffrey Harris, Richard M. Tsai, Andres Cruz‐Herranz, Fen Huang, Vincent Tong, Rebecca Erickson, Yuda Zhu, Kimberly Scearce‐Levie, Jennifer Hsiao‐Nakamoto, Xinyan Tang, Megan Chang, Brian M. Fox, Anthony A. Estrada, Robert J. Pomponio, Miguel Alonso‐Alonso, Moshe Zilberstein, Nazem Atassi, Matthew D. Troyer, Carole Ho

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Clinical pharmacokinetics and pharmacodynamics of ongericimab: A potential long‐acting PCSK9 monoclonal antibody in healthy subjects and patients with hypercholesterolemia: Randomized, double‐blind, placebo‐controlled phase Ia and Ib/II studies by Juanjuan Jiang, Li Xu, Lin Chai, Xiaoyuan Guan, Li Zhang, Hong Liu, Yan Yan, Lili Li, Yi Zhao, Xuelian Bai, Lei Tian, Youhong Jia

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A single-dose, randomized, open-labeled, parallel-group study comparing the pharmacokinetics, pharmacodynamics and safety of leuprolide acetate microspheres 3.75 mg and Enantone® 3.75 mg in healthy male subjects by Xingjiang Hu, Qiao Zhang, Yunliang Zheng, You Zhai, Nana Xu, Qingwei Zhao, Jian Liu, Longyan Wan, Jindan Luo

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Unexpected Salt/Cocrystal Polymorphism of the Ketoprofen-Lysine System: Discovery of a New Ketoprofen-<span style="font-variant: small-caps">l</span>-Lysine Salt Polymorph with Different Physicochemical and Pharmacokinetic Properties by Andrea Aramini, Gianluca Bianchini, Samuele Lillini, Simone Bordignon, Mara Tomassetti, Rubina Novelli, Simone Mattioli, Larisa Lvova, Roberto Paolesse, Michele Remo Chierotti, Marcello Allegretti

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Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity of the QX002N anti-IL-17 Monoclonal Antibody: A Phase I, Randomized, Double-Blind, Single Ascending Dose Study in Healthy Chinese Volunteers by Min Wu, Hong Zhang, Qianqian Li, Hong Chen, Min Fang, Lizhi Yang, Yanhua Ding

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