Search Results - "pharmacokinetics"

Impact of a Moderate CYP3A4 Inducer (Bosentan) on Lurbinectedin Pharmacokinetics and Safety in Patients with Advanced Solid Tumors: An Open-Label, Two-Way, Crossover, Phase Ib Drug-Drug Interaction Study by Irene Moreno, Tatiana Hernández, Emiliano Calvo, Salvador Fudio, Carmen Kahatt, Cristian Fernández, Jorge Luis Iglesias, Gema Corral, Laura Pérez-Ramos, Lola Montilla, Ali Zeaiter, Rubin Lubomirov

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Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against <i>Staphylococcus aureus</i> Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction by Roger Henrique Sousa da Costa, Renata Torres Pessoa, Eduardo dos Santos Silva, Isaac Moura Araujo, Sheila Alves Gonçalves, Janaína Esmeraldo Rocha, Francisco Nascimento Pereira Junior, Naiara Cipriano Oliveira, Victor Moreira de Oliveira, Matheus Nunes da Rocha, Emmanuel Silva Marinho, Natália Kelly Gomes de Carvalho, José Galberto Martins da Costa, Hélcio Silva dos Santos, Irwin Rose Alencar de Menezes

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Simultaneous Determination of Chlorogenic Acid Isomers and Metabolites in Rat Plasma Using LC-MS/MS and Its Application to A Pharmacokinetic Study Following Oral Administration of Stauntonia Hexaphylla Leaf Extract (YRA-1909) to Rats by Won-Gu Choi, Ju-Hyun Kim, Dong Kyun Kim, Yongnam Lee, Ji Seok Yoo, Dae Hee Shin, Hye Suk Lee

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A Randomized, Double-Blind, Parallel-Group Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of CMAB015, a Candidate Secukinumab Biosimilar, with Its Reference Product Cosentyx® in Healthy Chinese Male Subjects by Yao F, Wang C, Ding J, Zhang Q, Zheng L, Zhang Q, Yang T, Zhang X, Shan Y, Hou S, Wang H, Zhou R, Hu W

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Dosing Colistimethate Every 8 h Results in Higher Plasma Concentrations of Active Colistin Than Every 12-Hourly Dosing without Increase in Nephrotoxicity: A Phase 1 Pharmacokinetics Trial in Healthy Adult Volunteers by George A. Yendewa, John McLeod Griffiss, Wesley A. Gray, Amanda Healen, Howard M. Proskin, Scott A. Fulton, Mary Ann O'Riordan, Charles Hoppel, Jeffrey L. Blumer, Robert A. Salata

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Pharmacokinetics and safety of highly variable valsartan in single-pill combination with amlodipine versus its generic formulation: a randomized, three-cycle, three-sequence, partially replicated crossover phase I bioequivalence clinical trial by Bo Qiu, Haojing Song, Congyang Ding, Xue Sun, Runxuan Du, Haotian Yang, Wanjun Bai, Zhanjun Dong

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An Intravenous Pharmacokinetic Study of Cannabidiol Solutions in Piglets through the Application of a Validated Ultra-High-Pressure Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Simultaneous Quantification of CBD and Its Carboxylated Metabolite in Plasma by Nathan Koch, Olivier Jennotte, Anna Lechanteur, Marine Deville, Corinne Charlier, Jean-Michel Cardot, Patrice Chiap, Brigitte Evrard

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Comparative Pharmacokinetic Profiles of a Novel Low-dose Micronized-isotretinoin 32 mg Formulation and Lidose-isotretinoin 40 mg in Fed and Fasted Conditions: Two Open-label, Randomized, Crossover Studies in Healthy Adult Participants by Sumit Madan, Sudershan Kumar, Jeanett Segal

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Simultaneous Quantitation of a Novel α1/β1-Blocker TJ0711 and Its Two Metabolites in Dog Plasma Using LC-MS/MS and Its Application to a Pharmacokinetic Study after Intravenous Infusion by Wenwen Zhu, Wanyu Liu, Haojv Li, Guojia Xu, Qian Li, Jiangeng Huang, Gao Li, Luqin Si

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A rapid and sensitive High-Performance Liquid Chromatography method with fluorescence detection for quantification of melatonin in small volume rat plasma samples: application to a preclinical study to determine the oral pharmacokinetics of melatonin under gestational conditions by Alberto Gutiérrez López, Ivan Pantic, Héctor Flores Herrera, José Carlos Aguilar Carrasco

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A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine by Tobias Kanacher, Andreas Lindauer, Enrica Mezzalana, Ingrid Michon, Celine Veau, Jose David Gómez Mantilla, Valerie Nock, Angèle Fleury

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Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate by Magdalena Cwiklinska, Magdalena Cwiklinska, Malgorzata Czogala, Malgorzata Czogala, Kinga Kwiecinska, Kinga Kwiecinska, Anna Madetko-Talowska, Malgorzata Szafarz, Katarzyna Pawinska, Katarzyna Pawinska, Aleksandra Wieczorek, Aleksandra Wieczorek, Tomasz Klekawka, Tomasz Klekawka, Magdalena Rej, Magdalena Rej, Konrad Stepien, Konrad Stepien, Przemyslaw Halubiec, Agnieszka Lazarczyk, Karol Miklusiak, Miroslaw Bik-Multanowski, Walentyna Balwierz, Walentyna Balwierz, Szymon Skoczen, Szymon Skoczen

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A phase 1, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-1905, a long-acting anti-thymic stromal lymphopoietin antibody, in healthy subjects by Yue Fei, Na Li, Weilin Qian, Yang Fan, Yu Shen, Quanren Wang, Kristi McLendon, Kai Shen

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A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Nav1.8 inhibitor, in healthy adults by Hemme J. Hijma, Emilie M. J. vanBrummelen, Pieter S. Siebenga, Geert Jan Groeneveld

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Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [¹⁷⁷Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model by Judith Anna Delage, Alain Faivre-Chauvet, Jacques Barbet, Julie Katrin Fierle, Niklaus Schaefer, George Coukos, David Viertl, Steven Mark Dunn, Silvano Gnesin, John O. Prior

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Large Volume Direct Injection Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry-Based Comparative Pharmacokinetic Study between Single and Combinatory Uses of <i>Carthamus tinctorius</i> Extract and Notoginseng Total Saponins by Jinfeng Chen, Xiaoyu Guo, Yingyuan Lu, Mengling Shi, Haidong Mu, Yi Qian, Jinlong Wang, Mengqiu Lu, Mingbo Zhao, Pengfei Tu, Yuelin Song, Yong Jiang

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Randomized, placebo-controlled, single-blind phase 1 studies of the safety, tolerability, and pharmacokinetics of BRII-196 and BRII-198, SARS-CoV-2 spike-targeting monoclonal antibodies with an extended half-life in healthy adults by Xiaohua Hao, Zheng Zhang, Ji Ma, Lin Cheng, Yun Ji, Yang Liu, Dong Zhao, Wen Zhang, Chunming Li, Li Yan, David Margolis, Qing Zhu, Yao Zhang, Fujie Zhang

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Comparing the effects of two different progesterone vaginal gels, Progeson™ and Crinone™, from pharmacokinetics study to clinical applications in patients undergone fresh embryo transfer and frozen-thawed embryo transfer via natural cycle endometrial preparation protocol by Cheng-Wei Yu, Wei-Jiun Li, Wen-Chi Hsieh, Li-Shan Chen, Yi-Ping Li

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Hidrofluoralcano como propelente dos aerossóis pressurizados de dose medida: histórico, deposição pulmonar, farmacocinética, eficácia e segurança Hydrofluoroalkane as a propellant for pressurized metered-dose inhalers: history, pulmonary deposition, pharmacokinetics, efficacy and safety by Cássio C. Ibiapina, Álvaro A. Cruz, Paulo A. M. Camargos

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TROIKA‐1: A double‐blind, randomized, parallel group, study aimed to demonstrate the equivalent pharmacokinetic profile of HD201, a potential biosimilar candidate to trastuzumab, versus EU‐Herceptin® and US‐Herceptin® in healthy male subjects by Martin Demarchi, Pierre Coliat, Kristi Mclendon, Jocelyn Chung Shii Hii, Peggy Feyaerts, Felicia Ang, Litha Jaison, Filip Deforce, Marie Paule Derde, Michael Jinwoo Kim, Lisa Soyeon Park, Alexandre Detappe, Xavier Pivot

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