Search Results - "pharmacokinetics"

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy by Rajbharan Yadav, Suzanne Schubbert, Patrick G. Holder, Eugene Y. Chiang, Nargess Kiabi, Liz Bogaert, Irene Leung, Rumana Rashid, Kendra N. Avery, Christine Bonzon, John R. Desjarlais, Shomyseh Sanjabi, Amy Sharma, Michelle Lepherd, Amy Shelton, Pam Chan, Yanqiu Liu, Louis Joslyn, Iraj Hosseini, Eric G. Stefanich, Amrita V. Kamath, Matthew J. Bernett, Vittal Shivva

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Effects of Side Chain and Peptide Bond Modifications on the Targeting Properties of Stabilized Minigastrin Analogs by Taraneh Sadat Zavvar, Anton Amadeus Hörmann, Maximilian Klingler, Dominik Summer, Christine Rangger, Laurence Desrues, Hélène Castel, Pierrick Gandolfo, Elisabeth von Guggenberg

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Quantum chemical modelling, molecular docking, synthesis and experimental anti-microbial activity of 1,4-diazepan linked piperidine derivative by Khushbu Agrawal, Tarun M. Patel, Shavi Thakur, Kruti Patel, Sumit Mittal

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Evaluation of limited-sampling strategies to calculate AUC(0-24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus by Carla Galvez, Pía Boza, Mariluz González, Catalina Hormazabal, Marlene Encina, Manuel Azócar, Luis E. Castañeda, Angélica Rojo, María Luisa Ceballos, María Luisa Ceballos, Paola Krall, Paola Krall

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Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development by Muralikrishnan A, Sekar M, Kumarasamy V, Gan SH, Ravi S, Subramaniyan V, Wong LS, Wu YS, Khattulanuar FS, Mat Rani NNI

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Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden... by Yassin Ismail, Yassin Ismail, Dina M. Fahmy, Maivel H. Ghattas, Mai M. Ahmed, Walaa Zehry, Samy M. Saleh, Dina M. Abo-elmatty

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Deciphering the Active Compounds and Mechanisms of HSBDF for Treating ALI via Integrating Chemical Bioinformatics Analysis by Yanru Wang, Xiaojie Jin, Xiaojie Jin, Qin Fan, Chenghao Li, Min Zhang, Yongfeng Wang, Qingfeng Wu, Jiawei Li, Xiuzhu Liu, Siyu Wang, Yu Wang, Ling Li, Jia Ling, Chaoxin Li, Qianqian Wang, Yongqi Liu, Yongqi Liu

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Comparative Effectiveness and Safety of Low-Dose Oral Anticoagulants in Patients With Atrial Fibrillation by Sylvie Perreault, Alice Dragomir, Robert Côté, Aurélie Lenglet, Aurélie Lenglet, Simon de Denus, Simon de Denus, Marc Dorais, Brian White-Guay, James Brophy, Mireille E. Schnitzer, Marie-Pierre Dubé, Marie-Pierre Dubé, Jean-Claude Tardif, Jean-Claude Tardif

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Optimal Weight-Based Dosing of Vancomycin to Achieve an Area Under the Curve of 400 to 600 Stratified by Body Mass Index by Caroline Williams, Anna Mitchell, Jessica Bennett, Ally Ponder

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Relationship Between Linezolid Exposure and the Typical Clinical Laboratory Safety and Bacterial Clearance in Chinese Pediatric Patients by Ben-Nian Huo, Yue-E. Wu, Ling Shu, Ruo-Qi Zhang, Jian-Wen Xiao, Qian-Bo Li, Wei Zhao, Wei Zhao, Yun-Tao Jia, Lin Song

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Comparative Long-Term Effect of Three Anti-P2Y12 Drugs after Percutaneous Angioplasty: An Observational Study Based on Electronic Drug Adherence Monitoring by Valentina Forni Ogna, Isabelle Bassi, Isabelle Menetrey, Olivier Muller, Eric Tousset, Pierre Fontana, Pierre Fontana, Eric Eeckhout, Chin B. Eap, Chin B. Eap, Bernard Vrijens, Michel Burnier, Grégoire Wuerzner

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Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola^® on the Luminal and Systemic Behavior of Loratadin... by Bart Hens, Marival Bermejo, Patrick Augustijns, Rodrigo Cristofoletti, Gregory E. Amidon, Gordon L. Amidon

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Evaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent by Rickardson L, Kutvonen E, Orasniemi S, Högberg M, Kallio MJ, Rehnmark S

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In silico design of novel bioactive molecules to treat breast cancer with chlorogenic acid derivatives: a computational and SAR approach by Renu Sehrawat, Priyanka Rathee, Pooja Rathee, Sarita Khatkar, Esra Küpeli Akkol, Anurag Khatkar, Eduardo Sobarzo-Sánchez, Eduardo Sobarzo-Sánchez

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The development of 177Lu-DOTA-CC-PSMA following a unified "Click Chemistry" protocol of synthesizing metal nuclide-conjugated radiopharmaceuticals by Xiaobei Zheng, Shuai Xue, Zhongqi Zhao, Shuxin Jin, Shuhua He, Lina Jia, Zheng Li, Christian Vanhove, Filip De Vos, Zijun Kuang, Tiantian Wang, Sara Neyt, Lan Zhang, Xiao Li

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Synthesis and Bioactivity of N-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent by Cui AL, Sun WF, Zhong ZJ, Jin J, Xue ST, Wu S, Li YH, Li ZR

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Prediction of efficacy for conversion from adjunctive therapy to monotherapy with eslicarbazepine acetate 800 mg once daily for partial-onset epilepsy by Sunkaraneni S, Passarell JA, Ludwig EA, Fiedler-Kelly J, Pitner JK, Grinnell TA, Blum D

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Rescue Therapy for Supratherapeutic Concentrations of Calcineurin Inhibitors Using Potent Cytochrome P450 Inducers by Seth Duwor, Katharina Enthofer, Christoph Ganter, Prabin Poudel, Anna Svarin, Gerd A. Kullak-Ublick

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Therapeutic effect of fenofibrate for non-alcoholic steatohepatitis in mouse models is dependent on regime design by Xinxue Wang, Jia Luo, Zhuoheng Lu, Shenzhe Fang, Mengxia Sun, Wenjing Luo, Jianwei Shen, Aiming Liu, Hua Ye

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Impact of Early Intrapatient Variability of Tacrolimus Concentrations on the Risk of Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation Using High-Dose Post-Trans... by Daniel N. Marco, María Queralt Salas, Gonzalo Gutiérrez-García, Inés Monge, Gisela Riu, Esther Carcelero, Joan Ramón Roma, Noemí Llobet, Jordi Arcarons, María Suárez-Lledó, Nuria Martínez, Alexandra Pedraza, Ariadna Domenech, Laura Rosiñol, Francesc Fernández-Avilés, Álvaro Urbano-Ispízua, Montserrat Rovira, Mercè Brunet, Carmen Martínez

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