Search Results - "structure–activity relationship"

Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches by David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari

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Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors by Myunghwan Ahn, Seung Eun Park, Jiyeon Choi, Jiahn Choi, Doyoung Choi, Dongju An, Hayoung Jeon, Soowhan Oh, Kiho Lee, Jaehoon Kim, Jaebong Jang, Seyun Kim, Youngjoo Byun

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Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions by Yukiko Miyazaki, Yukiko Miyazaki, Daniel K. Inaoka, Daniel K. Inaoka, Daniel K. Inaoka, Tomoo Shiba, Hiroyuki Saimoto, Takaya Sakura, Eri Amalia, Yasutoshi Kido, Chika Sakai, Mari Nakamura, Anthony L. Moore, Shigeharu Harada, Kiyoshi Kita, Kiyoshi Kita, Kiyoshi Kita

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Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV) by Sameera Senaweera, Tiffany C. Edwards, Jayakanth Kankanala, Yan Wang, Rajkumar Lalji Sahani, Jiashu Xie, Robert J. Geraghty, Zhengqiang Wang

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Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies by Jamshed Iqbal, Mohammed I. El-Gamal, Syeda Abida Ejaz, Joanna Lecka, Jean Sévigny, Chang-Hyun Oh

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Optimization of polyphenol extraction from Vitis vinifera L. leaves, antioxidant activity and its correlation with amelioration effect on AlCl3-induced Alzheimer's disease by Azza Abdelmageed Matloub

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Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes by Silvia Bua, Emanuela Berrino, Sonia Del Prete, Vallabhaneni S. Murthy, Vijayaparthasarathi Vijayakumar, Yasinalli Tamboli, Clemente Capasso, Elisabetta Cerbai, Alessandro Mugelli, Fabrizio Carta, Claudiu T. Supuran

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Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities by Jung-Chun Chu, Hui-Ju Tseng, Sung-Bau Lee, Kai-Cheng Hsu, Ling-Wei Hsin, Ru-Hao Liang, Tony Eight Lin, Nain-Chu Gao, Liang-Chieh Chen, Wan-Hsun Lu, Andrew H.-J Wang, Wei-Jan Huang

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Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety by Wei Gao, Hongxiang Hu, Lipeng Dai, Miao He, Hebao Yuan, Huixia Zhang, Jinhui Liao, Bo Wen, Yan Li, Maria Palmisano, Mohamed Dit Mady Traore, Simon Zhou, Duxin Sun

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Benzo[g]quinazolines as antifungal against candidiasis: Screening, molecular docking, and QSAR investigations by Hatem A. Abuelizz, Ahmed H. Bakheit, Mohamed H. Al-Agamy, Harunor Rashid, Gamal A.E. Mostafa, Rashad Al-Salahi

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Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif by Santosh Kumar Adla, Barbora Slavikova, Hana Chodounska, Vojtech Vyklicky, Marek Ladislav, Pavla Hubalkova, Barbora Krausova, Tereza Smejkalova, Michaela Nekardova, Michaela Nekardova, Marketa Smidkova, Lenka Monincova, Radko Soucek, Ladislav Vyklicky, Eva Kudova

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TNP and its analogs: Modulation of IP6K and CYP3A4 inhibition by Seulgi Lee, Bernie Byeonghoon Park, Hongmok Kwon, Vitchan Kim, Jang Su Jeon, Rowoon Lee, Milan Subedi, Taehyeong Lim, Hyunsoo Ha, Dongju An, Jaehoon Kim, Donghak Kim, Sang Kyum Kim, Seyun Kim, Youngjoo Byun

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Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an o-methoxy phenyl group as potential agents against gastric cancer by Xin Gan, Yuna Wu, Min Zhu, Bo Liu, Miaomiao Kong, Zixuan Xi, Ke Li, Haibao Wang, Tiande Su, Jiali Yao, Fatehi Khushafah, Baozhu Yi, Jiabing Wang, Wulan Li, Jianzhang Wu

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Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition by Patrik Oleksak, Miroslav Psotka, Marketa Vancurova, Olena Sapega, Jana Bieblova, Milan Reinis, David Rysanek, Romana Mikyskova, Katarina Chalupova, David Malinak, Jana Svobodova, Rudolf Andrys, Helena Rehulkova, Vojtech Skopek, Pham Ngoc Lam, Jiri Bartek, Zdenek Hodny, Kamil Musilek

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Synthesis, in silico ADMET prediction analysis, and pharmacological evaluation of sulfonamide derivatives tethered with pyrazole or pyridine as anti-diabetic and anti-Alzheimer's a... by Nagwa M. Abdelazeem, Wael M. Aboulthana, Ashraf S. Hassan, Abdulrahman A. Almehizia, Ahmed M. Naglah, Hamad M. Alkahtani

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Editorial: Antimycobacterial drug discovery: molecular therapeutics and target identification, Volume II by Hendra Gunosewoyo, Gert Kruger

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Erratum: Wnt-pathway inhibitors with selective activity against triple-negative breast cancer: From thienopyrimidine to quinazoline inhibitors by Frontiers Production Office

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A small bioactive glycoside inhibits epsilon toxin and prevents cell death by Abhishek Shivappagowdar, Soumya Pati, Chintam Narayana, Rajagopal Ayana, Himani Kaushik, Raj Sah, Swati Garg, Ashish Khanna, Jyoti Kumari, Lalit Garg, Ram Sagar, Shailja Singh

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Synthesis, antifungal activity, and QSAR studies of 1,6-dihydropyrimidine derivatives by Chirag Rami, Laxmanbhai Patel, Chhaganbhai N Patel, Jayshree P Parmar

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Phytochemical study and evaluation of the antidiabetic and antihyperglycemic activities of the fruit extracts of Physalis peruviana L. (Solanaceae) by Damien S.T. Tshibangu, Fortune S. Kavugho, Carlos N. Kabengele, Adrien T. Masunda, Gédéon N. Bongo, Giresse N. Kasiama, Domaine T. Mwanangombo, Clément L. Inkoto, Clément M. Mbadiko, Benjamin Z. Gbolo, Désiré M. Musuyu, Dorothée D. Tshilanda, Jean Paul K.N. Ngbolua, Pius T. Mpiana

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