Search Results - "structure–activity relationship"

Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators by Suleyman Akocak, Nabih Lolak, Daniela Vullo, Mustafa Durgun, Claudiu T. Supuran

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Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents by Levente Kollár, Katarina Grabrijan, Martina Hrast Rambaher, Krištof Bozovičar, Tímea Imre, György G. Ferenczy, Stanislav Gobec, György M. Keserű

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Semi-synthetic cinnamodial analogues: Structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito Aedes aegypti. by Preston K Manwill, Megha Kalsi, Sijin Wu, Erick J Martinez Rodriguez, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L Rakotondraibe

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Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors by Kaijun Jin, Minjie Liu, Chunlin Zhuang, Erik De Clercq, Christophe Pannecouque, Ge Meng, Fener Chen

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Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes by Yoichi Sunagawa, Masafumi Funamoto, Shogo Sono, Kana Shimizu, Satoshi Shimizu, Mai Genpei, Yusuke Miyazaki, Yasufumi Katanasaka, Eriko Morimoto, Morio Ueno, Maki Komiyama, Hideaki Kakeya, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto

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Exploring the Mechanism of Flavonoids Through Systematic Bioinformatics Analysis by Tianyi Qiu, Dingfeng Wu, LinLin Yang, Hao Ye, Hao Ye, Qiming Wang, Zhiwei Cao, Kailin Tang

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The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX by Michael Kugler, Josef Holub, Jiří Brynda, Klára Pospíšilová, Suzan El Anwar, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, Milan Fábry, Bohumír Grüner, Pavlína Řezáčová

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Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors by Claudia Vergelli, Igor A. Schepetkin, Letizia Crocetti, Antonella Iacovone, Maria Paola Giovannoni, Gabriella Guerrini, Andrei I. Khlebnikov, Samuele Ciattini, Giovanna Ciciani, Mark T. Quinn

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In Silico Searching for Alternative Lead Compounds to Treat Type 2 Diabetes through a QSAR and Molecular Dynamics Study by Nicolás Cabrera, Sebastián A. Cuesta, José R. Mora, Luis Calle, Edgar A. Márquez, Roland Kaunas, José Luis Paz

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Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates by Luca Piemontese, Daniel Tomás, Asha Hiremathad, Vito Capriati, Emanuel Candeias, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos

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Aminoalkylamides of Eremomycin Exhibit an Improved Antibacterial Activity by Elena I. Moiseenko, Réka Erdei, Natalia E. Grammatikova, Elena P. Mirchink, Elena B. Isakova, Eleonora R. Pereverzeva, Gyula Batta, Andrey E. Shchekotikhin

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Limonoids From the Genus Melia (Meliaceae): Phytochemistry, Synthesis, Bioactivities, Pharmacokinetics, and Toxicology by Wenxiang Fan, Linhong Fan, Zhengtao Wang, Li Yang, Li Yang

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Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer's disease by Chen Zhang, Qian Zhou, Xu-Nian Wu, Ya-Dan Huang, Jie Zhou, Zengwei Lai, Yinuo Wu, Hai-Bin Luo

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Mass spectrometry imaging advances and application in pharmaceutical research by Xiaowei Song, Chao Li, Yifan Meng

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Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors by Suleyman Akocak, Nabih Lolak, Silvia Bua, Claudiu T. Supuran

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Bromo-Cyclobutenaminones as New Covalent UDP-<i>N</i>-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors by David J. Hamilton, Péter Ábrányi-Balogh, Aaron Keeley, László Petri, Martina Hrast, Tímea Imre, Maikel Wijtmans, Stanislav Gobec, Iwan J. P. de Esch, György Miklós Keserű

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Design of potent fluoro-substituted chalcones as antimicrobial agents by Serdar Burmaoglu, Oztekin Algul, Arzu Gobek, Derya Aktas Anil, Mahmut Ulger, Busra Gul Erturk, Engin Kaplan, Aylin Dogen, Gönül Aslan

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Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery by Rameshwar S. Cheke, Vaishali M. Patil, Sandip D. Firke, Jaya P. Ambhore, Iqrar A. Ansari, Harun M. Patel, Sachin D. Shinde, Visweswara Rao Pasupuleti, Md Imtaiyaz Hassan, Mohd Adnan, Adel Kadri, Mejdi Snoussi

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Effects of Enzymatically Depolymerized Low Molecular Weight Heparins on CCl4-Induced Liver Fibrosis by Yishu Yan, Changge Guan, Shanshan Du, Wenming Zhu, Yang Ji, Nan Su, Xiang Mei, Dong He, Yuan Lu, Chong Zhang, Chong Zhang, Xin-Hui Xing, Xin-Hui Xing

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Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis by Simone Tasca Cargnin, Andressa Finkler Staudt, Camila Menezes, Ana Paula de Azevedo, Saara Neri Fialho, Tiana Tasca, Carolina Bioni Garcia Teles, Simone Baggio Gnoatto

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