Search Results - "structure–activity relationship"

QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency by Guohui Sun, Peiying Bai, Tengjiao Fan, Lijiao Zhao, Rugang Zhong, R. Stanley McElhinney, T. Brian H. McMurry, Dorothy J. Donnelly, Joan E. McCormick, Jane Kelly, Geoffrey P. Margison

Connect to this object online.

<i>In Silico</i>-Motivated Discovery of Novel Potent Glycogen Synthase-3 Inhibitors: 1-(Alkyl/arylamino)-3H-naphtho[1,2,3-de]quinoline-2,7-dione Identified as a Scaffold for Kinase... by Thomas D. Emmerich, Joseph M. Hayes

Connect to this object online.

Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1 by Jing Zhang, Qiu-Sha Pan, Xing-Kai Qian, Xiang-Lu Zhou, Ya-Jie Wang, Rong-Jing He, Le-Tian Wang, Yan-Ran Li, Hong Huo, Cheng-Gong Sun, Lei Sun, Li-Wei Zou, Ling Yang

Connect to this object online.

Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking by Hatice Yıldırım, Mahmut Yıldız, Nilüfer Bayrak, Emel Mataracı-Kara, Mohamed Osman Radwan, Ayse Tarbin Jannuzzi, Masami Otsuka, Mikako Fujita, Amaç Fatih TuYuN

Connect to this object online.

Anti-allergic Hydroxy Fatty Acids from Typhonium blumei Explored through ChemGPS-NP by Michal Korinek, Michal Korinek, Yi-Hong Tsai, Mohamed El-Shazly, Mohamed El-Shazly, Kuei-Hung Lai, Kuei-Hung Lai, Anders Backlund, Shou-Fang Wu, Shou-Fang Wu, Wan-Chun Lai, Tung-Ying Wu, Shu-Li Chen, Yang-Chang Wu, Yang-Chang Wu, Yang-Chang Wu, Yuan-Bin Cheng, Yuan-Bin Cheng, Yuan-Bin Cheng, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Bing-Hung Chen, Bing-Hung Chen, Bing-Hung Chen, Fang-Rong Chang, Fang-Rong Chang, Fang-Rong Chang, Fang-Rong Chang, Fang-Rong Chang

Connect to this object online.

Ecust004 Suppresses Breast Cancer Cell Growth, Invasion, and Migration via EMT Regulation by Liu Z, Huang L, Sun L, Nie H, Liang Y, Huang J, Wu F, Hu X

Connect to this object online.

Computational guided identification of potential leads from Acacia pennata (L.) Willd. as inhibitors for cellular entry and viral replication of SARS-CoV-2 by James H. Zothantluanga, Neelutpal Gogoi, Anshul Shakya, Dipak Chetia, H. Lalthanzara

Connect to this object online.

Analysis of Survival Modification by Furosemide Use in a Cohort of Hospitalized COVID-19 Patients with Severe or Critical Disease in Mexico: Due to Its Chemical Structure, Furosemi... by Janet Diaz-Martinez, Wayne Kotzker, Martha A. Mendoza-Hernandez, Rajdeep S. Gadh, Gustavo A. Hernandez-Fuentes, Andrew Bañuelos, José Guzmán-Esquivel, Angelina Hong, Osiris G. Delgado-Enciso, Elizabeth Geyer-Roberts, Margarita L. Martinez-Fierro, Iram P. Rodriguez-Sanchez, Idalia Garza-Veloz, Luis M. Canseco-Ávila, Ivan Delgado-Enciso

Connect to this object online.

Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits NaV1.8 via Interactions With the DI Voltage Sensor and DII Pore Module by Kiran George, Diego Lopez-Mateos, Diego Lopez-Mateos, Tarek Mohamed Abd El-Aziz, Tarek Mohamed Abd El-Aziz, Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Hong Bao, Syed Raza, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Matthew P. Rowe, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy, Ashlee H. Rowe, Ashlee H. Rowe

Connect to this object online.

Antimicrobial and antifungal activity of 2-(1H-tetrazolo-5-yl)anilines and products of their structural modifications by O. M. Antypenko, I. M. Vasileva, S. I. Kovalenko

Connect to this object online.

A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays by Stephen H. Kasper, Stephanie Otten, Brian Squadroni, Cionna Orr‐Terry, Yi Kuang, Lily Mussallem, Lan Ge, Lin Yan, Srinivasaraghavan Kannan, Chandra S. Verma, Christopher J. Brown, Charles W. Johannes, David P. Lane, Arun Chandramohan, Anthony W. Partridge, Lee R. Roberts, Hubert Josien, Alex G. Therien, Erik C. Hett, Bonnie J. Howell, Andrea Peier, Xi Ai, Jason Cassaday

Connect to this object online.

Synthesis, Anticancer, Antimicrobial and Antioxidant Potential of Novel 4-(Substituted phenyl-1,3,4-oxadiazol/thiadiazol-2-yl)-4-(4-substituted phenyl) Azetidin-2-One Derivatives by Davinder Kumar, Navidha Aggarwal, Virender Kumar, Harsh Kumar, Aakash Deep, Shabana Bibi, Hitesh Chopra, Rakesh Kumar Marwaha, Abdulrahman Alshammari, Metab Alharbi, Abdul Hayee

Connect to this object online.

Antihypertensive effects of pentacyclic triterpenoid from Convolvulus pluricaulis and its plausible mechanism of action hypothesizing its selectivity targeting Mineralocorticoid re... by Kanagasabai Somarathinam, Seshan Gunalan, Ananthasri Sailapathi, Dharani Amirtha Metilda A, Balashanmugam Pannerselvam, M. Mohanasundari, Ashok Kumar Balaraman, Gugan Kothandan

Connect to this object online.

In Vitro and In Vivo Antiviral Studies of New Heteroannulated 1,2,3-Triazole Glycosides Targeting the Neuraminidase of Influenza A Viruses by Omnia Kutkat, Ahmed Kandeil, Yassmin Moatasim, Yaseen A. M. M. Elshaier, Wael A. El-Sayed, Samir T. Gaballah, Ahmed El Taweel, Mina Nabil Kamel, Mohamed El Sayes, Mohammed A. Ramadan, Rabeh El-Shesheny, Farouk M. E. Abdel-Megeid, Richard Webby, Ghazi Kayali, Mohamed A. Ali

Connect to this object online.

Bio-guided isolation of anti-leishmanial natural products from Diospyros gracilescens L. (Ebenaceae) by Cyrille Armel N. Njanpa, Steven Collins N. Wouamba, Lauve Rachel T. Yamthe, Darline Dize, Brice Mariscal T. Tchatat, Patrick Valère F. Tsouh, Michel Nguiam Pouofo, Jean Bosco Jouda, Bruno Lenta Ndjakou, Norbert Sewald, Simeon Fogue Kouam, Fabrice Fekam Boyom

Connect to this object online.

Synthesis of 2-phenyl- and 2-benzyl derivatives of 4(3Н)-quinazolinone with analgesic activity by I. P. Kodonidi, A. V. Bicherov, E. A. Manvelyan, A. A. Kolodina, A. A. Bicherov, M. M. Manvelyan, A. V. Ivchenko, N. N. Vdovenko-Martynova, A. T. Navalieva, M. M. Manvelyan

Connect to this object online.

Synthesis and anаlgеsic properties of (3-allyl-4-aryl-3H-thiazol-2-ylidene)-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]amine derivatives by S. A. Demchenko, H. O. Yeromina, L. O. Perekhoda, T. A. Bukhtiarova, L. S. Bobkova, A. M. Demchenko

Connect to this object online.

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential by Michela De Bellis, Francesca Sanarica, Alessia Carocci, Giovanni Lentini, Sabata Pierno, Jean-François Rolland, Diana Conte Camerino, Annamaria De Luca

Connect to this object online.

3D-QSAR studies on CCR2B receptor antagonists: Insight into the structural requirements of (R)-3-aminopyrrolidine series of molecules based on CoMFA/CoMSIA models by Swetha Gade, Shaik Mahmood

Connect to this object online.

Overview of P-glycoprotein inhibitors: a rational outlook by Kale Mohana Raghava Srivalli, P. K. Lakshmi

Connect to this object online.