Search Results - "translational science"

Website for families of non-breastfed children: development and validation of content and interface by Marília Alessandra Bick, Cristiane Cardoso de Paula

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Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling by Venkata K. Yellepeddi, Kaustubh Parashar, Spencer M. Dean, Kevin M. Watt, Jonathan E. Constance, Olga J. Baker

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Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism by Hye‐Rim Kang, Eric A. Dietrich, Pei‐Lin Huang, Wei‐Hsuan Lo‐Ciganic, Christina E. DeRemer, Haesuk Park

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Use of Titration as a Therapeutic Individualization Strategy: An Analysis of Food and Drug Administration-Approved Drugs by Robert N. Schuck, Michael Pacanowski, Sarah Kim, Rajanikanth Madabushi, Issam Zineh

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Practical guide to SHAP analysis: Explaining supervised machine learning model predictions in drug development by Ana Victoria Ponce‐Bobadilla, Vanessa Schmitt, Corinna S. Maier, Sven Mensing, Sven Stodtmann

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US, EU, and Japanese Regulatory Guidelines for Development of Drugs for Treatment of Alzheimer's Disease: Implications for Global Drug Development by Anne Vinther Morant, Henrik Tang Vestergaard, Anders Blædel Lassen, Vaidrius Navikas

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Impact of P‐gp inhibition on systemic exposure of pralsetinib and dosing considerations by Julia Suchomel, Priya Agarwal, Doreen Anders, Kevin Hughes, Yang Tang, Rucha Sane, Astrid Scalori, Sunil Sharma, Sravanthi Cheeti

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Pragmatic Trials in Genomic Medicine: The Integrating Pharmacogenetics In Clinical Care (I‐PICC) Study by Charles A. Brunette, Stephen J. Miller, Nilla Majahalme, Cynthia Hau, Lauren MacMullen, Sanjay Advani, Sophie A. Ludin, Andrew J. Zimolzak, Jason L. Vassy

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Physicochemical properties determining drug detection in skin by Wout Bittremieux, Rohit S. Advani, Alan K. Jarmusch, Shaden Aguirre, Aileen Lu, Pieter C. Dorrestein, Shirley M. Tsunoda

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Translation of the efficacy of antibody-drug conjugates from preclinical to clinical using a semimechanistic PK/PD model: A case study with RC88 by Qiaoning Li, Ling Wang, Jinfeng Zhang, Guorui Zhao, Zhihao Liu, Xinting Ma, Jing Jiang

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Exposure-Response Analysis of Overall Survival for Tremelimumab in Unresectable Malignant Mesothelioma: The Confounding Effect of Disease Status by Paul Baverel, Lorin Roskos, Manasa Tatipalli, Nancy Lee, Paul Stockman, Maria Taboada, Paolo Vicini, Kevin Horgan, Rajesh Narwal

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Deriving protein binding‐corrected chemical concentrations for in vitro testing by Aditya R. Kolli

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A Modeling Framework to Characterize Cytokine Release upon T‐Cell-Engaging Bispecific Antibody Treatment: Methodology and Opportunities by Xiaoying Chen, Cris Kamperschroer, Gilbert Wong, Dawei Xuan

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Once‐Daily Oxycodone Prolonged‐Release Tablets Are Resistant to Alcohol‐Induced Dose Dumping: Results From a Randomized Trial in Healthy Volunteers by Nils Burger, Douglas Fraser, Martina Alice Maritz, Janice Faulkner, Helene Rey

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Regulation of exosomes as biologic medicines: Regulatory challenges faced in exosome development and manufacturing processes by Chun‐Kai Wang, Teng‐Huang Tsai, Chung‐Hsi Lee

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Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy by Eric Reyner, Bert Lum, Jing Jing, Matts Kagedal, Joseph A. Ware, Leslie J. Dickmann

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Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects... by Mark Forman, John Palcza, Jack Tseng, Julie A. Stone, Brittany Walker, Dennis Swearingen, Matthew D. Troyer, Marissa F. Dockendorf

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Quantitative Clinical Pharmacology of T‐Cell Engaging Bispecifics: Current Perspectives and Opportunities by Peter N. Morcos, Junyi Li, Iraj Hosseini, Chi‐Chung Li

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Exploratory Analysis of the Factors Associated With Success Rates of Confirmatory Randomized Controlled Trials in Cancer Drug Development by Can Wu, Shunsuke Ono

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Metabolomic Differentials in Women With and Without Fibromyalgia by Victoria Menzies, Angela Starkweather, Yingwei Yao, Leroy R. Thacker II, Timothy J. Garrett, Theresa Swift‐Scanlan, Debra Lynch Kelly, Param Patel, Debra E. Lyon

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