Search Results - "translational science"

Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure by Imad Kassem, Steven Sanche, Jun Li, Guillaume Bonnefois, Marie‐Pierre Dubé, Jean‐Lucien Rouleau, Jean‐Claude Tardif, Michel White, Jacques Turgeon, Fahima Nekka, Simon deDenus

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Assessment of CYP‐Mediated Drug Interactions for Evocalcet, a New Calcimimetic Agent, Based on In Vitro Investigations and a Cocktail Study in Humans by Kazuya Narushima, Hiroshi Maeda, Masanari Shiramoto, Yuichi Endo, Satoko Ohtsuka, Hiroaki Nakamura, Yoshinori Nagata, Tatsuo Uchimura, Ayako Kannami, Ryutaro Shimazaki, Masafumi Fukagawa, Tadao Akizawa

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Increasing acceptance of AI‐generated digital twins through clinical trial applications by Anna A. Vidovszky, Charles K. Fisher, Anton D. Loukianov, Aaron M. Smith, Eric W. Tramel, Jonathan R. Walsh, Jessica L. Ross

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First‐in‐human study of deucravacitinib: A selective, potent, allosteric small‐molecule inhibitor of tyrosine kinase 2 by Ian M. Catlett, Urvi Aras, Lars Hansen, Yali Liu, Di Bei, Ihab G. Girgis, Bindu Murthy

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Models of Variability and Circadian Rhythm in Heart Rate, Blood Pressure, and QT Interval for Healthy Subjects Who Received Placebo in Phase I Trials by Mukul Minocha, Hong Li, Yi‐Lin Chiu, David Carter, Ahmed A. Othman

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First‐in‐Human, Healthy Volunteers Integrated Protocol of ETC‐206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug by Vincenzo Teneggi, Veronica Novotny‐Diermayr, Lay Hoon Lee, Maryam Yasin, Pauline Yeo, Kantharaj Ethirajulu, Sylvia Bong Hwa Gan, Stephanie E. Blanchard, Ranjani Nellore, Dhananjay N. Umrani, Roberto Gomeni, Darren Lim Wan Teck, Greg Li, Qing Shu Lu, Yang Cao, Alex Matter

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Induction of CD8+ immune memory and enhanced inflammation in a skin inflammation model through pre‐immunization with inactivated pathogens by Caroline Falkenberg, Christina Bartholdy, Janne Koch, Martin Fitzner Toft, Søren Skov, Camilla Hartmann Friis Hansen, Axel Kornerup Hansen

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How can real‐world evidence aid decision making during the life cycle of nonprescription medicines? by Emese Csoke, Sabine Landes, Matthew J. Francis, Larry Ma, Denise Teotico Pohlhaus, Christelle Anquez‐Traxler

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Influence of Rifampin‐Mediated Organic Anion‐Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan by Pierre‐Eric Juif, Christine Voors‐Pette, Mike Ufer, Peter Dogterom, Jasper Dingemanse

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DNA methyltransferase inhibitor exposure-response: Challenges and opportunities by Amanda B. Kagan, Dominique A. Garrison, Nicole M. Anders, Jonathan A. Webster, Sharyn D. Baker, Srinivasan Yegnasubramanian, Michelle A. Rudek

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Prediction of molecular phenotypes for novel SCN1A variants from a Turkish genetic epilepsy syndromes cohort and report of two new patients with recessive Dravet syndrome by Kerem Teralı, Ayberk Türkyılmaz, Safiye Güneş Sağer, Alper Han Çebi

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Non‐synonymous alterations in AKR7A3 and ABCA6 correlate with bleeding in aged patients treated with rivaroxaban by Ming Zhao, Qiang Zhang, Xizi Wang, Qianqian Zhang, Conghui Tian, Rongrong Li, Xiaodong Jia, Mingliang Gu, Liping Yang

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Diabetic kidney diseases revisited: A new perspective for a new era by Haiyan Fu, Silvia Liu, Sheldon I. Bastacky, Xiaojie Wang, Xiao-Jun Tian, Dong Zhou

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Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects by Susan Bellaire, Mark Walzer, Tianli Wang, Walter Krauwinkel, Nancy Yuan, Gerard J. Marek

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Digital health technology derived measures: Biomarkers or clinical outcome assessments? by Elena S. Izmailova, Charmaine Demanuele, Marie McCarthy

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Optimizing clinical phenotyping to better delineate the complex relationship between type 2 diabetes and Alzheimer's disease by Angela J. Hanson, Katya B. Rubinow

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Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV‐50717) Compared With Tetrabenazine in Healthy Volunteers by Frank Schneider, Margaret Bradbury, Thomas A. Baillie, David Stamler, Edward Hellriegel, Donna S. Cox, Pippa S. Loupe, Juha‐Matti Savola, Laura Rabinovich‐Guilatt

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Generalizability in real‐world trials by Anatol‐Fiete Näher, Marvin Kopka, Felix Balzer, Matthias Schulte‐Althoff

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Impact of Insulin Tregopil and Its Permeation Enhancer on Pharmacokinetics of Metformin in Healthy Volunteers: Randomized, Open‐Label, Placebo‐Controlled, Crossover Study by Anand Khedkar, Harold Lebovitz, Alexander Fleming, Alan Cherrington, Vinu Jose, Sandeep N. Athalye, Ashwini Vishweswaramurthy

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Quantitative systems pharmacology modeling of macrophage‐targeted therapy combined with PD‐L1 inhibition in advanced NSCLC by Hanwen Wang, Theinmozhi Arulraj, Samira Anbari, Aleksander S. Popel

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