Search Results - "translational science"

Assessment of the impact of Japanese‐specific long‐term safety data on new drug approval by Shinobu Uzu, Shohko Sekine, Junichi Asano, Mutsuhiro Ikuma

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Early Clinical Experience With AZD4831, A Novel Myeloperoxidase Inhibitor, Developed for Patients With Heart Failure With Preserved Ejection Fraction by Karin Nelander, Maria Lagerstrom‐Fermer, Carl Amilon, Erik Michaëlsson, Maria Heijer, Magnus Kjaer, Muir Russell, David Han, Eva‐Lotte Lindstedt, Carl Whatling, Li‐Ming Gan, Hans Ericsson

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Anti‐inflammatory effects of dexamethasone in COVID‐19 patients: Translational population PK/PD modeling and simulation by Artur Świerczek, William J. Jusko

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Model‐based dose selection to inform translational clinical oncology development of WNT974, a first‐in‐class Porcupine inhibitor by Yan Ji, Pai‐Hsi Huang, Steve Woolfenden, Andrea Myers

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Computational models in inflammatory bowel disease by Philippe Pinton

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Alkylating agents‐induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front by Sruthi Sriram, Tiago Macedo, Annelies Mavinkurve‐Groothuis, Marianne van deWetering, Leendert H. J. Looijenga

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Electrocardiographic Effects of a Supratherapeutic Dose of WCK 2349, a Benzoquinolizine Fluoroquinolone by Jay W. Mason, Rakesh Chugh, Anasuya Patel, Ranjeet Gutte, Ashima Bhatia

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Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation-A Potentially Beneficial Drug‐Drug Interaction by Tuija Tapaninen, Aleksi M. Olkkola, Aleksi Tornio, Mikko Neuvonen, Erkki Elonen, Pertti J. Neuvonen, Mikko Niemi, Janne T. Backman

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Relationship Between Plasma Concentrations and Clinical Effects of Cariprazine in Patients With Schizophrenia or Bipolar Mania by Antonia Periclou, Susan Willavize, David Jaworowicz, Julie Passarell, Timothy Carrothers, Parviz Ghahramani, Suresh Durgam, Willie Earley, Margit Kapás, Tatiana Khariton

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In Silico Approach to Predict Severe Cutaneous Adverse Reactions Using the Japanese Adverse Drug Event Report Database by Kaori Ambe, Kazuyuki Ohya, Waki Takada, Masaharu Suzuki, Masahiro Tohkin

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Machine learning framework to predict pharmacokinetic profile of small molecule drugs based on chemical structure by Nikhil Pillai, Alexandra Abos, Donato Teutonico, Panteleimon D. Mavroudis

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Drugs used for the treatment of cerebral and disseminated infections caused by free‐living amoebae by Alexandre Taravaud, Zineb Fechtali‐Moute, Philippe M. Loiseau, Sébastien Pomel

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A case study of inclusion of rural populations in research: Implications for science and health equity by Devon Noonan, Wendy K. K. Lam, James Goodrich, Sydney Sullivan, Keisha Bentley‐Edwards, Dwight Koeberl, Anushka Palipana, F. Joseph McClernon

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Evaluation of the safety, tolerability, and pharmacokinetics of RO7049389 in healthy Chinese volunteers by Xiaojie Wu, Sheng Feng, Jing Zhang, Wenhong Zhang, Yuchen Zhang, Mingfen Zhu, Miriam Triyatni, Na Zhao, Qingyan Bo, Yuyan Jin

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Pediatric growth patterns in youth‐onset type 2 diabetes mellitus: Implications for physiologically‐based pharmacokinetic models by Chelsea M. Hosey, Kelsee Halpin, Valentina Shakhnovich, Chengpeng Bi, Brooke Sweeney, Yun Yan, J. Steven Leeder

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Differential effects of metformin‐mediated BSEP repression on pravastatin and bile acid pharmacokinetics in humans: A randomized controlled trial by Melissa Metry, Samuel A. Krug, Vijaya Kumari Karra, Maureen A. Kane, Jeffrey C. Fink, Yan Shu, Hongbing Wang, James E. Polli

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Assessment of Patient Knowledge and Perceptions of Pharmacogenomics Before and After Using a Mock Results Patient Web Portal by Tien M. Truong, Elizabeth Lipschultz, Keith Danahey, Emily Schierer, Mark J. Ratain, Peter H. O'Donnell

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Piloting a Nationally Disseminated, Interactive Human Subjects Protection Program for Community Partners: Unexpected Lessons Learned from the Field by Stephanie Solomon, Sherita Bullock, Karen Calhoun, Lori Crosby, Brenda Eakin, Zeno Franco, Emily Hardwick, Andrea Leinberger‐Jabari, Gail Newton, Jere Odell, Adam Paberzs, Ryan Spellecy

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Noninvasive skin swab analysis detects environmental drug exposure of pharmacy staff by Samantha Thompson, Samvel Abelyan, Morgan Panitchpakdi, Jasmine Zemlin, Sydney Thomas, Haoqi Nina Zhao, Pieter C. Dorrestein, Shirley M. Tsunoda

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A retrospective analysis of actionable pharmacogenetic/genomic biomarker language in FDA labels by Shinji Yamazaki

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