Search Results - "translational science"

Translational pharmacokinetic/pharmacodynamic model for mRNA‐0184, an investigational therapeutic for the treatment of heart failure by Neeraj Kaushal, Husain Attarwala, Mir Javid Iqbal, Rajnish Saini, Linh Van, Min Liang

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Characterizing Pharmacogenetic Testing Among Children's Hospitals by Jacob T. Brown, Laura B. Ramsey, Sara L. Van Driest, Ida Aka, Susan I. Colace

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Intra‐arterial combination therapy for experimental acute ischemic stroke by Michael E. Maniskas, Jill M. Roberts, Amanda Gorman, Gregory J. Bix, Justin F. Fraser

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Mitigating ipatasertib‐induced glucose increase through dose and meal timing modifications by Dhruvitkumar S. Sutaria, Priya Agarwal, Kuan‐Chieh Huang, Dale R. Miles, Jacob Rotmensch, Heather Hinton, Jorge Daniel Gallo, Grozdana Rasuo, Rucha S. Sane

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Rethinking, reducing, and refining the classical oral tyramine challenge test of monoamine oxidase (MAO) inhibitors by Ewoud‐Jan vanHoogdalem, Karen L. Smith, Jan Hartstra, John Constant

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Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys by Yaofeng Cheng, Xiaomin Liang, Jia Hao, Congrong Niu, Yurong Lai

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Safety, tolerability, pharmacokinetic, and pharmacodynamic characteristics of vutiglabridin: A first‐in‐class, first‐in‐human study by Joo Young Na, Deok Yong Yoon, Hyounggyoon Yoo, SeungHwan Lee, Kyung‐Sang Yu, In‐Jin Jang, Sang‐Ku Yoo, Youngah Kim, Jaeseong Oh

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Effects of Temsavir, Active Moiety of Antiretroviral Agent Fostemsavir, on QT Interval: Results From a Phase I Study and an Exposure-Response Analysis by Chakradhar Lagishetty, Katy Moore, Peter Ackerman, Cyril Llamoso, Mindy Magee

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Effects of Common CYP1A2 Genotypes and Other Key Factors on Intraindividual Variation in the Caffeine Metabolic Ratio: An Exploratory Analysis by Dan‐Dan Tian, Senthil Natesan, John R. White , Jr, Mary F. Paine

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The effect of neuropsychiatric medication on pediatric nonalcoholic fatty liver disease by Jamie L. Ryan, Ashley K. Sherman, Daniel E. Heble, Craig A. Friesen, James F. Daniel, Ryan T. Fischer, Voytek Slowik

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Reduced Risk of Sinusoidal Obstruction Syndrome of the Liver after Busulfan‐Cyclophosphamide Conditioning Prior to Allogeneic Hematopoietic Stem Cell Transplantation by Ibrahim El‐Serafi, Mats Remberger, Olle Ringdèn, Johan Törlén, Mikael Sundin, Andreas Björklund, Jacek Winiarski, Jonas Mattsson

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Associations of HLA‐C*01:02 and HLA‐B*46:01 with regorafenib‐induced erythema multiforme in Japanese patients with metastatic colorectal cancer by Ken‐ichi Fujita, Natsumi Matsumoto, Remi Murase, Kosuke Takeshima, Hiroo Ishida, Yutaro Kubota

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Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of Vixotrigine in Healthy Volunteers by Himanshu Naik, Deb J. Steiner, Mark Versavel, Joanne Palmer, Regan Fong

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Dose Finding in the Clinical Development of 60 US Food and Drug Administration-Approved Drugs Compared With Learning vs. Confirming Recommendations by Yassine Kamal Lyauk, Daniël Martijn Jonker, Trine Meldgaard Lund

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Pharmacokinetics and tolerability of apremilast in healthy Korean adult men by Ki Young Huh, Yewon Choi, Jim Nissel, Maria Palmisano, Xiaomin Wang, Liangang Liu, Francisco Ramirez‐Valle, Howard Lee

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On placental and lactational transfer of IgG‐based therapeutic proteins - Current understanding and knowledge gaps from a clinical pharmacology perspective by Daphne Guinn, Katherine Kratz, Kristie Baisden, Sarah Ridge, Sonaly McClymont, Elimika Pfuma Fletcher, Tamara Johnson, Yow‐Ming Wang

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International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs by Ingrid M. Pruimboom‐Brees, Swati Gupta, Nagendra Chemuturi, Helen S. Booler, Erik Nimz, Meg Ferrell Ramos, Antonello Caruso, Katie F. Maass, Vladimir Bantseev, Qihong Huang, Mary P. Choules, Jesse C. Nussbaum, Jitendra Kanodia, Christopher Thompson, Chandrasekar Durairaj

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Expression of Paracrine Effectors in Human Adipose‐Derived Mesenchymal Stem Cells Treated With Plasma From Brown Bears (Ursus arctos) by Maria Berg von Linde, Karin Johansson, Robert Kruse, Gisela Helenius, Ninos Samano, Örjan Friberg, Anne Mette Frøbert, Ole Fröbert

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Using electronic health records for clinical pharmacology research: Challenges and considerations by Eissa Jafari, Marisa H. Blackman, Jason H. Karnes, Sara L. Van Driest, Dana C. Crawford, Leena Choi, Caitrin W. McDonough

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A systematic review and meta‐analysis of studies that have evaluated the role of mitochondrial function and iron metabolism in frailty by Kristina Tomkova, Suraj Pathak, Riccardo Abbasciano, Marcin Wozniak, Gavin J. Murphy

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