Search Results - "translational science"

Evaluation of factors associated with recruitment rates in early phase clinical trials based on the European Clinical Trials Register data by Paloma Moraga Alapont, Paula Prieto, Mikel Urroz, María Jiménez, Antonio J. Carcas, Alberto M. Borobia

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Hybrid physiologically‐based pharmacokinetic model for remdesivir: Application to SARS‐CoV‐2 by James M. Gallo

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An evaluation of a supratherapeutic dose of inclisiran on cardiac repolarization in healthy volunteers: A phase I, randomized study by David Kallend, Jay Mason, Patrick F. Smith, Michael J. Koren, Robert Stoekenbroek, YanLing He, Peter Wijngaard

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Developing a mechanistic translational PK/PD model for a trifunctional NK cell engager to predict the first‐in‐human dose for acute myeloid leukemia by Siak‐Leng Choi, Delphine Valente, Angela Virone‐Oddos, Christine Mauriac

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Efficacy of add‐on therapy with intravenous immunoglobulin in steroid hyporesponsive DRESS syndrome by Da Woon Sim, Jieun Yu, Young‐Il Koh

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Risk assessment of drug-drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach by Yulia Vugmeyster, George Locke, Christoph Helwig, P. Alexander Rolfe, Jennifer Q. Dong, Karthik Venkatakrishnan

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Population pharmacokinetics and exposure‐response analyses of teduglutide in adult and pediatric patients with short bowel syndrome by Jean‐Francois Marier, Claudia Jomphe, Thomas Peyret, Yi Wang

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The necessary conduct: Exploratory multiregional clinical trials in East Asia by Inseung Jeon, Yu Kyong Kim, Ildae Song, Deok Yong Yoon, Ki Young Huh, Xuanyou Jin, Kyung‐Sang Yu, SeungHwan Lee, Yuji Kumagai, In‐Jin Jang

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Role for Drug Transporters in Chemotherapy‐Induced Peripheral Neuropathy by Tore B. Stage, Shuiying Hu, Alex Sparreboom, Deanna L. Kroetz

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Persistent follicular granulosa cell senescence and apoptosis induced by methotrexate leading to oocyte dysfunction and aberrant embryo development by Jingbo Fu, Yang Liu, Chen Wang, Hongxia Zhang, Bin Yu, Ye Wang, Haiying Zhu

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Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Gr... by Kelly E. Caudle, Katrin Sangkuhl, Michelle Whirl‐Carrillo, Jesse J. Swen, Cyrine E. Haidar, Teri E. Klein, Roseann S. Gammal, Mary V. Relling, Stuart A. Scott, Daniel L. Hertz, Henk‐Jan Guchelaar, Andrea Gaedigk

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Pharmacogenomic‐based personalized medicine: Multistakeholder perspectives on implementational drivers and barriers in the Canadian healthcare system by Mathushan Subasri, David Barrett, Jovana Sibalija, Lisa Bitacola, Richard B. Kim

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Making Better Dose Decisions: Using Exposure‐Response Modeling to Integrate Efficacy Outcome of Two Phase IIb Clinical Trials of Ubrogepant for Migraine Treatment by Chi‐Chung Li, Tiffini Voss, Ken Kowalski, Bei Yang, Huub Jan Kleijn, Christopher J. Jones, Rolien Bosch, David Michelson, Matthew DeAngelis, Yang Xu, Iris Xie, Prajakti A. Kothare

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Pharmacokinetics of intranasal amiloride in healthy volunteers by Venkata K. Yellepeddi, Marco Battaglia, Simon J. C. Davies, Jeremiah Alt, Shaelene Ashby, Paige Shipman, David J. Anderson, Joseph E. Rower, Christopher Reilly, Michael Voight, Sabiha Rahman Mim

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Homocysteine Metabolism in Children with Idiopathic Nephrotic Syndrome by Mohan Kundal, Abhijeet Saha, N.K. Dubey, Kanika Kapoor, Trayambak Basak, Gaurav Bhardwaj, Vinay Singh Tanwar, Shantanu Sengupta, Vinita Batra, Ashish Dutt Upadhayay, Ajay Bhatt

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Patterns of pharmacogenetic variation in nine biogeographic groups by Sophia Hernandez, Lucia A. Hindorff, Joannella Morales, Erin M. Ramos, Teri A. Manolio

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PedCRIN tool for the biosamples management in pediatric clinical trials by Viviana Giannuzzi, Lucia Ruggieri, Rosa Conte, Cristina Manfredi, Mariagrazia Felisi, Christine Kubiak, Mihaela Matei, Salma Malik, Jacques Demotes, Adriana Ceci, Donato Bonifazi

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HLA‐associated adverse drug reactions ‐ scoping review by Chiara Jeiziner, Ursina Wernli, Katja Suter, Kurt E. Hersberger, Henriette E. Meyer zu Schwabedissen

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Prevalence of actionable pharmacogenetic variants and high‐risk drug prescriptions: A Swiss hospital‐based cohort study by Flavia Hodel, Maria B. De Min, Christian Wandall Thorball, Claire Redin, Peter Vollenweider, François Girardin, Jacques Fellay

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An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites by Marc‐Olivier Pilon, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus

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