Search Results - "translational science"

Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT‐Prolonging Drugs by Ksenia Blinova, Derek Schocken, Dakshesh Patel, Chathuri Daluwatte, Jose Vicente, Joseph C. Wu, David G. Strauss

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Fetal spina bifida associates with dysregulation in nutrient‐sensitive placental gene networks: Findings from a matched case-control study by Marina White, Jayden Arif‐Pardy, Tim Van Mieghem, Kristin L. Connor

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Population pharmacokinetic/pharmacodynamic assessment of imipenem/cilastatin/relebactam in patients with hospital‐acquired/ventilator‐associated bacterial pneumonia by Munjal Patel, Francesco Bellanti, Naveen M. Daryani, Nadia Noormohamed, David W. Hilbert, Katherine Young, Pooja Kulkarni, William Copalu, Ferdous Gheyas, Matthew L. Rizk

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Population pharmacokinetics and exposure‐response modeling analyses of guselkumab in patients with psoriatic arthritis by Yang Chen, Xin Miao, Chyi‐Hung Hsu, Yanli Zhuang, Alexa Kollmeier, Zhenhua Xu, Honghui Zhou, Amarnath Sharma

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Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug‐induced heart rate changes by Logan Brooks, Michael Dolton, Jurgen Langenhorst, Kenta Yoshida, Yi Ting (Kayla), Vikram Malhi, Chunze Li, Pablo Perez‐Moreno, John Bond, Ya‐Chi Chen, Jiajie Yu

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Population genetics of PDE4B (phosphodiesterase‐4B) in neglected Native Americans: Implications for cancer pharmacogenetics by Rennan Garcias Moreira, Julia Maria Saraiva‐Duarte, Alexandre Costa Pereira, Martha Sosa‐Macias, Carlos Galaviz‐Hernandez, Meddly Lesley Santolalla, Wagner C. S. Magalhães, Camila Zolini, Thiago Peixoto Leal, Zsolt Balázs, Adrián Llerena, Robert H. Gilman, José Geraldo Mill, Victor Borda, Heinner Guio, Timothy D. O'Connor, Eduardo Tarazona‐Santos, Fernanda Rodrigues‐Soares

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Assessment of the physical dependence potential of difelikefalin: Randomized placebo‐controlled study in patients receiving hemodialysis by Robert H. Spencer, Catherine Munera, Megan J. Shram, Frédérique Menzaghi

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Investigating the role of an immediate early gene FOS as a potential regulator of autophagic response to hypoglycemia in embryonic hypothalamic neurons by Rakhee K. Ramakrishnan, Ankita Srivastava, Reeja Rajan, Salah Abusnana, Bashair M. Mussa

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Fear and food: Anxiety‐like behavior and the susceptibility to weight loss in an activity‐based anorexia rat model by Constanze Schwenzer, Clara Voelz, Vanessa Kogel, Anna Schlösser, Beate Herpertz‐Dahlmann, Cordian Beyer, Jochen Seitz, Stefanie Trinh

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Developing a mechanistic understanding of the nonlinear pharmacokinetics of letermovir and prospective drug interaction with everolimus using physiological‐based pharmacokinetic mo... by Karsten Menzel, Yuhsin Kuo, Dapeng Chen, Georgy Hartmann, Ying‐Hong Wang, Carolyn R. Cho, Jacqueline B. McCrea, Kazuhiko Asari

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Development of an Integrated Platform Using Multidisciplinary Real‐World Data to Facilitate Biomarker Discovery for Medical Products by Stefan Dabic, Yasameen Azarbaijani, Tigran Karapetyan, Nilsa Loyo‐Berrios, Vahan Simonyan, Terrie Kitchner, Murray Brilliant, Yelizaveta Torosyan

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Pharmacokinetics, safety and tolerability of valbenazine in Korean CYP2D6 normal and intermediate metabolizers by Woo Kyung Chung, Inyoung Hwang, Byungwook Kim, Jihyun Jung, Kyung‐Sang Yu, In‐Jin Jang, Jaeseong Oh

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Primary Care Prescription Drug Use and Related Actionable Drug‐Gene Interactions in the Danish Population by Carin Adriana Theodora Catharina Lunenburg, Alexander Sebastian Hauser, Kazi Ishtiak‐Ahmed, Christiane Gasse

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Pharmacometric dose optimization of buprenorphine in neonatal opioid withdrawal syndrome by Rena Eudy‐Byrne, Nicole Zane, Susan C. Adeniyi‐Jones, Marc R. Gastonguay, Ana Ruiz‐Garcia, Gagan Kaushal, Walter K. Kraft

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Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling by Stephanie N. Liu, Priya Agarwal, Katja Heinig, Asim Datye, Carolina Sturm‐Pellanda, Andrea Crugnola, Marc Arca, Dale Miles

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Population pharmacokinetics of everolimus in adult liver transplant patients: Comparison to tacrolimus disposition and extrapolation to pediatrics by Kotaro Itohara, Ikuko Yano, Shunsaku Nakagawa, Mitsuhiro Sugimoto, Machiko Hirai, Atsushi Yonezawa, Satoshi Imai, Takayuki Nakagawa, Daiki Hira, Takashi Ito, Koichiro Hata, Etsuro Hatano, Tomohiro Terada, Kazuo Matsubara

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Concentration‐QTc modeling of sitravatinib in patients with advanced solid malignancies by Adam Dickinson, Yong Liu, Artem Uvarov, Thomas Peyret, J. F. Marier, Curtis Chin, Jonathan Q. Tran

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Exocrine Pancreatic Dysfunction Increases the Risk of New‐Onset Diabetes Mellitus: Results of a Nationwide Cohort Study by Jaelim Cho, Robert Scragg, Stephen J. Pandol, Maxim S. Petrov

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YH12852, a Potent and Selective Receptor Agonist of 5‐hydroxytryptamine, Increased Gastrointestinal Motility in Healthy Volunteers and Patients With Functional Constipation by Hyun A. Lee, Seol Ju Moon, Hyounggyoon Yoo, Mi Kyung Kim, Seong Bok Jang, Seoungoh Lee, Sohee Kim, Howard Lee

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A phase I study comparing the pharmacokinetics and safety of HS628 (tocilizumab biosimilar) and reference tocilizumab in healthy male subjects by Hongjie Qian, Jie Cheng, Yuzhou Gui, Wei Wang, Liyu Liang, Huijuan Zhu, Qingqing Wu, Meixian Ou, Qian Chen, Chen Yu, Jingying Jia

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