Search Results - "translational science"

Clinical pharmacokinetics of atropine oral gel formulation in healthy volunteers by Madison Parrot, Bhuvanesh Yathavan, Olga Averin, Logan Hoggard, Joseph E. Rower, Michael Voight, Danielle Greene, Ariel Tarrell, Aviva Whelan, Hamidreza Ghandehari, Nancy Murphy, Venkata Yellepeddi

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Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers by Xinwen Wang, Lucy Her, Jingcheng Xiao, Jian Shi, Audrey H. Wu, Barry E. Bleske, Hao‐Jie Zhu

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Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability. by Emily Peak, Iain W Chalmers, Karl F Hoffmann

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Imeglimin population pharmacokinetics and dose adjustment predictions for renal impairment in Japanese and Western patients with type 2 diabetes by Yoshiko Tomita, Emma Hansson, Florent Mazuir, Gustaf J Wellhagen, Qing Xi Ooi, Enrica Mezzalana, Atsushi Kitamura, Daisuke Nemoto, Sébastien Bolze

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Atorvastatin population pharmacokinetics in a real‐life setting: Influence of genetic polymorphisms and association with clinical response by Gabriel Stillemans, Adrien Paquot, Giulio G. Muccioli, Emilia Hoste, Nadtha Panin, Anders Åsberg, Jean‐Luc Balligand, Vincent Haufroid, Laure Elens

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Safety, pharmacokinetics, and food effect of sudapyridine (WX‐081), a novel anti‐tuberculosis candidate in healthy Chinese subjects by Chengyin Yu, Hongjie Qian, Qingqing Wu, Yang Zou, Qicheng Ding, Yuting Cai, Liyu Liang, Juncai Xu, Lei Li, Bin Zan, Yongguo Li, Yun Liu

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A first‐in‐human, single and multiple dose study of lunsekimig, a novel anti‐TSLP/anti‐IL‐13 NANOBODY® compound, in healthy volunteers by Annemie Deiteren, Lieselot Bontinck, Griet Conickx, Marie Vigan, Nele Dervaux, Matthieu Gassiot, Selcuk Bas, Benjamin Suratt, Heribert Staudinger, Emmanuel Krupka

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Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS‐441524 in patients with COVID‐19: A limited case series by Pyoeng Gyun Choe, Sae Im Jeong, Chang Kyung Kang, Liju Yang, SeungHwan Lee, Joo‐Youn Cho, Seung Seok Han, Dong Ki Kim, Sang Min Lee, Wan Beom Park, Myoung‐don Oh, Nam Joong Kim

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Model‐informed precision dosing of teicoplanin for the rapid achievement of the target area under the concentration‐time curve: A simulation study by Kazutaka Oda, Tomoyuki Yamada, Kazuaki Matsumoto, Yuki Hanai, Takashi Ueda, Masaru Samura, Akari Shigemi, Hirofumi Jono, Hideyuki Saito, Toshimi Kimura

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Data driven evaluation of healthy volunteer characteristics at screening for phase I clinical trials to inform on study design and optimize screening processes by Annemie Deiteren, Erwin Coenen, Sabine Lenders, Peter Verwilst, Erik Mannaert, Freya Rasschaert

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A Proposal of Conducting Bioequivalence Trials with Gastric pH Modulators for Two Oral Formulations Demonstrating Different Dissolution Profiles at Elevated pH by Hao Zhu, Xiaomei Chen, Mariam Ahmed, Yaning Wang, Qi Liu, Ramana S. Uppoor, Colleen Kuemmel, Mehul Mehta

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Predictability of human exposure by human‐CYP3A4‐transgenic mouse models: A meta‐analysis by David Damoiseaux, Alfred H. Schinkel, Jos H. Beijnen, Alwin D. R. Huitema, Thomas P. C. Dorlo

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Neutrophil elastase activates the release of extracellular traps from COPD blood monocyte‐derived macrophages by Shuo Zheng, Apparao B. Kummarapurugu, Gamze B. Bulut, Aamer Syed, Le Kang, Judith A. Voynow

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Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase by Jihyun Kang, Andrew HyoungJin Kim, Inseung Jeon, Jaeseong Oh, In‐Jin Jang, SeungHwan Lee, Joo‐Youn Cho

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Application of machine learning to predict reduction in total PANSS score and enrich enrollment in schizophrenia clinical trials by Jagdeep T. Podichetty, Rebecca M. Silvola, Violeta Rodriguez‐Romero, Richard F. Bergstrom, Majid Vakilynejad, Robert R. Bies, Robert E. Stratford Jr

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Pharmacokinetic interactions between fexuprazan, a potassium‐competitive acid blocker, and nonsteroidal anti‐inflammatory drugs in healthy males by Heejae Won, Eunwoo Kim, Jihye Chae, Hyejung Lee, Joo‐Youn Cho, In‐Jin Jang, Jae‐Yong Chung, Min‐Gul Kim, SeungHwan Lee

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Effects of sedative psychotropic drugs combined with oxycodone on respiratory depression in the rat by Lin Xu, Ashok Krishna, Sharron Stewart, Katherine Shea, Rebecca Racz, James L. Weaver, Donna A. Volpe, Nageswara R. Pilli, Suresh Narayanasamy, Jeffry Florian, Vikram Patel, Murali K. Matta, Marc B. Stone, Hao Zhu, Michael C. Davis, David G. Strauss, Rodney Rouse

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Evaluation of moxifloxacin in canine and non‐human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration‐QTc analysis by Ray W. Chui, Joel Baublits, Fiona A. Chandra, Zack W. Jones, Michael J. Engwall, Hugo M. Vargas

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Effects of 5‐HT₃ receptor antagonists on cisplatin‐induced kidney injury by Mitsuhiro Goda, Masaya Kanda, Toshihiko Yoshioka, Ami Yoshida, Yoichi Murai, Yoshito Zamami, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Masayuki Chuma, Yuki Izawa‐Ishizawa, Keisuke Ishizawa

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First‐in‐human study of milvexian, an oral, direct, small molecule factor XIa inhibitor by Vidya Perera, Zhaoqing Wang, Joseph Luettgen, Danshi Li, Mary DeSouza, Michael Cerra, Dietmar Seiffert

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