Search Results - "translational science"

Mevalonate in blood and muscle: Response to atorvastatin treatment and the relationship to statin intolerance in patients with coronary heart disease by Trine Lauritzen, John Munkhaugen, Stein Bergan, Elise Sverre, Kari Peersen, Sofia Lindahl, Einar Husebye, Nils Tore Vethe

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Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing by Amy J. Turner, Cyrine E. Haidar, Wenjian Yang, Erin C. Boone, Steven M. Offer, Philip E. Empey, Andrew Haddad, Saba Tahir, Gunter Scharer, Ulrich Broeckel, Andrea Gaedigk

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Effect of renal impairment on the pharmacokinetics and safety of dorzagliatin, a novel dual‐acting glucokinase activator by Jia Miao, Ping Fu, Shuang Ren, Chao Hu, Ying Wang, Chengfeng Jiao, Ping Li, Yu zhao, Cui Tang, Yuli Qian, Rong Yang, Yanli Dong, Jing Rong, Yaohui Wang, Xiaowei Jin, Yu Sun, Li Chen

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PF‐07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID‐19 patients by Raymond K. Hau, Stephen H. Wright, Nathan J. Cherrington

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Proton pump inhibitor use and risk of depression and anxiety in children: nationwide cohort study by Yun‐Han Wang, Viktor Wintzell, Jonas F. Ludvigsson, Henrik Svanström, Björn Pasternak

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Pharmacokinetics, safety, and simulated efficacy of an influenza treatment, baloxavir marboxil, in Chinese individuals by Yanmei Liu, Sylvie Retout, Vincent Duval, Jingying Jia, Yang Zou, Yijun Wang, Valérie Cosson, Sébastien Jolivet, Stefan De Buck

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Pharmacokinetics of asciminib in the presence of CYP3A or P‐gp inhibitors, CYP3A inducers, and acid‐reducing agents by Matthias Hoch, Felix Huth, Masahiko Sato, Tirtha Sengupta, Michelle Quinlan, Stephanie Dodd, Shruti Kapoor, Florence Hourcade‐Potelleret

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Evaluation of atezolizumab immunogenicity: Clinical pharmacology (part 1) by Benjamin Wu, Nitzan Sternheim, Priya Agarwal, Julia Suchomel, Shweta Vadhavkar, Rene Bruno, Marcus Ballinger, Coen A. Bernaards, Phyllis Chan, Jane Ruppel, Jin Jin, Sandhya Girish, Amita Joshi, Valerie Quarmby

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Study protocol: A comparison of mobile and clinic‐based spirometry for capturing the treatment effect in moderate asthma by Elena S. Izmailova, Rachel Kilian, Jessie P. Bakker, Shawna Evans, Anthony D. Scotina, Theodore F. Reiss, Dave Singh, John A. Wagner

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Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org by Zachary L. Taylor, Tamara P. Miller, Ethan A. Poweleit, Nicholas P. DeGroote, Lauren Pommert, Oluwafunbi Awoniyi, Sarah G. Board, Ngozi Ugboh, Vivek Joshi, Nick Ambrosino, Ashley Chavana, Melanie B. Bernhardt, Eric S. Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey

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Leukocyte cell‐derived chemotaxin 2 correlates with pediatric non‐alcoholic fatty liver disease by Diego Paine‐Cabrera, Lisa K. Harvey, Dakota R. Robarts, Michele T. Pritchard, John Thyfault, Steven A. Weinman, Udayan Apte, Voytek Slowik

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A 3‐week nonalcoholic steatohepatitis mouse model shows elafibranor benefits on hepatic inflammation and cell death by François Briand, Christophe Heymes, Lucile Bonada, Thibault Angles, Julie Charpentier, Maxime Branchereau, Emmanuel Brousseau, Marjolaine Quinsat, Nicolas Fazilleau, Rémy Burcelin, Thierry Sulpice

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The efficacy and safety of the short‐term combination therapy with ticagrelor and PPIs or H2RA in patients with acute STEMI who underwent emergency PCI by Peng Wei, Shujiang Zhuo, Qiang Fu, Haibo Wang, Bin Zong, Bangming Cao, Liansheng Wang

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Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial by Maja Arena Jørgensen, Karen Johanne Pallesen, Lone Overby Fjorback, Lise Juul

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First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator by Sebastiaan J. W. vanKraaij, Pim Gal, Laura G. J. M. Borghans, Erica S. Klaassen, Francis Dijkstra, Christopher Winrow, Chad Glasser, Geert Jan Groeneveld

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A Novel LC‐MS/MS Assay for Quantification of Des‐carboxy Prothrombin and Characterization of Warfarin‐Induced Changes by Abdul Basit, Bhagwat Prasad, Joanne K. Estergreen, Daniel E. Sabath, Nathan Alade, David L. Veenstra, Allan E. Rettie, Kenneth E. Thummel

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Pooled analysis of routine safety parameters observed in healthy participants at baseline and following placebo administration in early phase clinical studies by Kelly E. Duncan, Runcheng Li, Lata Maganti, Amit Kumar, S. Aubrey Stoch, Geoffrey A. Walford

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Evaluation of the abuse potential of difelikefalin, a selective kappa‐opioid receptor agonist, in recreational polydrug users by Megan J. Shram, Robert H. Spencer, Jenny Qian, Catherine L. Munera, Michael E. Lewis, Jack E. Henningfield, Lynn Webster, Frédérique Menzaghi

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Using Real‐World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic‐Pharmacodynamic Study by Shan Pan, Teresa Tsakok, Nick Dand, Dagan O. Lonsdale, Floris C. Loeff, Karien Bloem, Annick deVries, David Baudry, Michael Duckworth, Satveer Mahil, Angela Pushpa‐Rajah, Alice Russell, Ali Alsharqi, Gabrielle Becher, Ruth Murphy, Shyamal Wahie, Andrew Wright, Christopher E.M. Griffiths, Nick J. Reynolds, Jonathan Barker, Richard B. Warren, A. David Burden, Theo Rispens, Joseph F. Standing, Catherine H. Smith, on behalf of the BADBIR Study Group, the BSTOP Study Group, the PSORT Consortium

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Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe by Jonny Kinzi, Markus Grube, Isabell Seibert, Werner Siegmund, Henriette E. Meyer zu Schwabedissen

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