Search Results - "translational science"

Population pharmacokinetic and pharmacodynamic modeling of evobrutinib in healthy adult participants by Orestis Papasouliotis, David Mitchell, Pascal Girard, Martin Dyroff

Connect to this object online.

Approach to High Volume Enrollment in Clinical Research: Experiences from an All of Us Research Program Site by Titilayo O. Ilori, Emma Viera, Jillian Wilson, Francisco Moreno, Usha Menon, John Ehiri, Rachele Peterson, Tejo Vemulapalli, Sara C. StimsonRiahi, Cecilia Rosales, Elizabeth Calhoun, Amanda Sokan, Jason H. Karnes, Eric Reiman, Akinlolu Ojo, Andreas Theodorou, Tammy Ojo

Connect to this object online.

Effects of triclabendazole and its metabolite exposure on the heart‐rate-corrected QT intervals: A randomized, placebo‐ and positive‐controlled thorough QT study in healthy individ... by William T. Prince, Vinay Kumar Venishetty, Jean Lecot, Kasra Shakeri‐Nejad, Cathy Gray, Amanda Taylor, Ganesh R. Iyer, Julia Zack

Connect to this object online.

Explainable machine learning prediction of edema adverse events in patients treated with tepotinib by Federico Amato, Rainer Strotmann, Roberto Castello, Rolf Bruns, Vishal Ghori, Andreas Johne, Karin Berghoff, Karthik Venkatakrishnan, Nadia Terranova

Connect to this object online.

Pharmacokinetic drug-drug interactions of JBPOS0101 mediated by cytochrome P450 3A4 and UDP‐glucuronosyltransferases by Sejung Hwang, Yong Moon Choi, Myoung‐Seok Kim, SeungHwan Lee

Connect to this object online.

Association between betamethasone levels and respiratory distress syndrome in preterm births: A prospective cohort study by Noah Zafran, Manal Massalha, Abeer Suleiman, Refaat Massalha, Lila Mahagna, Scott A. Weiner, Shabtai Romano, Eliezer Shalev, Raed Salim

Connect to this object online.

Novel Bruton's Tyrosine Kinase inhibitor remibrutinib: Drug‐drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling by Felix Huth, Hilmar Schiller, Yi Jin, Birk Poller, Carole Schuhler, Wendy Weis, Ralph Woessner, Anton Drollmann, Peter End

Connect to this object online.

Inter‐ and Intrafamilial Phenotypic Variability in Individuals with Collagen‐Related Osteogenesis Imperfecta by Lidiia Zhytnik, Katre Maasalu, Tiia Reimand, Binh Ho Duy, Sulev Kõks, Aare Märtson

Connect to this object online.

Evaluation of the potential drug interactions mediated through P‐gp, OCT2, and MATE1/2K with filgotinib in healthy subjects by Chia‐Hsiang Hsueh, Kacey Anderson, Gong Shen, Chohee Yun, Ann Qin, Ahmed A. Othman

Connect to this object online.

From Invention to Innovation: Risk Analysis to Integrate One Health Technology in the Dairy Farm by Andrea Lombardo, Carlo Boselli, Simonetta Amatiste, Simone Ninci, Chiara Frazzoli, Roberto Dragone, Alberto De Rossi, Gerardo Grasso, Alberto Mantovani, Giovanni Brajon

Connect to this object online.

Ligustrazine alleviates pulmonary arterial hypertension in rats by promoting the formation of myocardin transcription complex in the nucleus of pulmonary artery smooth muscle cells by Xichao Yu, Mingjie Wu, Qinhai Meng, Weijie Zhu, Chenyan Zhang, Bowen Liu, Yuewen Qi, Shuqun Gu, Xinyu Wang, Jingli Wen, Yu Li, Xu Qi

Connect to this object online.

Target‐Mediated Drug Disposition Pharmacokinetic/Pharmacodynamic Model‐Informed Dose Selection for the First‐in‐Human Study of AVB‐S6‐500 by Laura Bonifacio, Michael Dodds, David Prohaska, Aaron Moss, Amato Giaccia, Ray Tabibiazar, Gail McIntyre

Connect to this object online.

Serious arrhythmia in initiators of citalopram, escitalopram, and other selective serotonin reuptake inhibitors: A population‐based cohort study in older adults by Mia Aakjær, Sarah Kimmer Werther, Marie Louise De Bruin, Morten Andersen

Connect to this object online.

Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium by Bianca D. vanGroen, Venkatesh Pilla Reddy, Justine Badée, Andrés Olivares‐Morales, Trevor N. Johnson, Johan Nicolaï, Pieter Annaert, Anne Smits, Saskia N. deWildt, Catherijne A. J. Knibbe, Loeckie deZwart

Connect to this object online.

Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers by Islam R. Younis, Brian J. Kirby, Andrew N. Billin, Deqing Xiao, Qinghua Song, Timothy R. Watkins, Ahmed A. Othman

Connect to this object online.

Human radiolabeled mass balance studies supporting the FDA approval of new drugs by Anuradha Ramamoorthy, Girish Bende, Edwin Chiu Yuen Chow, Hristina Dimova, Neil Hartman, Daphney Jean, Sonia Pahwa, Yunzhao Ren, Chinmay Shukla, Yuching Yang, Suresh Doddapaneni, Zhixia Yan Danielsen

Connect to this object online.

Population‐based cellular kinetic characterization of ciltacabtagene autoleucel in subjects with relapsed or refractory multiple myeloma by Liviawati S. Wu, Yaming Su, Claire Li, Wangda Zhou, Carolyn C. Jackson, Yu‐Nien Sun, Honghui Zhou

Connect to this object online.

Genistein‐Calcitriol Mitigates Hyperosmotic Stress‐Induced TonEBP, CFTR Dysfunction, VDR Degradation and Inflammation in Dry Eye Disease by Trailokyanath Panigrahi, Sharon D'Souza, Rohit Shetty, Archana Padmanabhan Nair, Anuprita Ghosh, Everette Jacob Remington Nelson, Arkasubhra Ghosh, Swaminathan Sethu

Connect to this object online.

Implementation of a pharmacogenetic panel‐based test for pharmacotherapy‐based supportive care in an adult oncology clinic by Emily J. Cicali, Elizabeth Eddy, Yan Gong, Amanda L. Elchynski, Kim Pena del Aguila, Tala Basha, Karen C. Daily, Lauren Dickson, Steven Fischer, Erin Hastings‐Monari, Dennie Jones Jr, Brian H. Ramnaraign, David L. DeRemer, Thomas J. George, Rhonda M. Cooper‐DeHoff

Connect to this object online.

Association of concomitant headache with hypoperfusion in ischemic stroke: A multimodal CT‐based study by Yi Ge, Wanli Dong, Haifeng Lu, Ximeng Zhang, Shicun Huang, Yi Yang, Jianqiang Ni

Connect to this object online.