Search Results - "translational science"

Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers by Shingen Misaka, Yuko Ono, Atsushi Uchida, Tomoyuki Ono, Osamu Abe, Hiroshi Ogata, Hideyuki Sato, Masahiko Suzuki, Satomi Onoue, Yayoi Shikama, Kenju Shimomura

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Continuous Monitoring Using a Wearable Device Detects Activity‐Induced Heart Rate Changes After Administration of Amphetamine by Elena S. Izmailova, Ian L. McLean, Greg Hather, David Merberg, Jason Homsy, Matthew Cantor, Dmitri Volfson, Gaurav Bhatia, Eric D. Perakslis, Christopher Benko, John A. Wagner

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The randomized, single‐ and multiple‐ ascending dose studies of the safety, tolerability, pharmacokinetics of CSPCHA115 in healthy Chinese subjects by Shan Jing, Wenfang Liu, Kexu Yang, Yang Lin, Xuekun Yao, Guilan Sun

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In vitro safety "clinical trial" of the cardiac liability of drug polytherapy by Bérénice Charrez, Verena Charwat, Brian Siemons, Henrik Finsberg, Evan W. Miller, Andrew G. Edwards, Kevin E. Healy

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Impact of posaconazole and diltiazem on pharmacokinetics of encorafenib, a BRAF V600 kinase inhibitor for melanoma and colorectal cancer with BRAF mutations by Erik Hahn, Renae Chavira, Lance Wollenberg, Weiwei Tan, Micaela B. Reddy

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Sarcopenia assessed by computed tomography or magnetic resonance imaging is associated with the loss of response to biologic therapies in adult patients with Crohn's disease by Jingjing Liu, Hongye Tang, Tingting Lin, Jiangchuan Wang, Wenjing Cui, Chao Xie, Zhongqiu Wang, Yugen Chen, Xiao Chen

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Pharmacokinetics and Pharmacodynamics of Cenerimod, A Selective S1P1R Modulator, Are Not Affected by Ethnicity in Healthy Asian and White Subjects by Pierre‐Eric Juif, Jasper Dingemanse, Peter Winkle, Mike Ufer

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Pharmacokinetic equations versus Bayesian guided vancomycin monitoring: Pharmacokinetic model and model‐informed precision dosing trial simulations by Abdullah Aljutayli, Daniel J. G. Thirion, Guillaume Bonnefois, Fahima Nekka

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Variability of Dosing and Number of Medications Needed to Achieve Adequate Sedation in Mechanically Ventilated Pediatric Intensive Care Patients by Emma M. Tillman, Joseph Ipe, Kelly J. Weaver, Todd C. Skaar, Courtney M. Rowan, James E. Slaven

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A Single and Multiple Ascending Dose Study of Toll‐Like Receptor 7 Agonist (RO7020531) in Chinese Healthy Volunteers by Andrea Luk, Qiudi Jiang, Katerina Glavini, Miriam Triyatni, Na Zhao, Tomas Racek, Yonghong Zhu, Joseph F. Grippo

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Identification of peripheral vascular function measures and circulating biomarkers of mitochondrial function in patients with mitochondrial disease by Sebastiaan J. W. vanKraaij, Diana R. Pereira, Bastiaan Smal, Luciana Summo, Anne Konkel, Janine Lossie, Andreas Busjahn, Tom N. Grammatopoulos, Erica Klaassen, Robert Fischer, Wolf‐Hagen Schunck, Pim Gal, Matthijs Moerland

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Readiness to Change and Prospective Effects of Weight Management Programs in Pediatric Nonalcoholic Fatty Liver Disease by Voytek Slowik, Heather Wasserkrug, Ryan T. Fischer, Mark Connelly, Amanda D. Deacy, Sarah Hampl, James F. Daniel

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Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution by Marie Lenski, Jonathan Sidibé, Mehdi Gholam, Benjamin Hennart, Céline Dubath, Marc Augsburger, Armin vonGunten, Philippe Conus, Delphine Allorge, Aurelien Thomas, Chin B. Eap

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Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling by Daniela Hofmann, Cornelis Smit, Somphou Sayasone, Marc Pfister, Jennifer Keiser

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Comparing, Contrasting, and Integrating Dissemination and Implementation Outcomes Included in the RE-AIM and Implementation Outcomes Frameworks by Kathryn Louise Reilly, Sarah Kennedy, Gwenndolyn Porter, Paul Estabrooks

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Risk factors for hyperglycemia in COVID‐19 patients treated with remdesivir by Woorim Kim, Go Woon Lee, Nuga Rhee, Kyung Hyun Min, Jun Hyeob Kim, Jin Yeon Gil, Song Yi Kim, Ji Min Han, Kyung Eun Lee

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Effects on the Ocular Surface from Reading on Different Smartphone Screens: A Prospective Randomized Controlled Study by Kelan Yuan, Haiping Zhu, Yujie Mou, Yaying Wu, Jingliang He, Xiaodan Huang, Xiuming Jin

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Pharmacogenomic studies of fertility outcomes in pediatric cancer survivors - A systematic review by Tayla Stenta, Michael Assis, Katie Ayers, Elena J. Tucker, Andreas Halman, Debra Gook, Andrew H. Sinclair, David A. Elliott, Yasmin Jayasinghe, Rachel Conyers

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Glucocorticoids mediate transcriptome‐wide alternative polyadenylation: Potential mechanistic and clinical implications by Thanh Thanh L. Nguyen, Duan Liu, Huanyao Gao, Zhenqing Ye, Jeong‐Heon Lee, Lixuan Wei, Jia Yu, Lingxin Zhang, Liewei Wang, Tamas Ordog, Richard M. Weinshilboum

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Comprehensive in vitro pro‐arrhythmic assays demonstrate that omecamtiv mecarbil has low pro‐arrhythmic risk by Yusheng Qu, BaoXi Gao, Ziva Arimura, Mei Fang, Hugo M. Vargas

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