Search Results - "translational science"

Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers by Tianxing Liu, Kensei Hashizume, Eva Krieg, Huijun Chen, Yuki Mukaida, Kirstin Thelen, Frauke Friedrichs, Stefan Willmann, Stephan Schwers, Alexander Solms, Rosie Yu

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Pharmacogenomics guided versus standard antidepressant treatment in a community pharmacy setting: A randomized controlled trial by John Papastergiou, Lena C. Quilty, Wilson Li, Thulasi Thiruchselvam, Esha Jain, Peter Gove, Leilany Mandlsohn, Bart vanden Bemt, Nedzad Pojskic

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Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis by Melanie R. Nicol, Katelyn A. Pastick, Joneé Taylor, Olivie C. Namuju, Joshua Rhein, Darlisha A. Williams, David B. Meya, David R. Boulware, Robert Lukande

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Safety, tolerability, and pharmacokinetics of single and multiple topical ophthalmic administration of imatinib mesylate in healthy subjects by Joo Young Na, Ki Young Huh, Kyung‐Sang Yu, Joon Young Hyon, Hye Cheong Koo, Jong Ho Lee, Ji Chang You, Jae‐Yong Chung

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Lay understandings of drug‐gene interactions: The right medication, the right dose, at the right time, but what are the right words? by Karen M. Meagher, Kelsey Stuttgen Finn, Susan H. Curtis, Jack Borucki, Annika T. Beck, Amal W. Cheema, Richard R. Sharp

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Methodological quality of network meta-analysis in dentistry: a meta-research by Anelise Fernandes MONTAGNER, Patricia Daniela Melchiors ANGST, Daniela Prócida RAGGIO, Françoise Helène VAN DE SANDE, Tamara Kerber TEDESCO

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The presence of busulfan metabolites and pharmacometabolomics in plasma drawn immediately before allograft infusion in hematopoietic cell transplant recipients by Jeannine S. McCune, Sandi L. Navarro, Linda J. Risler, Brian R. Phillips, Suping Ren, H. Gary Schoch, K. Scott Baker

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Evaluation of the potential for pharmacokinetic interaction between tirabrutinib and levonorgestrel/ethinyl estradiol in healthy female volunteers by Ganesh Cherala, Cara Nelson, Ying Guo, Anubhav Mathur, Thomas Tarnowski, Ahmed A. Othman

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Advancing clinical development for neuronopathic Hunter syndrome through a quantitatively‐driven reverse translation framework by Robert D. Latzman, Olivia Campagne, Meera E. Modi, Marta Karas, C. J. Malanga, David A. H. Whiteman

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Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist by Yan Xu, Xin Miao, Paulien Ravenstijn, Anja Hijzen, Mark E. Schmidt, Partha Nandy, Honghui Zhou

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Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABAA Neurotransmission and the Nitric Oxide Pathway by Helia Aghamiri, Hamed Shafaroodi, Jinous Asgarpanah

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Evaluation of population‐level pharmacogenetic actionability in Alabama by Brittney H. Davis, Kelly Williams, Devin Absher, Bruce Korf, Nita A. Limdi

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Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta‐Analysis by Da‐Peng Wang, Kai Kang, Qi Lin, Jian Hai

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Population Pharmacokinetics of Remimazolam in Procedural Sedation With Nonhomogeneously Mixed Arterial and Venous Concentrations by Jie Zhou, Laura Curd, Lauren L. Lohmer, Joachim Ossig, Frank Schippers, Thomas Stoehr, Virginia Schmith

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Genomewide association analysis of warfarin dose requirements in Middle Eastern and North African populations by Nihal El Rouby, Mohamed H. Shahin, Loulia Bader, Sherief I. Khalifa, Hazem Elewa

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Tissue‐ and cell‐expression of druggable host proteins provide insights into repurposing drugs for COVID‐19 by Jiapeng Li, Yanling Xue, Xinwen Wang, Logan S. Smith, Bing He, Shuhan Liu, Hao‐Jie Zhu

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Asia‐inclusive drug development leveraging principles of ICH E5 and E17 guidelines: Case studies illustrating quantitative clinical pharmacology as a foundational enabler by Hong Lu, Lena Klopp‐Schulze, Jatinder Kaur Mukker, Dandan Li, Yoshihiro Kuroki, Jayaprakasam Bolleddula, Nadia Terranova, Kosalaram Goteti, Wei Gao, Rainer Strotmann, Jennifer Dong, Karthik Venkatakrishnan

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Implications of Polymorphisms in the BCKDK and GATA‐4 Gene Regions on Stable Warfarin Dose in African Americans by Salma A. Bargal, Jennifer N. Kight, Felipe Augusto de Oliveira, Mohamed H. Shahin, Taimour Langaee, Yan Gong, Issam S. Hamadeh, Rhonda M. Cooper-DeHoff, Larisa H. Cavallari

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Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units by Paloma Moraga, Paula Prieto, Almari Conradie, Majda Benhayoun, Vicki Rousell, Maria Davy, Uwe Fuhr, Rosa Antonijoan Arbos, Francisco Abad‐Santos, Antonio Portolés, Jolanda Van Duinen, Antonio J. Carcas, Alberto M. Borobia, the ERA4TB Consortium

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Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers by Benny M. Amore, Clay T. Cramer, Diane E. MacDougall, William J. Sasiela, Maurice G. Emery

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