Search Results - "translational science"

The motivation and process for developing a consortium‐wide time and motion study to estimate resource implications of innovations in the use of genome sequencing to inform patient... by Hannah G. Hoban, Tiffany A. Yip, Joanna C. Chau, Jeannette T. Bensen, Lauren R. Desrosiers, Candice R. Finnila, Lucia A. Hindorff, Nicole R. Kelly, Frances L. Lynch, Bradley A. Rolf, Hadley S. Smith, Melissa P. Wasserstein, Kristen Hassmiller Lich

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A decade comparison of regulatory decision patterns for oncology products to all other non‐oncology products among Swissmedic, European Medicines Agency, and US Food and Drug Admin... by Ulrich‐P. Rohr, Mario Iovino, Leonie Rudofsky, Qiyu Li, Stephanie Juritz, Arunas Gircys, Oliver Wildner, Magda Bujar, Claus Bolte, Simon Dalla Torre di Sanguinetto, Anita Wolfer

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Ascites affects the benefit of carvedilol on patients with liver cirrhosis and esophageal and gastric varices by Ruiqi Xia, Bing Wu, Ji Zhou, Mingyan Ji, Shuyue Wang, Xiaoqing Zeng, Shiyao Chen

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Reimbursement Lag of New Drugs Under Taiwan's National Health Insurance System Compared With United Kingdom, Canada, Australia, Japan, and South Korea by Yi‐Ru Shih, Kai‐Hsin Liao, Yen‐Hui Chen, Fang‐Ju Lin, Fei‐Yuan Hsiao

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Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis by Kai Xue, Jinfeng Cao, Yinan Wang, Xue Zhao, Dan Yu, Chunshun Jin, Chengbi Xu

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Effect of discontinuation of lemborexant following long‐term treatment of insomnia disorder: Secondary analysis of a randomized clinical trial by Yoshikazu Takaesu, Masahiro Suzuki, Margaret Moline, Kate Pinner, Kanako Inabe, Yurie Nishi, Kenichi Kuriyama

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Preoperative medication use and development of postoperative delirium and cognitive dysfunction by Maria Heinrich, Anja Nottbrock, Friedrich Borchers, Rudolf Mörgeli, Jochen Kruppa, Georg Winterer, Arjen J. C. Slooter, Claudia Spies, the BioCog Consortium

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Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine by Barthelemy Diouf, Claudia Wing, John C. Panetta, Donnie Eddins, Wenwei Lin, Wenjian Yang, Yiping Fan, Deqing Pei, Cheng Cheng, Shannon M. Delaney, Wei Zhang, Erik J. Bonten, Kristine R. Crews, Steven W. Paugh, Lie Li, Burgess B. Freeman 3rd, Robert J. Autry, Jordan A. Beard, Daniel C. Ferguson, Laura J. Janke, Kirsten K. Ness, Taosheng Chen, Stanislav S. Zakharenko, Sima Jeha, Ching‐Hon Pui, Mary V. Relling, M. Eileen Dolan, William E. Evans

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A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody MK‐1654 in healthy Japanese adults by Yuji Orito, Naoyuki Otani, Yuki Matsumoto, Katsukuni Fujimoto, Nobuyuki Oshima, Brian M. Maas, Luzelena Caro, Antonios O. Aliprantis, Kara S. Cox, Osamu Tokumaru, Masaaki Kodama, Hideo Kudo, Hiromitsu Imai, Naoto Uemura

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Mass balance and pharmacokinetic characterization of zavegepant in healthy male subjects by Rajinder Bhardwaj, Mary Donohue, Jennifer Madonia, Matt S. Anderson, Kyle Matschke, Richard Bertz, Robert Croop, Jing Liu

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QPGx‐CARES: Qatar pharmacogenetics clinical applications and research enhancement strategies by Rania Abdel‐latif, Radja Badji, Shaban Mohammed, Wadha Al‐Muftah, Hamdi Mbarek, Dima Darwish, Duha Assaf, Daoud Al‐Badriyeh, Hazem Elewa, Nahla Afifi, Naseer Ahmad Masoodi, Amr Salah Omar, Jassim Al Suwaidi, Salha Bujassoum, Moza Al Hail, Said I. Ismail, Asma Althani

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Mapping Australian pharmacy school curricula for content related to pharmacogenomics by Maija-Liisa Venugopal, Faith R. Yong, Natalia Krzyzaniak, Adam La Caze, Christopher Freeman

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Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method by Ryo Nakamura, Takashi Yoshikado, Yasunori Aoki, Yuichi Sugiyama, Koji Chiba

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A case study of a patient‐centered reverse translational systems‐based approach to understand adverse event profiles in drug development by Sarah Kim, Gezim Lahu, Majid Vakilynejad, Theodoros G. Soldatos, David B. Jackson, Lawrence J. Lesko, Mirjam N. Trame

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Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of the P2Y12 receptor antagonist selatogrel by Uta Schilling, Chih‐Hsuan Hsin, Stephane Delahaye, Andreas Krause, Hauke Wuelfrath, Atef Halabi, Jasper Dingemanse

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Model‐based assessments of CYP3A‐mediated drug‐drug interaction risk of milademetan by Ying Hong, Tomoko Ishizuka, Akiko Watanabe, Masaya Tachibana, Mark Lee, Hitoshi Ishizuka, Frank LaCreta, Malaz Abutarif

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Impact of Disease and Treatment Response in Drug-Drug Interaction Studies: Osimertinib and Simvastatin in Advanced Non‐Small Cell Lung Cancer by Karthick Vishwanathan, Mireille Cantarini, Karen So, Eric Masson, Jennifer Fetterolf, Suresh S. Ramalingam, R. Donald Harvey

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Model‐informed precision dosing of vancomycin for rapid achievement of target area under the concentration‐time curve: A simulation study by Kazutaka Oda, Tomoyuki Yamada, Kazuaki Matsumoto, Yuki Hanai, Takashi Ueda, Masaru Samura, Akari Shigemi, Hirofumi Jono, Hideyuki Saito, Toshimi Kimura

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Predicting completion of clinical trials in pregnant women: Cox proportional hazard and neural network models by Bomee Kim, Yun Ji Jang, Hae Ram Cho, So Yeon Kim, Ji Eun Jeong, Mi Kyoung Shim, Myeong Gyu Kim

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Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering by Paul R. Stabach, Kristin Zimmerman, Aaron Adame, Dillon Kavanagh, Christopher T. Saeui, Christian Agatemor, Shawn Gray, Wenxiang Cao, Enrique M. De La Cruz, Kevin J. Yarema, Demetrios T. Braddock

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