Search Results - "translational science"

Assessment of Target Engagement in a First‐in‐Human Trial with Sinbaglustat, an Iminosugar to Treat Lysosomal Storage Disorders by Martine Gehin, Meggane Melchior, Richard W.D. Welford, Patricia N. Sidharta, Jasper Dingemanse

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A pharmacokinetic study comparing the biosimilar HEC14028 and Dulaglutide (Trulicity®) in healthy Chinese subjects by Xianglei Gao, Yujing Di, Yuan Lv, Yingcai Luan, Yang Xiong, Yuli Xu, Yusheng Li, Linfeng Guo, Xiaoping Li, Li Deng, Yulei Zhuang, Jie Hou

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Screening and characterization of myositis‐related autoantibodies in COVID‐19 patients by Kai‐Fa Teo, Der‐Yuan Chen, Jeh‐Ting Hsu, Yi‐Hua Lai, Ching‐Kun Chang, Po‐Ren Hsueh, Joung‐Liang Lan, Jye‐Lin Hsu

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Protective effect of clusterin against interleukin‐1β‐induced apoptosis and inflammation in human knee osteoarthritis chondrocytes by Tachatra Ungsudechachai, Jiraphun Jittikoon, Sittisak Honsawek, Wanvisa Udomsinprasert

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Peppermint oil effects on the gut microbiome in children with functional abdominal pain by Santosh Thapa, Ruth Ann Luna, Bruno P. Chumpitazi, Numan Oezguen, Susan M. Abdel‐Rahman, Uttam Garg, Salma Musaad, James Versalovic, Gregory L. Kearns, Robert J. Shulman

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Use cases of registry‐based randomized controlled trials-A review of the registries' contributions and constraints by Nadine Kubesch, Sneha Gaitonde, Uarda Petriti, Elisabeth Bakker, Swati Basu, Laura Ellen Birks, Elodie Aubrun, Sieta T. de Vries, Rahel Schneider

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PK/PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development by Laura Oggianu, Beatrice Garrone, Francesco Fiorentini, Francesca Del Bene, Maria Teresa Rosignoli, Francesco Paolo Di Giorgio, Rafal Marian Kaminski

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Precision medicine in regulatory decision making: Biomarkers used for patient selection in European Public Assessment Reports from 2018 to 2020 by Elisabeth Bakker, Viktoriia Starokozhko, Jet W. M. Kraaijvanger, Hiddo J. L. Heerspink, Peter G. M. Mol

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The safety and tolerability of levodopa eye drops for the treatment of ocular disorders: A randomized first‐in‐human study by Kate Thomson, Cindy Karouta, Faran Sabeti, Nicola Anstice, Myra Leung, Tina Jong, Ted Maddess, Ian G. Morgan, Jeremy Game, Regan Ashby

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Population and Noncompartmental Pharmacokinetics of Sodium Oxybate Support Weight‐Based Dosing in Children and Adolescents With Narcolepsy With Cataplexy by Cuiping Chen, Carol L. Rosen, Chad Ruoff, Leslie H. Boyce, Rupa Parvataneni, Katie Zomorodi, Scott Brantley, Mark Sale, Giuseppe Plazzi

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A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID‐19 by Junsaku Kitagawa, Hayato Arai, Hiroyuki Iida, Jiro Mukai, Kenji Furukawa, Seitaro Ohtsu, Susumu Nakade, Tomohiro Hikima, Miwa Haranaka, Naoto Uemura

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Efficacy and safety of adamgammadex for reversing rocuronium‐induced deep neuromuscular blockade: A multicenter, randomized, phase IIb study by Yanhua Zhao, Sifan Chen, Wenqin Xie, Xiaoqing Zhang, Guozhong Chen, Fuhai Ji, Dongxin Wang, Youmao Qi, Qing Jie, Diansan Su, Weifeng Yu

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Analysis of GABRG2 C588T polymorphism in genetic epilepsy and evaluation of GABRG2 in drug treatment by Shitao Wang, Xianjun Zhang, Liang Zhou, Qian Wu, Yanbing Han

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Subtyping treatment response of tirofiban in acute ischemic stroke based on neuroimaging features by Bin Han, Xu Man, Jian Ding, Yuzhu Li, Xintao Tian, Xuelian Zhu, Jiang Yu, Jinping Sun

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A risk scoring system integrating postoperative factors for predicting early mortality after major non‐cardiac surgery by Dongwoo Chae, Na Young Kim, Hyun Joo Kim, Tae Lim Kim, Su Jeong Kang, So Yeon Kim

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Pharmacokinetic/pharmacodynamic modeling for dose selection for the first‐in‐human trial of the activated Factor XII inhibitor garadacimab (CSL312) by Dipti Pawaskar, Xi Chen, Fiona Glassman, Frauke May, Anthony Roberts, Mark Biondo, Andrew McKenzie, Marc W. Nolte, William J. Jusko, Michael Tortorici

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A phase I trial assessing the safety, pharmacokinetics, cerebrospinal fluid penetrance, and food effect of BTK inhibitor tolebrutinib in healthy volunteers by Marie‐José Cabanis, Olivier Nicolas, Olivier Vitse, Christelle Jan, Priscilla Brun, Patrick Soubayrol, William B. Smith, Timothy J. Turner, Emmanuel Krupka

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Aminobenzotriazole inhibits and induces several key drug metabolizing enzymes complicating its utility as a pan CYP inhibitor for reaction phenotyping by Krishna C. Aluri, Marina Slavsky, Ying Tan, Andrea Whitcher‐Johnstone, Zhoupeng Zhang, Niresh Hariparsad, Diane Ramsden

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Angiotensin 1‐7 protects against ventilator‐induced diaphragm dysfunction by Toshinori Yoshihara, Rafael Deminice, Hayden W. Hyatt, Mustafa Ozdemir, Branden L. Nguyen, Scott K. Powers

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Within‐individual reproducibility of a dual sample oral cholate challenge test (DuO) and simplified versions of the HepQuant SHUNT test by Michael P. McRae, John Kittelson, Steve M. Helmke, Gregory T. Everson

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