Search Results - "translational science"

A phase I randomized, double‐blind, single subcutaneous dose escalation study to determine the safety, tolerability, and pharmacokinetics of rezafungin in healthy adult subjects by Kenan Gu, Dennis Ruff, Cassandra Key, Marissa Thompson, Shoshanna Jiang, Taylor Sandison, Shawn Flanagan

Connect to this object online.

Single‐dose of LC51‐0255, a selective S1P1 receptor modulator, showed dose‐dependent and reversible reduction of absolute lymphocyte count in humans by Sang Won Lee, Inyoung Hwang, Jaeseong Oh, SeungHwan Lee, In‐Jin Jang, Kyung‐Sang Yu

Connect to this object online.

Developing a clinical research infrastructure embedded in an academic medicine center that equitably supports future clinician scientists by Maija Holsti, Heather T. Keenan, Howard A. Kadish, Heather K. Sapiro, Angelo P. Giardino, Katharine A. Osborn, Kristen L. Cline, Carrie L. Byington

Connect to this object online.

Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers by Kosuke Yoshida, Yuki Doi, Norihiko Iwazaki, Hidenori Yasuhara, Yuka Ikenaga, Hidetoshi Shimizu, Tomohisa Nakada, Tomoko Watanabe, Chise Tateno, Seigo Sanoh, Yaichiro Kotake

Connect to this object online.

Patients with geographic barriers to health care access are prescribed a higher proportion of drugs with pharmacogenetic testing guidelines by Rachel Dalton, Joshua D. Brown, Julio D. Duarte

Connect to this object online.

Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study by John C. Panetta, Olivia Campagne, Jessica Gartrell, Wayne Furman, Clinton F. Stewart

Connect to this object online.

Remimazolam versus propofol in combination with esketamine for surgical abortion: A double‐blind randomized controlled trial by Linli Yue, Xiaoling Ma, Na Li, Jing Chen, Jun Wang, Zhenzhen Wan, Lin Yang

Connect to this object online.

The association of CYP2C19 LoF alleles with adverse clinical outcomes in stroke patients taking clopidogrel: An updated meta‐analysis by Mohitosh Biswas, Md. Shahadat Hossain, Tahsin Ahmed Rupok, Md. Sabbir Hossain, Chonlaphat Sukasem

Connect to this object online.

Mortality, viral clearance, and other clinical outcomes of hydroxychloroquine in COVID‐19 patients: A systematic review and meta‐analysis of randomized controlled trials by Zakariya Kashour, Tarek Kashour, Danielle Gerberi, Imad M. Tleyjeh

Connect to this object online.

A randomized, single‐dose, crossover study of the effects of ulotaront on electrocardiogram intervals in subjects with schizophrenia by Hironobu Tsukada, Snezana M. Milanovic, Borje Darpo, Hongqi Xue, Kuangnan Xiong, Emily Tripp, Lisa Lennek, MaryAlice Worden, Seth C. Hopkins, Gerald R. Galluppi

Connect to this object online.

No drug-drug interactions between selective prolyl‐tRNA synthetase inhibitor, bersiporocin, and pirfenidone or nintedanib in healthy participants by Wonsuk Shin, Min Young Park, Jongwoo Kim, Jihyeon Kim, Jun Hee Nam, Jongwon Choi, A‐Young Yang, Hyounggyoon Yoo, Yil‐Seob Lee, Anhye Kim

Connect to this object online.

A systematic review of micro‐RNAs in aortic stenosis and cardiac fibrosis by Jemima Osekafore Adewuyi, Roshan Patel, Riccardo Abbasciano, Gerry P. McCann, Gavin Murphy, Marcin J. Woźniak, Anvesha Singh

Connect to this object online.

Synergy between health technology assessments and clinical guidelines for multiple sclerosis by Milou A. Hogervorst, Rick A. Vreman, Anna Zawada, Magdalena Zielińska, Dalia M. Dawoud, Brigit A. deJong, Aukje K. Mantel‐Teeuwisse, Wim G. Goettsch

Connect to this object online.

Pharmacokinetics/pharmacodynamics of L‐ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes by Rifaat Safadi, Robert S. Rahimi, Dominique Thabut, Jasmohan S. Bajaj, Kalyan Ram Bhamidimarri, Nikolaos Pyrsopoulos, Amy Potthoff, Stan Bukofzer, Laurene Wang, Khurram Jamil, Krishna R. Devarakonda

Connect to this object online.

The National Heart, Lung, and Blood Institute‐funded Production Assistance for Cellular Therapies (PACT) program: Eighteen years of cell therapy by Ashraf El Fiky, Laarni Ibenana, Robert Anderson, Joshua M. Hare, Aisha Khan, Adrian P. Gee, Cliona Rooney, David H. McKenna, Joseph Gold, Linda Kelley, Martha S. Lundberg, Lisbeth A. Welniak, Robert Lindblad

Connect to this object online.

Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications by Lindsey Ingleby‐Talecki, Sven C. vanDijkman, Sean P. Oosterholt, Oscar Della Pasqua, Christina Winter, Marianne Cunnington, Linda Rebar, Sergio Forero‐Schwanhaeuser, Vickas Patel, James A. Cooper, Anthony Bahinski, Khuram W. Chaudhary

Connect to this object online.

ST2 and CSF‐1 as potential druggable targets of inflammatory bowel diseases: Results from two‐sample Mendelian randomization study by Jiarui Mi, Xia Wu, Xiaoyin Bai, Yang Yang, Hong Yang

Connect to this object online.

Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Nav1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects by Pieter Siebenga, Guido vanAmerongen, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman, Richard Butt, Geert Jan Groeneveld

Connect to this object online.

Pharmacokinetic/LDL‐C and exposure-response analysis of tafolecimab in Chinese hypercholesterolemia patients: Results from phase I, II, and III studies by Shuling Yan, Xia Zhao, Qiushi Xie, Weijuan Du, Qingyang Ma, Tongkang Zhu, Huan Deng, Lei Qian, Shirui Zheng, Yimin Cui

Connect to this object online.

Upadacitinib pharmacokinetics and exposure‐response analyses of efficacy and safety in psoriatic arthritis patients - Analyses of phase III clinical trials by Elena Muensterman, Benjamin Engelhardt, Sathej Gopalakrishnan, Jaclyn K. Anderson, Mohamed‐Eslam F. Mohamed

Connect to this object online.