Search Results - "translational science"

Evaluation of the cytochrome P450 2C19 and 3A4 inhibition potential of the complement factor 5a receptor 1 antagonist ACT‐1014‐6470 in vitro and in vivo by Marion Anliker‐Ort, Jasper Dingemanse, Stephane Delahaye, Luboš Janů, John van denAnker, Benjamin Berger, Priska Kaufmann

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Intradermal substance P as a challenge agent in healthy individuals by Wouter tenVoorde, Chika Akinseye, Ismahaan Abdisalaam, Selinde Wind, Naomi Klarenbeek, Menthe Bergmans, Martijn vanDoorn, Robert Rissmann, Rejbinder Kaur, Sarah Hotee, Katie Foster, Arati Nair, Lea Fortunato, Colin Macphee, Sarah Mole, Katrine Baumann, Richard Brigandi

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Evaluation of drug-drug interactions of a novel potent FLT3 inhibitor SKLB1028 in healthy subjects by Jingcheng Chen, Jingxuan Wu, Nini Guo, Yuqin Song, Lijun Li, Bingyan Wang, Jiangshuo Li, Mengyu Hou, Hang Yin, Meijuan Zhang, Yanhong Kong, Xiaofang Wu, Ran Li, Le Wu, Qiannan Gao, Ruihua Dong

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Prediction of Human Pharmacokinetics of Antibody-Drug Conjugates From Nonclinical Data by Chunze Li, Cindy Zhang, Rong Deng, Douglas Leipold, Dongwei Li, Brandon Latifi, Yuying Gao, Crystal Zhang, Zao Li, Dale Miles, Shang‐Chiung Chen, Divya Samineni, Bei Wang, Priya Agarwal, Dan Lu, Saileta Prabhu, Sandhya Girish, Amrita V. Kamath

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Dose selection for intracerebroventricular cerliponase alfa in children with CLN2 disease, translation from animal to human in a rare genetic disease by Kevin Hammon, Greg deHart, Brian R. Vuillemenot, Derek Kennedy, Don Musson, Charles A. O'Neill, Martin L. Katz, Joshua W. Henshaw

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Comprehensive analysis of clinical and biological features in Parkinson's disease associated with the LRRK2 G2019S mutation: Data from the PPMI study by Xiaohui Sun, Kaixin Dou, Li Xue, Yijie Xie, Yong Yang, Anmu Xie

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COVID‐19 vaccine hesitancy: Race/ethnicity, trust, and fear by Don E. Willis, Jennifer A. Andersen, Keneshia Bryant‐Moore, James P. Selig, Christopher R. Long, Holly C. Felix, Geoffrey M. Curran, Pearl A. McElfish

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Tyrosine Kinase Inhibitors Reduce Glucose Uptake by Binding to an Exofacial Site on hGLUT‐1: Influence on 18F‐FDG PET Uptake by Vijaya L. Damaraju, Maral Aminpour, Michelle Kuzma, Philip Winter, Jordane Preto, Jack Tuszynski, Alexander B.J. McEwan, Michael B. Sawyer

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Pharmacokinetics and pharmacodynamics of cannabis‐based medicine in a patient population included in a randomized, placebo‐controlled, clinical trial by Julie Schjødtz Hansen, Fernando Boix, Jørgen Bo Hasselstrøm, Lambert Kristiansen Sørensen, Mads Kjolby, Stefan Gustavsen, Rikke Middelhede Hansen, Thor Petersen, Finn Sellebjerg, Helge Kasch, Peter Vestergaard Rasmussen, Nanna Brix Finnerup, Eva Aggerholm Sædder, Kristina Bacher Svendsen

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The effect of itraconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics of the first‐in‐class ACKR3/CXCR7 antagonist, ACT‐1004‐1239 by Christine Huynh, Jasper Dingemanse, Henriette E. Meyer zu Schwabedissen, Marlene Fonseca, Patricia N. Sidharta

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Genomic Association Analysis Reveals Variants Associated With Blood Pressure Response to Beta‐Blockers in European Americans by Sonal Singh, Nihal El Rouby, Caitrin W. McDonough, Yan Gong, Kent R. Bailey, Eric Boerwinkle, Arlene B. Chapman, John G. Gums, Stephen T. Turner, Rhonda M. Cooper‐DeHoff, Julie A. Johnson

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Assessment of clinical data on urocortins and their therapeutic potential in cardiovascular diseases: A systematic review and meta‐analysis by Dóra K. Kovács, Nelli Farkas, Alexandra Soós, Péter Hegyi, Leonardo Kelava, Szimonetta Eitmann, Anna Schekk, Zsolt Molnár, Bálint Erőss, Márta Balaskó

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Determination of a clinically effective evobrutinib dose: Exposure-response analyses of a phase II relapsing multiple sclerosis study by Orestis Papasouliotis, David Mitchell, Pascal Girard, Fernando Dangond, Martin Dyroff

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of HBM9161, a novel FcRn inhibitor, in a phase I study for healthy Chinese volunteers by Desmond Y. H. Yap, Jojo Hai, Paul C. H. Lee, Xueying Zhou, Michael Lee, Yu Zhang, Meng Wang, Xiaoxiang Chen

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Drug-drug interaction prediction of ziritaxestat using a physiologically based enzyme and transporter pharmacokinetic network interaction model by Jeremy Perrier, Virginie Gualano, Eric Helmer, Florence Namour, Viera Lukacova, Amit Taneja

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Cardiovascular safety of febuxostat versus allopurinol among the Asian patients with or without gout: A systematic review and meta‐analysis by Jian‐hao Deng, Peng‐hui Lai, Li‐shan Xie, Shu‐sheng Qiu, De‐sheng Qiu, Jia‐xing Zhang

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Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end‐stage renal disease by Ryota Tanaka, Yosuke Suzuki, Hiroshi Watanabe, Takashi Fujioka, Kenshiro Hirata, Toshitaka Shin, Tadasuke Ando, Hiroyuki Ono, Ryosuke Tatsuta, Hiromitsu Mimata, Toru Maruyama, Hiroki Itoh

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Differential expression and clinical significance of IGF2BP3 in peritoneal dialysate of patients with varying duration of peritoneal dialysis by Xiaoqi Shao, Ling Yao, Jiao Fu, Mengmeng He, Pei Zhang

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A first‐in‐human phase I study of SHR‐1906, a humanized monoclonal antibody against connective tissue growth factor, in healthy participants by Lin‐Lin Song, Hai‐Yan Zhou, Pan‐Pan Ye, Qian Li, Ke‐Guang Chen, Ye‐Hui Zhang, Fu‐Rong Zhao, Jin‐Yi Shi, Yuan Luo, Min Zhu, Jian‐Jun Zhang, Xin‐Mei Yang, Wei Zhao

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Efficacy of personal pharmacogenomic testing as an educational tool in the pharmacy curriculum: A nonblinded, randomized controlled trial by Chloe Grace, Marti M. Larriva, Heidi E. Steiner, Srujitha Marupuru, Patrick J. Campbell, Hayley Patterson, Cheryl D. Cropp, Dorothy Quinn, Walter Klimecki, David E. Nix, Terri Warholak, Jason H. Karnes

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