Search Results - "translational science"

A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects by Sibel Ucpinar, Borje Darpo, Ann Neale, Philip Nunn, Jin Shu, Katherine A. Chu, Marianne Kavanagh, Hongqi Xue, Pasit Phiasivongsa, Dolca Thomas, Patrick F. Smith

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Lipidomic changes in a novel sepsis outcome‐based analysis reveals potent pro‐inflammatory and pro‐resolving signaling lipids by Dawoud Sulaiman, Dongyuan Wu, Lauren Page Black, Kevin J. Williams, Kiley Graim, Susmita Datta, Srinivasa T. Reddy, Faheem W. Guirgis

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The pharmacokinetics of oral trazpiroben (TAK‐906) after organic anion transporting polypeptide 1B1/1B3 inhibition: A phase I, randomized study by Jatinder K. Mukker, George Dukes, Max Tolkoff, Lisi Wang, Cristina Almansa, Susanna Y. Huh, Mitsuhiro Nishihara, Diane Ramsden, Chunlin Chen

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Dalzanemdor (SAGE‐718), a novel, investigational N‐methyl‐D‐aspartate receptor positive allosteric modulator: Safety, tolerability, and clinical pharmacology in randomized dose‐fin... by Aaron Koenig, Michael Lewis, Jeff Wald, Sigui Li, Mustafa Varoglu, Jing Dai, Abdul Sankoh, Katrina Paumier, James Doherty, Mike Quirk

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Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first‐in‐human phase I study by Andrew Gewitz, Jeanne Mendell, Yuhuan Wang, Charles Harris, Benjamin A. Olenchock, Simona Podgrabinska, Wenjun Zheng, An Zhao, Hao Pan, Frédéric Vanhoutte, John D. Davis

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Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel by Chenling Xiong, Katherina C. Chua, Tore B. Stage, Josefina Priotti, Jeffrey Kim, Anne Altman‐Merino, Daniel Chan, Krishna Saraf, Amanda Canato Ferracini, Faranak Fattahi, Deanna L. Kroetz

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Investigation of CYP3A induction by PF‐05251749 in early clinical development: comparison of linear slope physiologically based pharmacokinetic prediction and biomarker response by Jian Lin, Francois Gaudreault, Nathaniel Johnson, Zhiwu Lin, Parya Nouri, Theunis C. Goosen, Aarti Sawant‐Basak

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Effect of difelikefalin, a selective kappa opioid receptor agonist, on respiratory depression: A randomized, double‐blind, placebo‐controlled trial by Eugene R. Viscusi, Marc C. Torjman, Catherine L. Munera, Joseph W. Stauffer, Beatrice S. Setnik, Sukirti N. Bagal

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Utility of the 13C‐pantoprazole breath test as a CYP2C19 phenotyping probe for children by Keith Feldman, Gregory L. Kearns, Robin E. Pearce, Susan M. Abdel‐Rahman, James Steven Leeder, Alec Friesen, Vincent S. Staggs, Andrea Gaedigk, Jaylene Weigel, Valentina Shakhnovich

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Co‐consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants by John D. Clarke, Sabrina M. Judson, Dan‐Dan Tian, Trevor O. Kirby, Rakshit S. Tanna, Adrienn Matula‐Péntek, Miklós Horváth, Matthew E. Layton, John R. White, Nadja B. Cech, Kenneth E. Thummel, Jeannine S. McCune, Danny D. Shen, Mary F. Paine

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Effect of collateral circulation in patients with multiple craniocervical artery stenoses by Ya Gao, Xuan Liu, Beibei Xu, Ximeng Zhang, Yiqing Wang, Jianqiang Ni, Yi Yang

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CYP2C19 genotypes and osteoporotic fractures in long‐term users of proton pump inhibitors: A hospital‐based study by Yi‐Ju Liao, Yu‐Ting Chen, Tzu‐Hung Hsiao, Ching‐Heng Lin, Ming‐Fen Wu, Chiann‐Yi Hsu, Yi‐Ming Chen, Chun‐Sheng Hsu

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Patient and healthcare professional acceptability of pharmacogenetic screening for DPYD and UGT1A1: A cross sectional survey by Sarah Glewis, Mei Krishnasamy, Senthil Lingaratnam, Sam Harris, Craig Underhill, Chloe Georgiou, Mark Warren, Robert Campbell, Maarten IJzerman, Mussab Fagery, Ian Campbell, Jennifer H. Martin, Jeanne Tie, Marliese Alexander, Michael Michael

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Preclinical assessment of drug-drug interaction of fb‐PMT, a novel anti‐cancer thyrointegrin αvβ3 antagonist by Kazutoshi Fujioka, Mostafa I. Fekry, Jeanne M. Rumsey, Toni Steiner, David Thompson, Shaker A. Mousa

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Association of CYP2C19 genotypes with postoperative atrial fibrillation after coronary artery bypass surgery by Qin Jiang, Keli Huang, Lizhu Han, Hong Kong, Zhenglin Yang, Shengshou Hu

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Drug-drug interactions of icenticaftor (QBW251) with a 5‐probe cytochrome P450 cocktail and oral contraceptives by Felix Huth, Ulrike Glaenzel, Anton Drollmann, Wendy Weis, Julia Zack, Lidiya Bebrevska

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Evobrutinib, a covalent Bruton's tyrosine kinase inhibitor: Mass balance, elimination route, and metabolism in healthy participants by Holger Scheible, Martin Dyroff, Annick Seithel‐Keuth, Eleanor Harrison‐Moench, Nadra Mammasse, Andreas Port, Angelika Bachmann, Jennifer Dong, Jan Jaap vanLier, William Tracewell, David Mitchell

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Formation of CYP3A‐specific metabolites of ibrutinib in vitro is correlated with hepatic CYP3A activity and 4β‐hydroxycholesterol/cholesterol ratio by Jonghwa Lee, John K. Fallon, Philip C. Smith, Klarissa D. Jackson

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Consequences of oral antithrombotic use in patients with chronic kidney disease by Solène M. Laville, Oriane Lambert, Aghiles Hamroun, Marie Metzger, Christian Jacquelinet, Maurice Laville, Luc Frimat, Denis Fouque, Christian Combe, Carole Ayav, Roberto Pecoits‐Filho, Bénédicte Stengel, Ziad A. Massy, Sophie Liabeuf, the CKD‐REIN Study Collaborators

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Manufacturing‐dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development by Neeltje Steeghs, Aaron R. Hansen, Glenn J. Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L. Washburn, Christopher Matheny, Sarina A. Piha‐Paul

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