Search Results - "translational science"

DDGP vs. SMILE in Relapsed/Refractory Extranodal Natural Killer/T‐cell Lymphoma, Nasal Type: A Retrospective Study of 54 Patients by Xin Wang, Junxia Hu, Meng Dong, Mengjie Ding, Linan Zhu, Jingjing Wu, Zhenchang Sun, Xin Li, Lei Zhang, Ling Li, Xinhua Wang, Xiaorui Fu, Guannan Wang, Qingjiang Chen, Mingzhi Zhang, Xudong Zhang

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An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September... by Xiaotong Li, Patrick Ndungu, Sanya B. Taneja, Maryann R. Chapin, Susan B. Egbert, Krishi Akenapalli, Mary F. Paine, Sandra L. Kane‐Gill, Richard D. Boyce

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Intestinal P‐gp activity is reduced in postmenopausal women under breast cancer therapy by Joao Paulo B. Ximenez, Jurandyr Moreira deAndrade, Adriana Rocha, Eduardo Barbosa Coelho, Guilherme Suarez‐Kurtz, Vera Lucia Lanchote

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CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride by Diana María Campodónico, Pablo Zubiaur, Paula Soria‐Chacartegui, Ana Casajús, Gonzalo Villapalos‐García, Marcos Navares‐Gómez, Antía Gómez‐Fernández, Raúl Parra‐Garcés, Gina Mejía‐Abril, Manuel Román, Samuel Martín‐Vílchez, Dolores Ochoa, Francisco Abad‐Santos

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Pharmacokinetics, safety, and tolerability of BMS‐986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment by Hisham Qosa, Claudia H. M. C. deOliveira, Giovanni Cizza, Eric J. Lawitz, Nicholas Colletti, Jeffrey Wetherington, Edgar D. Charles, Giridhar S. Tirucherai

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Multi‐site Investigation of Genetic Determinants of Warfarin Dose Variability in Latinos by Nihal El Rouby, Leiliane Rodrigues Marcatto, Karla Claudio, Letícia Camargo Tavares, Heidi Steiner, Marianna R. Botton, Steve A. Lubitz, Echo N. Fallon, Kevin Yee, Justin Kaye, Stuart A. Scott, Jason Karnes, Paulo Caleb Junior de Lima Santos, Jorge Duconge, Larisa H. Cavallari

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Evaluation of the relationship between polymorphisms in CYP2C19 and the single‐dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study by Shuang Zhou, Ran Xie, Xiaodan Zhang, Xu He, Jie Huang, Yin Jungang, Man Liao, Ying Ding, Dandan Yang, Ying Liu, Qian Zhang, Guoping Yang, Fang Liu, Shengjiang Guan, Qing He, Honggang Lou, Fengyun Gong, Xianmin Meng, Qian Xiang, Xia Zhao, Yimin Cui

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Ischemia‐induced cardiac dysfunction is exacerbated in adiponectin‐knockout mice due to impaired autophagy flux by Hye Kyoung Sung, Jialing Tang, James Won Suk Jahng, Erfei Song, Yee Kwan Chan, Abdul Hadee Lone, Jeffrey Peterson, Ali Abdul‐Sater, Gary Sweeney

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3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration by Hongbing Wang, Paul C. Brown, Edwin C.Y. Chow, Lorna Ewart, Stephen S. Ferguson, Suzanne Fitzpatrick, Benjamin S. Freedman, Grace L. Guo, William Hedrich, Scott Heyward, James Hickman, Nina Isoherranen, Albert P. Li, Qi Liu, Shannon M. Mumenthaler, James Polli, William R. Proctor, Alexandre Ribeiro, Jian‐Ying Wang, Ronald L. Wange, Shiew‐Mei Huang

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First‐in‐human safety, tolerability, and pharmacokinetic results of DFV890, an oral low‐molecular‐weight NLRP3 inhibitor by Ewa Gatlik, Beata Mehes, Emilie Voltz, Ulrike Sommer, Elaine Tritto, Giulia Lestini, Xiaoxi Liu, Parasar Pal, Maria Velinova, Wiliam S. Denney, Yunlin Fu, Anthony Opipari, Dennis Dean, Guido Junge

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Incidental findings in UK healthy volunteers screened for a COVID‐19 vaccine trial by Susanne H. Hodgson, Poppy Iveson, Jessica Larwood, Sophie Roche, Hazel Morrison, Catherine Cosgrove, Eva Galiza, Sabina Ikram, Nana‐Marie Lemm, Savviz Mehdipour, Daniel Owens, Mihaela Pacurar, Michael Schumacher, Robert H. Shaw, Saul N. Faust, Paul T. Heath, Andrew J. Pollard, Katherine R. W. Emary, Katrina M. Pollock, Rajeka Lazarus

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Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function by Kreetta Hämäläinen, Päivi Hirvensalo, Mikko Neuvonen, Aleksi Tornio, Janne T. Backman, Marko Lehtonen, Mikko Niemi

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Females present higher dose‐adjusted drug concentrations of metoprolol and allopurinol/oxypurinol than males by Jessica Hindi, Marc‐Olivier Pilon, Maxime Meloche, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus

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Estimation of glomerular filtration rate for drug dosing in patients with very high or low body mass index by Erik M. Donker, Pierre Bet, Azam Nurmohamed, Erik Serné, George Louis Burchell, Allon N. Friedman, Antoine Bouquegneau, Sandrine Lemoine, Natalie Ebert, Massimo Cirillo, Michiel A. vanAgtmael, Imke H. Bartelink

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Pharmacokinetics, bioavailability, and bioequivalence of lower‐sodium oxybate in healthy participants in two open‐label, randomized, crossover studies by Cuiping Chen, Jack Jenkins, Katie Zomorodi, Roman Skowronski

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Projected Utility of Pharmacogenomic Testing Among Individuals Hospitalized With COVID‐19: A Retrospective Multicenter Study in the United States by James M. Stevenson, G. Caleb Alexander, Natasha Palamuttam, Hemalkumar B. Mehta

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Umbilical cord blood-derived exosomes from healthy term pregnancies protect against hyperoxia‐induced lung injury in mice by Xin‐qi Zhong, Ding Wang, Shuang Chen, Jing Zheng, Tao‐fang Hao, Xiu‐hong Li, Li‐hua Luo, Jian Gu, Chang‐yu Lian, Xiao‐sa Li, Dun‐jin Chen

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Predicting Efavirenz Concentrations in the Brain Tissue of HIV‐Infected Individuals and Exploring their Relationship to Neurocognitive Impairment by Nithya Srinivas, Sarah Beth Joseph, Kevin Robertson, Laura P. Kincer, Prema Menezes, Lourdes Adamson, Amanda P. Schauer, Kimberly H. Blake, Nicole White, Craig Sykes, Paul Luciw, Joseph J. Eron, Alan Forrest, Richard W. Price, Serena Spudich, Ronald Swanstrom, Angela D.M. Kashuba

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First‐in‐human development of a pharmacodynamic biomarker for PAC1 receptor antagonists using intradermal injections of maxadilan by Heleen Marynissen, Linde Buntinx, Dorien Bamps, Marleen Depre, Els Ampe, Anne Van Hecken, Kristin Gabriel, Steve Sands, Gabriel Vargas, Jan de Hoon

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Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH by Mathias B. Møllerhøj, Sanne S. Veidal, Kirstine Tølbøl Thrane, Denise Oró, Agnete Overgaard, Casper Gravesen Salinas, Martin Rønn Madsen, Larissa Pfisterer, Mogens Vyberg, Eric Simon, Andre Broermann, Niels Vrang, Jacob Jelsing, Michael Feigh, Henrik H. Hansen

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