Search Results - "translational science"

A single ascending dose study of single‐stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers by Tsang Tommy Cheung, Andrea On Yan Luk, Yuchen Zhang, Vedran Pavlovic, Cynthia Wat, Sudip Das, Bernadette Surujbally, Miriam Triyatni, Joseph F. Grippo

Connect to this object online.

A first‐in‐human study of KMRC011, a potential treatment for acute radiation syndrome, to explore tolerability, pharmacokinetics, and pharmacodynamics by Eunsol Yang, Hyejung Choi, Jin‐Sol Park, Young‐Woock Noh, Chi‐Min Choi, Woo‐Jong Lee, Jae‐Wook Ko, Jungryul Kim

Connect to this object online.

Optimizing expert and patient input in pediatric trial design: Lessons learned and recommendations from a collaboration between conect4children and European Patient‐CEntric ClinicA... by Britt A. E. Dhaenens, Fenna Mahler, Hannah Batchelor, Pamela Dicks, Segolene Gaillard, Begonya Nafria, Annette Kopp‐Schneider, Maria Alexandra Ribeiro, Matthias Schwab, Monika Sparber‐Sauer, Jonas Leubner, Saskia N. deWildt, Rianne Oostenbrink

Connect to this object online.

A randomized, placebo‐controlled study to evaluate safety and pharmacokinetics of inhaled ribavirin by Peter Couroux, Alexandre Brkovic, Jason L. Vittitow, Robert J. Israel, Chinna Pamidi, Jignesh Patel, Maxime Barakat

Connect to this object online.

Keverprazan, a novel potassium‐competitive acid blocker: Multiple oral doses safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy subjects by Sufeng Zhou, Lijun Xie, Chen Zhou, Lu Wang, Juan Chen, Sijia Ding, Bei Zhu, Mei Su, Feng Shao

Connect to this object online.

Immune response profiling in patients with traumatic injuries associated with alcohol ingestion by Adam W. Breslin, Alexander T. Limkakeng, Elizabeth Silvius, Catherine A. Staton, Chandra Almond, Mary‐Beth Joshi, Bartley Adams, Bria Johnston, Lauren McGowan, Allan D. Kirk, Eric Elster

Connect to this object online.

Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population by Line Skute Bråten, Magnus Ingelman‐Sundberg, Marin M. Jukic, Espen Molden, Marianne Kristiansen Kringen

Connect to this object online.

Model‐informed drug development for immuno‐oncology agonistic anti‐GITR antibody GWN323: Dose selection based on MABEL and biologically active dose by Yan Ji, Deborah Knee, Xinhui Chen, Anhthu Dang, Jennifer Mataraza, Babette Wolf, Sherwin K. B. Sy

Connect to this object online.

Integrating real‐world data and modeling to project changes in femoral neck bone mineral density and fracture risk in premenopausal women by Denise Beck, Insa Winzenborg, Wei Gao, Nael M. Mostafa, Peter Noertersheuser, Stephanie E. Chiuve, Charlotte Owens, Mohamad Shebley

Connect to this object online.

Clinical Evaluation of an Investigational 5 mL Wearable Injector in Healthy Human Subjects by Wendy D. Woodley, Wen Yue, Didier R. Morel, Audrey Lainesse, Ronald J. Pettis, Natasha G. Bolick

Connect to this object online.

Pharmacokinetic and pharmacodynamic drug-drug interactions between evogliptin and empagliflozin or dapagliflozin in healthy male volunteers by Dasohm Kim, Minkyu Choi, Byung Hak Jin, Taegon Hong, Choon Ok Kim, Byung Won Yoo, Min Soo Park

Connect to this object online.

REGN1908‐1909 monoclonal antibodies block Fel d 1 in cat allergic subjects: Translational pharmacokinetics and pharmacodynamics by Mohamed A. Kamal, Robert Dingman, Claire Q. Wang, Ching‐Ha Lai, Manoj Rajadhyaksha, Michelle DeVeaux, Jamie M. Orengo, Allen Radin, John D. Davis

Connect to this object online.

A phase I, randomized, placebo‐controlled study of molnupiravir in healthy Japanese to support special approval in Japan to treat COVID‐19 by Keisuke Nakamura, Katsukuni Fujimoto, Chihiro Hasegawa, Ikuo Aoki, Hiroyuki Yoshitsugu, Hiroyuki Ugai, Naoyoshi Yatsuzuka, Yoshiyuki Tanaka, Kenichi Furihata, Brian M. Maas, Prachi K. Wickremasingha, Kelly E. Duncan, Marian Iwamoto, Selwyn A. Stoch, Naoto Uemura

Connect to this object online.

Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke by Krista R. Schaefer, Jaedon P. Avey, Michael R. Todd, Julie A. Beans, Denise A. Dillard, Laura M. Shireman, Timothy A. Thornton, Rachel F. Tyndale, Kenneth E. Thummel, Renee F. Robinson, Katrina G. Claw

Connect to this object online.

A multi‐purpose Japanese phase I study in the global development of vupanorsen: Randomized, placebo‐controlled, single‐ascending dose study in adults by Kei Fukuhara, Kenichi Furihata, Nobushige Matsuoka, Rio Itamura, Vesper Ramos, Toshiaki Hagi, Hindu Kalluru, Candace Bramson, Steven G. Terra, Jing Liu

Connect to this object online.

Pharmacometabolomics identifies candidate predictor metabolites of an L‐carnitine treatment mortality benefit in septic shock by Michael A. Puskarich, Theodore S. Jennaro, Christopher E. Gillies, Charles R. Evans, Alla Karnovsky, Cora E. McHugh, Thomas L. Flott, Alan E. Jones, Kathleen A. Stringer, for the RACE Investigators

Connect to this object online.

Inflammation altered correlation between CYP2C19 genotype and CYP2C19 activity in patients receiving voriconazole by Sylvia D. Klomp, Anette Veringa, Jan‐Willem C. Alffenaar, Mark G. J. deBoer, Lambert F. R. Span, Henk‐Jan Guchelaar, Jesse J. Swen

Connect to this object online.

Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital by Timothy A. Roberts, Jennifer A. Wagner, Tracy Sandritter, Benjamin T. Black, Andrea Gaedigk, Stephani L. Stancil

Connect to this object online.

Dexamethasone exposure in normal‐weight and obese hospitalized COVID‐19 patients: An observational exploratory trial by Kenza Abouir, Pauline Gosselin, Stéphane Guerrier, Youssef Daali, Jules Desmeules, Olivier Grosgurin, Jean‐Luc Reny, Caroline Samer, Alexandra Calmy, Kuntheavy Roseline Ing Lorenzini

Connect to this object online.

Safety, tolerability, and pharmacokinetics of single‐ and multiple‐dose administration of islatravir (MK‐8591) in adults without HIV by Randolph P. Matthews, Wendy Ankrom, Evan Friedman, Deanne Jackson Rudd, Yang Liu, Robin Mogg, Deborah Panebianco, Inge De Lepeleire, Magdalena Petkova, Jay A. Grobler, Selwyn Aubrey Stoch, Marian Iwamoto

Connect to this object online.