Search Results - "translational science"

The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers by Stefan J. Jodl, Wouter tenVoorde, Stefan Klein, Andrea Wagenfeld, Frank S. Zollmann, Maximilian Feldmüller, Naomi B. Klarenbeek, Digna T. deBruin, Manon A. A. Jansen, Robert Rissmann, Beate Rohde, Matthijs Moerland

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Population pharmacokinetic and exposure‐response analyses of ivosidenib in patients with IDH1‐mutant advanced hematologic malignancies by Xuemin Jiang, Russ Wada, Bill Poland, Huub Jan Kleijn, Bin Fan, Guowen Liu, Hua Liu, Stephanie Kapsalis, Hua Yang, Kha Le

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Clinical significance and underlying mechanism of long non‐coding RNA SNHG12 in lower extremity deep venous thrombosis by Shun Xiao, Chong Wang, Yongxin Li, Kun Zhang, Xuefei Jiao, Zonggang Zhao, Mingjin Guo, Bing Liu

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Tocilizumab as a Therapeutic Agent for Critically Ill Patients Infected with SARS‐CoV‐2 by Russell M. Petrak, Nathan C. Skorodin, Nicholas W. Van Hise, Robert M. Fliegelman, Jonathan Pinsky, Vishal Didwania, Michael Anderson, Melina Diaz, Kairav Shah, Vishnu V. Chundi, David W. Hines, Brian P. Harting, Kamo Sidwha, Brian Yu, Paul Brune, Anjum Owaisi, David Beezhold, Joseph Kent, Dana Vais, Alice Han, Neethi Gowda, Nishi Sahgal, Jan Silverman, Jonathan Stake, Jenie Nepomuceno, Renuka Heddurshetti

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Safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel acetylcholinesterase inhibitor: A phase I study in healthy young and elderly Chinese subjects by Hongjie Qian, Chengyin Yu, Huijuan Zhu, Qichen Ding, Yuting Cai, Jiao Jing, Xin Xu, Runcong Guo, Haiyan Zhang, Hong Liu, Xiaoyan Chen, Yun Liu

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Effects of genotype and food on naltrexone exposure in adolescents by Stephani L. Stancil, Michaela Voss, Whitney Nolte, John Tumberger, William Adelman, Susan Abdel‐Rahman

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Risk of cognitive impairment in men with advanced prostate cancer treated with NHAs: A systematic review and network meta‐analysis by Shi‐Wei Huang, Li‐Chin Chen, Chi‐Shin Tseng, Chung‐Hsin Chen, Lun‐Hsiang Yuan, Wen‐Yi Shau, Yeong‐Shiau Pu

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Comparing five equations to estimate glomerular filtration rate or creatinine clearance and assign individuals to KDIGO categories across the full age spectrum using real world dat... by Simon Dagenais, Zaher Radi, Janelle Burnham, Smita Goodman, Griffith Bell, Brian Corrigan, Shelby Corman, Gary Friedman

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Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics by Bianca Vora, Deanna J. Brackman, Ling Zou, Maria Garcia‐Cremades, Marina Sirota, Radojka M. Savic, Kathleen M. Giacomini

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Pharmacokinetics, safety, and tolerability of gepotidacin administered as single or repeat ascending doses, in healthy adults and elderly subjects by Courtney Tiffany, Etienne F. Dumont, Mohammad Hossain, Meenakshi Srinivasan, Brandon Swift

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Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor by Sonomi Maruyama, Hester Visser, Takashi Ito, Tharin Limsakun, Hamim Zahir, Daniel Ford, Ben Tao, Cynthia A. Zamora, Jeffrey G. Stark, Hubert S. Chou

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Associations between uncertainties identified by the European Medicines Agency and national decision making on reimbursement by HTA agencies by Lourens T. Bloem, Rick A. Vreman, Niels W. L. Peeters, Jarno Hoekman, Menno E. van derElst, Hubert G. M. Leufkens, Olaf H. Klungel, Wim G. Goettsch, Aukje K. Mantel‐Teeuwisse

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Toward pharmacogenetic SLCO1B1‐guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model by Zachary L. Taylor, Lauren E. Thompson, Heather Bear, Tomoyuki Mizuno, Alexander A. Vinks, Laura B. Ramsey

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The Learning Health System Competency Appraisal Inventory (LHS‐CAI): A novel tool for assessing LHS‐focused education needs by Alexandra J. Greenberg‐Worisek, Nathan D. Shippee, Cory Schaffhausen, Kelli Johnson, Nilay D. Shah, Mark Linzer, Timothy Beebe, Felicity Enders

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Pharmacokinetics of Anakinra in Subjects of Heavier vs. Lighter Body Weights by Bing‐Bing Yang, Peter Gozzi, John T. Sullivan

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Concentration‐QTcF analysis of quizartinib in patients with newly diagnosed FLT3‐internal‐tandem‐duplication‐positive acute myeloid leukemia by Pavan Vaddady, Giovanni Smania, Shintaro Nakayama, Hiroyuki Inoue, Abhinav Kurumaddali, Malaz Abutarif, Ming Zheng

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Pharmacokinetics, safety, and tolerability of inhaled remdesivir in healthy participants by Rita Humeniuk, Kavita Juneja, Shuguang Chen, Scott Ellis, Olena Anoshchenko, Deqing Xiao, Aaron Share, Matthew Johnston, Santosh Davies, Adam DeZure, Joe Llewellyn, Anu Osinusi, Helen Winter, Sandhya Girish, Ramesh Palaparthy, Mark Dresser

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Association between serum albumin to serum creatinine ratio and mortality risk in patients with heart failure by Shiyang Li, Xiaoshuang Xie, Xiaobin Zeng, Shihai Wang, Jianjun Lan

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Safety, Tolerability, and Pharmacokinetics of the Mineralocorticoid Receptor Modulator AZD9977 in Healthy Men: A Phase I Multiple Ascending Dose Study by Andrew Whittaker, Åsa M. Kragh, Judith Hartleib‐Geschwindner, Muna Albayaty, Anna Backlund, Peter J. Greasley, Maria Heijer, Magnus Kjaer, Pablo Forte, Robert Unwin, Linda Wernevik, Hans Ericsson

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Effects of Rovalpituzumab Tesirine on Ventricular Repolarization in Patients With Small‐Cell Lung Cancer by Jonathan W. Goldman, Minal Barve, Jyoti D. Patel, Antoinette Wozniak, Afshin Dowlati, Alexander Starodub, Taofeek K. Owonikoko, William Edenfield, Scott A. Laurie, Daniel Da Costa, Satwant Lally, Martina Koch, Matthew P. Kosloski, David Hoffman, Grace K. Dy

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